Results 141 to 150 of about 72,268 (331)

Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization

Brain and Behavior
Background Given inconsistent evidence regarding the migraine‐Alzheimer's disease association, this Mendelian randomization (MR) study examines their potential causal relationship. Methods GWAS summary statistics for migraine and Alzheimer's disease were
Ran Bi, Weimin Zhao, Jiaoxuan Li, Songji Han, Haotian Qi, Jian Liu, Jinpu Wu, Shengxian Xu, Zhongda Sun, Zhenru Liu   +9 more
doaj   +1 more source

Hypothyroidism correlates with osteoporosis: potential involvement of lipid mediators

Frontiers in Medicine
BackgroundObservational studies have demonstrated a correlation between thyroid dysfunction and osteoporosis (OP); however, the underlying causality has yet to be fully elucidated.MethodsThe necessary dataset was sourced from public databases. Initially,
Pengyuan Leng, Ying Qiu, Mengxue Zhou, Yuhang Zhu, Na Yin, Mingming Zhou, Weili Wu, Min Liu   +7 more
doaj   +1 more source

Periodontitis and osteoporosis: a two-sample Mendelian randomization analysis

Brazilian Journal of Medical and Biological Research
The incidences of periodontitis and osteoporosis are rising worldwide. Observational studies have shown that periodontitis is associated with increased risk of osteoporosis. We performed a Mendelian randomization (MR) study to genetically investigate the causality of periodontitis on osteoporosis.
Jiale Wu, Lihui Yao, Yuchen Liu, ShuaiShuai Zhang, Kan Wang   +4 more
openaire   +3 more sources

Exploring the Link Between Psoriasis and Genetic Predictors of Cardiac Magnetic Resonance Traits: A Bidirectional Mendelian Randomization Study

iNew Medicine, EarlyView.
ABSTRACT Psoriasis is a chronic autoimmune disease characterized by systemic inflammation and skin involvement, affecting millions of individuals worldwide. However, few studies have evaluated whether psoriasis and cardiac magnetic resonance imaging (CMR) traits share a common genetic basis.
Junlin Yang, Pengzhan Yin, Shutian An, Zhanglei Li, Yewen Jiang, Jun Wang, Yongqiang Yu, Ren Zhao, Xiaohu Li   +8 more
wiley   +1 more source

Child height, health and human capital: evidence using genetic markers [PDF]

Height has long been recognised as associated with better outcomes: the question is whether this association is causal. We use children’s genetic variants as instrumental variables (IV) to deal with possible unobserved confounders and examine the effect ...
Carol Propper, Debbie A. Lawlor, Frank Windmeijer, George Davey Smith, Stephanie von Hinke Kessler Scholder   +4 more
core  

Socioeconomic Status Modifies the Risk of Gastric Cancer Through Metabolomic Signature: Evidence From a Prospective Cohort Study

iNew Medicine, EarlyView.
ABSTRACT The role of metabolites in the association between socioeconomic status (SES) and gastric cancer remains unclear. This study seeks to elucidate the role of metabolomics in the association between SES and gastric cancer, as well as to explore potential interactions between metabolic signatures and polygenic risk score (PRS) in the context of ...
Shiyin Meng, Shangxin Zhang, Jing Wang, Zhuoyi Wu, Wenjie Xuan, Jiawei Zhang, Qihong Zhao, Anla Hu, Jing Ni   +8 more
wiley   +1 more source

Exploration of the causal relationship and mechanisms between serum albumin and venous thrombosis: a bidirectional mendelian randomization analysis and bioinformatics study

Thrombosis Journal
Background To explore the causal relationship between serum albumin and venous thromboembolism (VTE) comprises deep vein thrombosis (DVT) and its consequential condition, pulmonary embolism (PE), through Mendelian randomization (MR) design, seeking to ...
Xuemei Xia, Xin Tie, Maolin Hong, Wanhong Yin   +3 more
doaj   +1 more source

Leukemia and risk of stroke: a Mendelian randomization analysis

BMC Neurology
Observational studies suggest an association between leukemia and stroke, but causality remains unclear. Certain leukemia types may increase stroke risk, but variations exist in stroke and mortality rates across leukemia subtypes. This study employed Mendelian randomization (MR) to investigate links between leukemia subtypes and stroke.We conducted a ...
Xiaoyao Yi, Jingrui Zhu, Xiang Zhang, Ning Huang, Yuan Cheng   +4 more
openaire   +3 more sources

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

Causal association of plasminogen activators and their inhibitors with Alzheimer’s disease: a Mendelian randomization study

Archives of Medical Science
Introduction Alzheimer’s disease (AD) is the most common cause of dementia and contributes to a huge burden of disease worldwide. Observational studies have found that tissue plasminogen activator (t-PA) inhibits the development of AD, but little is ...
Xin Guo, Fangyu Gao, Baolong Pan, Feng Gao, Jingsi Zhang, Shanshan Wang, Qiao Niu   +6 more
doaj   +1 more source