Results 61 to 70 of about 4,362,965 (333)

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Biomarkers and type 2 diabetes [PDF]

, 2015
This is the author accepted manuscript. The final version is available from Bioscientifica via http://dx.doi.org/10.1530/EC-15-0087Many biomarkers are associated with type 2 diabetes (T2D) risk in epidemiological observations.
Abbasi, Ali
core   +4 more sources

Association between frailty and depression: A bidirectional Mendelian randomization study

Science Advances, 2023
Frailty and depression were linked in observational studies, but the causality remains ambiguous. We intended to explore it using Mendelian randomization (MR). We obtained frailty genome-wide association study (GWAS) data from UK Biobank and TwinGen meta-
Mingzhao Deng, Fang Liu, Yuehui Liang, Kai Wang, J.-Q. Nie, Jiewei Liu   +5 more
semanticscholar   +1 more source

Causal relationship among obesity and body fat distribution and epilepsy subtypes

Frontiers in Neurology, 2022
ObjectiveThe observational studies indicate an association between obesity and epilepsy, but it is unclear whether such an association responds to causality.
Kaiping Zhou, Huan Yang, Ruomeng Chen, Weiping Wang, Zhenzhen Qu   +4 more
doaj   +1 more source

No Evidence of a Genetic Causal Relationship between Ankylosing Spondylitis and Gut Microbiota: A Two-Sample Mendelian Randomization Study

Nutrients, 2023
Objective: Ankylosing spondylitis (AS) is associated with a variety of gut microbiotas. We aim to analyze the causal relationship between the two at the genetic level.
Ming-juan Yang, Xianjie Wan, Haishi Zheng, Ke Xu, Jiale Xie, Hui Yu, Jiachen Wang, P. Xu   +7 more
semanticscholar   +1 more source

Mendelian randomization and pleiotropy analysis

Quantitative Biology, 2021
BackgroundMendelian randomization (MR) analysis has become popular in inferring and estimating the causality of an exposure on an outcome due to the success of genome wide association studies. Many statistical approaches have been developed and each of these methods require specific assumptions.ResultsIn this article, we review the pros and cons of ...
openaire   +4 more sources

Guidelines for performing Mendelian randomization investigations [PDF]

Wellcome Open Research, 2019
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts.
Caroline L Relton, Michael V. Holmes, Michael V. Holmes, George Davey Smith, Evropi Theodoratou, Evropi Theodoratou, M. Maria Glymour, Cosetta Minelli, Fernando Pires Hartwig, Fernando Pires Hartwig, Frank Dudbridge, Neil M Davies, Dipender Gill, Stephen Burgess   +13 more
openaire   +2 more sources

Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study

Frontiers in Public Health
BackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We
Runmin Cao, Honghe Jiang, Yurun Zhang, Ying Guo, Weibin Zhang   +4 more
doaj   +1 more source

Instrumental Variables Estimation with Some Invalid Instruments and its Application to Mendelian Randomization

, 2014
Instrumental variables have been widely used for estimating the causal effect between exposure and outcome. Conventional estimation methods require complete knowledge about all the instruments' validity; a valid instrument must not have a direct effect ...
Cai, T. Tony, Kang, Hyunseung, Small, Dylan S., Zhang, Anru   +3 more
core   +2 more sources

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure

Nature Communications, 2023
We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1 million control individuals of European ancestry to uncover novel genetic determinants for heart ...
Danielle Rasooly, G. Peloso, A. Pereira, Hesam Dashti, C. Giambartolomei, E. Wheeler, N. Aung, B. Ferolito, Maik Pietzner, E. Farber-Eger, Q. Wells, Nicole M. Kosik, Liam Gaziano, D. Posner, A. P. Bento, Q. Hui, Chang Liu, Krishna G. Aragam, Zeyuan Wang, Brian R. Charest, J. Huffman, P. Wilson, Lawrence S. Phillips, J. Whittaker, P. Munroe, Steffen E. Petersen, Kelly Cho, Andrew R. Leach, M. P. Magariños, J. Gaziano, C. Langenberg, Yan V. Sun, J. Joseph, J. Casas   +33 more
semanticscholar   +1 more source