Results 61 to 70 of about 4,310,301 (302)

Statistical methods for Mendelian randomization in genome-wide association studies: A review

Computational and Structural Biotechnology Journal, 2022
Genome-wide association studies have yielded thousands of associations for many common diseases and disease-related complex traits. The identified associations made it possible to identify the causal risk factors underlying diseases and investigate the ...
Frederick J. Boehm, Xiang Zhou
doaj  

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants

BMC Medicine, 2022
Background Despite early interest in the health effects of polyunsaturated fatty acids (PUFA), there is still substantial controversy and uncertainty on the evidence linking PUFA to cardiovascular diseases (CVDs).
Maria Carolina Borges, Philip C. Haycock, Jie Zheng, Gibran Hemani, Michael V. Holmes, George Davey Smith, Aroon D. Hingorani, Deborah A. Lawlor   +7 more
doaj   +1 more source

Systemic inflammatory regulators and proliferative diabetic retinopathy: A bidirectional Mendelian randomization study

Frontiers in Immunology, 2023
Background Increasing evidence shows that systemic inflammation is an embedded mechanism of proliferative diabetic retinopathy (PDR). However, the specific systemic inflammatory factors involved in this process remained obscure.
Qiqin Shi, Qiangsheng Wang, Zhenqiang Wang, Jiawen Lu, Ruobing Wang   +4 more
semanticscholar   +1 more source

The next 10 years of behavioural genomic research

JCPP Advances, Volume 2, Issue 4, December 2022., 2022
Three transformative developments for behavioural genomic research in the next 10 years are described. First, behavioural genomic research will use dimensional measures to reveal the hierarchical genetic architecture of psychopathology. A second direction for behavioural genomic research will be to investigate causa models of GE interplay.
Robert Plomin
wiley   +1 more source

The causal relationship between obesity and IgA nephropathy: a Mendelian randomization study

Linchuang shenzangbing zazhi
ObjectiveTo explore the potential causal relationship between obesity and IgA nephropathy through Mendelian randomization. MethodsSummary-level data from genome-wide association studies of obesity-related shapes (body mass index, percentage body fat ...
Peng-tao Dong, Zheng Wang, Xiao-yu Li, Qing Zhang   +3 more
doaj   +1 more source

Causal effects of gut microbiome on hypertension: a Mendelian randomization study

Frontiers in Microbiology, 2023
BackgroundPrevious observational studies have shown that there is an important relationship between gut microbiota and hypertension, we performed a two-sample Mendelian randomization analysis to examine whether the gut microbiota is causally related to ...
Gang He, Yu Cao, Houzhao Wang, Houzhao Wang, Xiaoying Lv   +4 more
doaj   +1 more source

Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study

Alimentary Pharmacology and Therapeutics, 2023
Evidence for antioxidants, minerals and vitamins in relation to the risk of Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent.
Jie Chen, Xixian Ruan, S. Yuan, Minzi Deng, Han Zhang, Jing Sun, Lili Yu, J. Satsangi, S. Larsson, Evropi Therdoratou, Xiao-Yang Wang, Xia Li   +11 more
semanticscholar   +1 more source

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

MendelianRandomization v0.9.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 2; peer review: 2 approved]

Wellcome Open Research, 2023
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data.
Stephen Burgess, Ting Ye, Ashish Patel, Zhaotong Lin, Amy M. Mason, Haoran Xue, Benjamin Woolf, Siqi Xu   +7 more
doaj  

Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study

Journal of Neuroinflammation
Background Some studies have shown that gut microbiota may be associated with dementia. However, the causal effects between gut microbiota and different types of dementia and whether cytokines act as a mediator remain unclear.
Dong-Wei Ji, Wen-Zhu Chen, Lei Zhang, Zhi-Hua Zhang, Lijian Chen   +4 more
semanticscholar   +1 more source