Results 181 to 190 of about 72,268 (331)

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

General and central obesities were associated with increased risk of inflammatory bowel disease: A large‐scale prospective cohort study

VIEW, EarlyView.
Prior evidence suggested inconsistent findings in terms of the relationship between obesity and inflammatory bowel disease (IBD) occurrence. We demonstrated that both general and central obesities were associated with an increased risk of developing IBD, ulcerative colitis, and Crohn's disease in a large‐scale prospective cohort.
Qian Zhang, Yijun Chen, Shuang Yu, Si Liu, Shutian Zhang, Shanshan Wu   +5 more
wiley   +1 more source

Mass spectrometry‐based mitochondrial proteomics for cancer biomarker discovery

VIEW, EarlyView.
Figure.1 Schematic diagram of MS‐based mitochondrial proteomics for cancer biomarker discovery. The workflow highlights the integration of advanced technological platforms in mitochondrial proteomics and their application in cancer biomarker discovery.
Zheng Cao, ZiKun Song, Weijie Zhou, Xiaohui Liu, Yanling Liu, Peng R. Chen, Kun Qian   +6 more
wiley   +1 more source

A Mendelian randomization analysis of the relationship between cardioembolic risk factors and ischemic stroke [PDF]

, 2021
Danyang Tian, Linjing Zhang, Zhenhuang Zhuang, Tao Huang, Dongsheng Fan   +4 more
openalex   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

The Impact of Omega-3 Fatty Acids on SM23-33 Abundance in Stool and Children with Obesity: A Mendelian Randomization Analysis [PDF]

Min Zhang
openalex   +1 more source

Sex Hormones and the Risk of Nasal Polyps: A Two‐Sample Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The pathophysiological roles of sex hormones in airway inflammation have drawn much attention recently. We aimed to explore the causal effect of sex hormones on chronic rhinosinusitis (CRS) and nasal polyps (NP) via a Mendelian randomization (MR) study.
Ying Zhu, Jia‐Yao Zhou, Shi‐Yao Zhang, Ru Tang, Chun‐Yu Luo, Yue‐Long Gu, Zhi‐Peng Li, Wei‐Tian Zhang   +7 more
wiley   +1 more source

Chinese Guidelines for the Diagnosis and Surgical Treatment of Adult Obstructive Sleep Apnea (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea (OSA) is a common chronic disorder characterized by abnormal breathing during sleeping. OSA can damage various organs throughout the body and is burdensome, both socially and economically. Moreover, as OSA has been increasingly studied in recent years, new evidence‐based guidelines for its diagnosis and surgical ...
Working Group of Guideline for the Diagnosis and Surgical Treatment of Adult OSA, Subspecialty Group of Laryngopharyngology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association, Subspecialty Group of Voice, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery   +7 more
wiley   +1 more source

Genetic engineering for SIT application: a fruit fly‐focused review

Insect Science, EarlyView.
Abstract Sterile insect technique (SIT) has become a key component of efficient pest control. Fruit fly pests from the Drosophilidae and Tephritidae families pose a substantial and overwhelmingly increasing threat to the agricultural industry, aggravated by climate change and globalization among other contributors.
Serafima Davydova, Danheng Yu, Angela Meccariello   +2 more
wiley   +1 more source

Association between Serum 25-Hydroxyvitamin D Levels and Skin Cancer Risk: An Observational Study Based on NHANES and Mendelian Randomization Analysis [PDF]

Jianhua Meng, Ruofei Du, P. P. Li, Jun Lyu   +3 more
openalex   +1 more source