Results 151 to 160 of about 1,141,533 (358)

Mendelian randomization analysis of female reproductive factors on osteoarthritis

Medicine
Epidemiology shows women have a higher incidence of osteoarthritis (OA) than men. However, there is not enough evidence to suggest a direct correlation between female reproductive factors and OA. Therefore, this study will employ Mendelian randomization (MR) analysis to investigate whether there is a causal relationship between the 2. This study used a
Pang, Liang, Wu, Kai, Su, Pingping, Liao, Zhicheng, Lv, Cunxian   +4 more
openaire   +2 more sources

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Thyroid Function and Risk of Anemia: A Multivariable-Adjusted and Mendelian Randomization Analysis in the UK Biobank [PDF]

, 2021
Nicolien A van Vliet, Annelies E.P. Kamphuis, Wendy P. J. den Elzen, Gerard J. Blauw, Jacobijn Gussekloo, Raymond Noordam, Diana van Heemst   +6 more
openalex   +3 more sources

Evaluation of the Association Between Postpartum Hemorrhage and Antidepressant Use: A Mendelian Randomization Study

Drugs - Real World Outcomes
Background The relationship between antidepressants, depression, and the incidence of postpartum hemorrhage (PPH) has been reported in observational studies, but the causal link between these factors remains unknown.
Zhenzhen Chen, Qingqing Lv, Shiteng Lin, Wanlong Lin, Wei Zhuang   +4 more
doaj   +1 more source

Commentary: Mendelian randomization analysis identifies circulating vitamin D as a causal risk factor for ovarian cancer [PDF]

, 2016
Caroline J. Bull, James Yarmolinsky, Kaitlin H. Wade   +2 more
openalex   +1 more source

Lipid metabolism and inflammation as key drivers in preterm birth: A comprehensive analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the alterations in lipid metabolites and circulating inflammatory factors associated with preterm birth, elucidate their interactions, and uncover the underlying pathophysiologic mechanisms. By identifying potential predictive biomarkers and informing the development of effective therapeutic interventions, this ...
Shu Xiao, ChaoChao Wei
wiley   +1 more source

Inflammation and keratoconus: A comprehensive bidirectional Mendelian randomization analysis

Medicine
An increasing body of evidence supports the involvement of inflammation and immune responses in the occurrence and development of keratoconus (KC). However, the causal relationship between inflammatory factors and KC remains unclear. We employed a 2-way Mendelian randomization (MR) approach to investigate the interaction between KC and inflammatory ...
Zhang, Xueyan, Cui, Fenghua, Wang, Qiaoling, Zhang, Chenming   +3 more
openaire   +2 more sources

Editorial: Mendelian Randomization Analysis Identifies Body Mass Index and Fasting Insulin as Potential Causal Risk Factors for Pancreatic Cancer Risk [PDF]

, 2017
Konstantinos K. Tsilidis, James Y. Dai, Ulrike Peters   +2 more
openalex   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Unveiling new protein biomarkers and therapeutic targets for acne through integrated analysis of human plasma proteomics and genomics

Frontiers in Immunology
BackgroundThe current landscape of acne therapeutics is notably lacking in targeted treatments, highlighting a critical need for the discovery of new drug targets to improve treatment outcomes.ObjectivesThis study aims to investigate the connections ...
Sui Deng, Rui Mao, Yifeng He
doaj   +1 more source