Results 11 to 20 of about 72,268 (331)

Blood lipids and prostate cancer: a Mendelian randomization analysis [PDF]

Cancer Medicine, 2016
Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22
Amin Al Olama, A, Batra, J, Benlloch, S, Blot, WJ, Bonilla, C, Brenner, H, Bull, CJ, Cannon-Albright, L, Cybulski, C, Davies, N, Easton, D, Eeles, R, Giles, GG, Gronberg, H, Haiman, CA, Haycock, P, Holly, JM, Kaneva, R, Khaw, KT, Kibel, AS, Kote-Jarai, Z, Lewis, SJ, MacInnis, RJ, Maier, C, Martin, RM, Micheal, A, Muir, K, Neal, D, Nordestgaard, BG, Pandha, H, Park, J, Pashayan, N, Perks, CM, PRACTICAL consortium,, Richards, JB, Schleutker, J, Smith, GD, Stanford, JL, Teixeira, MR, Thibodeau, S, Travis, RC, Wiklund, F, Yu, OH   +42 more
core   +11 more sources

Dietary intake and periodontal health: Evidence from a Mendelian randomization analysis [PDF]

Journal of International Medical Research
Objective This study aimed to systematically examine the causal relationships between 19 common dietary factors and the risk of periodontal disease, thereby providing reliable evidence for targeted nutritional interventions.
Fulin Yan, Yongji Feng, Xin Dai, Hui Li
doaj   +2 more sources

Selenium and cancer risk: Wide‐angled Mendelian randomization analysis [PDF]

International Journal of Cancer, 2021
AbstractEvidence on the association between selenium and cancer risk is inconclusive. We conducted a Mendelian randomization study to examine the associations of selenium levels with 22 site‐specific cancers and any cancer. Single nucleotide polymorphisms (SNPs) strongly associated with toenail and blood (TAB) and blood selenium levels in mild linkage ...
Yuan, Shuai, Mason, Amy, Carter, Paul, Vithayathil, Mathew, Kar, Siddhartha, Burgess, Stephen, Larsson, Susanna C   +6 more
openaire   +5 more sources

COVID-19 is associated with the risk of cardiovascular disease death: A two-sample Mendelian randomization study

Frontiers in Cardiovascular Medicine, 2022
ObjectiveThis study aimed to estimate the causal effects of Coronavirus disease 2019 susceptibility and hospitalization on cardiovascular disease death using two-sample Mendelian randomization analysis.MethodsWe used statistics from a genome-wide ...
Jia-peng Miao, Xiao-yu Gu, Rui-zheng Shi
doaj   +1 more source

ACLY and CKD: A Mendelian Randomization Analysis

Kidney International Reports, 2022
Adenosine triphosphate-citrate lyase (ACLY) inhibition is a therapeutic strategy under investigation for atherosclerotic cardiovascular disease, nonalcoholic steatohepatitis, and metabolic syndrome. Mouse models suggest that ACLY inhibition could reduce inflammation and kidney fibrosis.
Mohammadi-Shemirani, P, Chong, M, Perrot, N, Pigeyre, M, Steinberg, GR, Paré, G, Krepinsky, JC, Lanktree, MB   +7 more
openaire   +3 more sources

Causal relationship between obesity and iron deficiency anemia: a two-sample Mendelian randomization study

Frontiers in Public Health, 2023
BackgroundObservational studies have suggested an association between obesity and iron deficiency anemia, but such studies are susceptible to reverse causation and residual confounding.
Tingting Wang, Qi Gao, Yuanyuan Yao, Ge Luo, Tao Lv, Guangxin Xu, Mingxia Liu, Jingpin Xu, Xuejie Li, Dawei Sun, Zhenzhen Cheng, Ying Wang, Chaomin Wu, Ruiyu Wang, Jingcheng Zou, Min Yan   +15 more
doaj   +1 more source

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis [PDF]

, 2020
Background A non-invasive method to grade the severity of steatohepatitis and liver fibrosis is magnetic resonance imaging (MRI) based corrected T1 (cT1).
Banerjee, R, Banerjee, R, Bell, J.D., Bell, J.D., Hemingway, H., Hemingway, H., Hingorani, A.D., Hingorani, A.D., Kelly, M., Kelly, M., McGonigle, J., McGonigle, J., Neubauer, S., Neubauer, S., Nicholls, R.C., Nicholls, R.C., Parisinos, C.A., Parisinos, C.A., Patel, R.S., Patel, R.S., Thomas, E.L., Thomas, E.L., Wilman, H., Wilman, H., Yaghootkar, H., Yaghootkar, H.   +25 more
core   +3 more sources

Mendelian randomization analysis with survival outcomes

Genetic Epidemiology, 2020
AbstractMendelian randomization (MR) is an established approach for assessing the causal effects of heritable exposures on outcomes. Outcomes of interest often include binary clinical endpoints, but may also include censored survival times. We explore the implications of both the Cox proportional hazard model and the additive hazard model in the ...
Cho, Youngjoo, Rau, Andrea, Reiner, Alex, Auer, Paul   +3 more
openaire   +4 more sources

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

BMC Genomics, 2023
Background Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to ...
Chuan Zeng, Chaolong Zhang, Chunming He, Haimin Song   +3 more
doaj   +1 more source

Mendelian randomization and pleiotropy analysis

Quantitative Biology, 2021
BackgroundMendelian randomization (MR) analysis has become popular in inferring and estimating the causality of an exposure on an outcome due to the success of genome wide association studies. Many statistical approaches have been developed and each of these methods require specific assumptions.ResultsIn this article, we review the pros and cons of ...
openaire   +3 more sources