Results 141 to 150 of about 1,141,533 (358)

Deciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from Genetics Analysis and Machine Learning

Exploration, EarlyView.
The causal relationship between gut microbiota and brain tumors and potential prognostic value of microbiota are still unclear. This study confirmed the causal effects of specific gut microbiota on three common brain tumors and identified microbe‐related genes that are expressed in brain tissue and correlated with the abundance of gut microbiota ...
Changwu Wu, Fushu Luo, Yongye Zhu, Chunbo Liu, Zheng Chen, Xiangyu Wang, Jun Tan, Qing Liu   +7 more
wiley   +1 more source

Exploration of the causal relationship and mechanisms between serum albumin and venous thrombosis: a bidirectional mendelian randomization analysis and bioinformatics study

Thrombosis Journal
Background To explore the causal relationship between serum albumin and venous thromboembolism (VTE) comprises deep vein thrombosis (DVT) and its consequential condition, pulmonary embolism (PE), through Mendelian randomization (MR) design, seeking to ...
Xuemei Xia, Xin Tie, Maolin Hong, Wanhong Yin   +3 more
doaj   +1 more source

The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: a Mendelian randomization meta-analysis [PDF]

, 2014
Georgios K. Nikolopoulos, Pantelis G. Bagos, Iraklis Tsangaris, Chrissa Tsiara, Petros Kopterides, George Vaiopoulos, Violetta Kapsimali, Stefanos Bonovas, Argirios Ε. Tsantes   +8 more
openalex   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Juvenile idiopathic arthritis and primary ovarian failure: a two-sample Mendelian randomization analysis in a mixed-gender cohort

Frontiers in Endocrinology
BackgroundThe causal relationship between juvenile idiopathic arthritis (JIA) and primary ovarian failure (POF) remains uncertain. To elucidate this relationship, we employed a two-sample Mendelian randomization analysis.MethodsThe single nucleotide ...
Yuanhang Mo, Anquan Shang, Guoguo Wei, Donghui Xu, Yuxi Hou, Xiaowen Shao, Chaoyan Yue   +6 more
doaj   +1 more source

Fetuin-A and risk of coronary heart disease: A Mendelian randomization analysis and a pooled analysis of AHSG genetic variants in 7 prospective studies [PDF]

, 2015
Lars Erik Laugsand, Joachim H. Ix, Traci M. Bartz, Luc Djoussé, Jorge R. Kizer, Russell P. Tracy, Abbas Dehghan, Kathryn M. Rexrode, Oscar L. López, Eric B. Rimm, David S. Siscovick, Christopher J. O’Donnell, Anne B. Newman, Kenneth J. Mukamal, Majken K. Jensen   +14 more
openalex   +1 more source

Therapeutic targets for muscle weakness in older adults: proteome-wide Mendelian randomization and colocalization analyses

The Journal of Nutrition, Health and Aging
Background: Recent research highlights the importance of muscular strength as a key factor in physical fitness, a strong indicator of overall mortality risk, and a vital target for preventing chronic diseases.
Shuai-Kang Wang, Qi-Jun Wang, Xuan Zhao, Peng Wang, Xiang-Yu Li, Wei Wang, Shi-Bao Lu   +6 more
doaj  

Gut microbiota influences colorectal cancer through immune cell interactions: a Mendelian randomization study

Discover Oncology
Background Colorectal cancer (CRC) is the most prevalent malignant tumor of the digestive system globally, posing a significant threat to human health and quality of life.
Linyi Zheng, Yuqiang Li, Cenap Güngör, Heming Ge   +3 more
doaj   +1 more source

Causal relevance of circulating high-density lipoprotein cholesterol with cancer: a Mendelian randomization meta-analysis [PDF]

, 2015
Chunhua Yang, Geng Tian, Jia Mi, Xiaodan Wei, Xuri Li, Xianglin Li, Wenming Wang, Bin Wang   +7 more
openalex   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source