Results 111 to 120 of about 1,141,533 (358)

Mendelian randomization studies of risk and protective factors for osteoporosis: a systematic review and meta-analysis

Frontiers in Endocrinology
BackgroundMendelian randomization is believed to attenuate the biases inherent in observational studies, yet a meta-analysis of Mendelian randomization studies in osteoporosis has not been conducted thus far.
Wenhao Ji, Wenhao Ji, Bin Pan, Bin Pan, Xin Chen, Xin Chen, Zhaobai Lao, Zhaobai Lao, Wanlei Yang, Wanlei Yang, Yu Qian, Yu Qian   +11 more
doaj   +1 more source

Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis

JAMA cardiology, 2018
Importance Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized trials of several therapies that reduce Lp(a) levels by 25% to 35% have not provided ...
S. Burgess, B. Ference, James R. Staley, F. Daniel, Freitag, A. Mason, S. F. Nielsen, P. Willeit, Robin, Young, P. Surendran, Savita Karthikeyan, Thomas R. Bolton, J. Peters, P. Kamstrup, A. Tybjærg‐Hansen, M. Benn, A. Langsted, P. Schnohr, Signe, Vedel-Krogh, C. Kobylecki, I. Ford, C. Packard, S. Trompet, J. Jukema, N. Sattar, Emanuele Di, Angelantonio, D. Saleheen, J. Howson, G. Borge, Nordestgaard, A. Butterworth, J. Danesh   +34 more
semanticscholar   +1 more source

Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations

Diabetes Care, 2020
OBJECTIVE Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes ...
Ju-Sheng Zheng, J. Luan, E. Sofianopoulou, F. Imamura, I. Stewart, F. Day, Maik Pietzner, E. Wheeler, L. Lotta, T. Gundersen, P. Amiano, E. Ardanaz, M. Chirlaque, G. Fagherazzi, P. Franks, R. Kaaks, N. Laouali, F. Mancini, P. Nilsson, N. Onland-Moret, A. Olsen, K. Overvad, S. Panico, D. Palli, F. Ricceri, O. Rolandsson, A. Spijkerman, M. Sánchez, M. Schulze, N. Sala, S. Sieri, A. Tjønneland, A. Tjønneland, R. Tumino, Y. T. V. D. Schouw, E. Weiderpass, E. Riboli, J. Danesh, A. Butterworth, S. Sharp, C. Langenberg, N. Forouhi, N. Wareham   +42 more
semanticscholar   +1 more source

Genetic causal association between heart failure, frailty and poisoning by narcotics and psychodysleptics: A two‐sample Mendelian randomization

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Observational studies have suggested associations between heart failure (HF), frailty and poisoning by narcotics and psychodysleptics (PNP). However, establishing causal relationships has been challenging. This study used a two‐sample Mendelian randomization (MR) approach to investigate the genetically proxied causality between HF ...
Bing Wang, Hong Yu, Meng Cai, Xianqiao Xie   +3 more
wiley   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis

Brain and Behavior
AbstractObjectiveEpidemiological studies revealed an unestablished association between neuroticism and posttraumatic stress disorder (PTSD) and we conducted mendelian randomization (MR) analyses to examine whether neuroticism clusters of worry, depressed affect, and sensitivity to environmental stress and adversity (SESA) were involved in the ...
Zifan You, Shanshan Chen, Jinsong Tang
openaire   +3 more sources

Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study

Heliyon
This study aimed to investigate whether there is a causal relationship between educational attainment and delirium at the genetic level using the Mendelian randomization method, and provide new evidence for studies in this field.
Xianjie Wan, Hui Yu, Mingyi Yang, Weikun Hou, Jiale Xie, Ke Xu, Yujie Ma, Rui Ma, Fan Wang, Peng Xu   +9 more
doaj  

Loss of the epithelial transcription factor grhl3 leads to variably penetrant developmental phenotypes in zebrafish

Developmental Dynamics, EarlyView.
Abstract Background Environmental influence is critical for embryogenesis but is significantly under‐appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on the developmental phenotype of zebrafish lacking the transcription factor Grainyhead‐like 3 (grhl3 ...
Nishanthi Mathiyalagan, Travis K. Johnson, Zachary Di Pastena, Jarrad N. Fuller, Lee B. Miles, Sebastian Dworkin   +5 more
wiley   +1 more source

Can Omega-3 prevent the accidence of stroke: a mendelian randomization study

Hereditas
Background The lipid-lowering effects of Omega-3 fatty acids have been widely reported, yet their impact on ischemic stroke remains controversial. Reports on the protective effects of unsaturated fatty acids, such as Omega-6 and Omega-7, as well as ...
Chongcheng Xi, Jie Zhang, Haihui Liu, Sian Tao, Ying Xie, Jibin Liu, Changqing Tong, Dong Tian, Hua Ye, Xiaobo Zhang   +9 more
doaj   +1 more source

Genetically predicted ankylosing spondylitis increases the risk of heart failure: a Mendelian randomization study

Frontiers in Cardiovascular Medicine
BackgroundObservational studies have indicated a potential association between ankylosing spondylitis and elevated cardiovascular disease (CVD) risk. However, it remains uncertain whether this association reflects a causal association.
Chennan Liu, Chennan Liu, Laicheng Wang, Mei Lin, Mei Lin, Jing You, Jing You, Xuan Zheng, Xuan Zheng, Ailing Wang, Ailing Wang, Yunchai Lin, Yunchai Lin, Feng Peng, Feng Peng, Dan Hu   +15 more
doaj   +1 more source