Results 11 to 20 of about 1,141,533 (358)

Modifiable factors for migraine prophylaxis: A mendelian randomization analysis

Frontiers in Pharmacology, 2023
Objective: To examine the causal effect of potentially modifiable risk factors contributing to migraine pathogenesis. Methods: We performed Mendelian randomization analyses and acquired data from United Kingdom Biobank, FinnGen Biobank, and the MRC IEU ...
Hui Zheng, Yun-zhou Shi, Jingjing Liang, Liang Lu, Min Chen   +4 more
semanticscholar   +4 more sources

Dietary factors and hypertension: A Mendelian randomization analysis

Food Science & Nutrition
This research explores the causal link between dietary habits and hypertension through Mendelian randomization, providing distinct perspectives on the role of diet in addressing this worldwide health issue.
Fanfan Li, Wenwen Yang, Shuo Sun, Wenhui He, Shangqing Xu, Biao Han, Minjie Ma   +6 more
semanticscholar   +4 more sources

Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis [PDF]

BMC Medicine, 2022
Background Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias.
Emmanouil Bouras, V. Karhunen, D. Gill, Jian Huang, P. Haycock, M. Gunter, M. Johansson, P. Brennan, T. Key, S. Lewis, Richard M. Martin, N. Murphy, E. Platz, R. Travis, J. Yarmolinsky, V. Zuber, P. Martin, M. Katsoulis, H. Freisling, T. Nøst, M. Schulze, L. Dossus, R. Hung, C. Amos, Ari V. Ahola-Olli, Saranya Palaniswamy, M. Männikkö, J. Auvinen, K. Herzig, S. Keinänen-Kiukaanniemi, T. Lehtimäki, V. Salomaa, O. Raitakari, M. Salmi, S. Jalkanen, CRUK CAPS PEGASUS, Cruk, Caps, Pegasus, M. Jarvelin, A. Dehghan, K. Tsilidis   +41 more
semanticscholar   +14 more sources

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis [PDF]

PLoS Medicine, 2013
The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach.We used the adiposity ...
Tove Fall, Sara Hägg, Reedik Mägi, Alexander Ploner, Krista Fischer, Momoko Horikoshi, Antti‐Pekka Sarin, Guðmar Þorleifsson, Claes Ladenvall, Mart Kals, Maris Kuningas, Harmen H. M. Draisma, Janina S. Ried, Natalie R. van Zuydam, Ville Huikari, Massimo Mangino, Emily Sonestedt, Beben Benyamin, Christopher P. Nelson, Natalia V. Rivera, Kati Kristiansson, Huei-Yi Shen, Aki S. Havulinna, Abbas Dehghan, Louise A. Donnelly, Marika Kaakinen, Marja-Liisa Nuotio, Neil Robertson, Renée F.A.G. de Bruijn, M. Arfan Ikram, Najaf Amin, Anthony J. Balmforth, Peter S. Braund, Alex S. F. Doney, Angela Döring, Paul Elliott, Tõnu Esko, Oscar H. Franco, Sólveig Grétarsdóttir, Anna‐Liisa Hartikainen, Kauko Heikkilä, Karl‐Heinz Herzig, Hilma Hólm, Jouke‐Jan Hottenga, Elina Hyppönen, Thomas Illig, Aaron Isaacs, Bo Isomaa, Lennart C. Karssen, Johannes Kettunen, Wolfgang Köenig, Kari Kuulasmaa, Tiina Laatikainen, Jaana Laitinen, Cecilia M. Lindgren, Valeriya Lyssenko, Esa Läärä, Nigel W. Rayner, Satu Männistö, Anneli Pouta, Wolfgang Rathmann, Fernando Rivadeneira, Aimo Ruokonen, Markku J. Savolainen, Eric J.G. Sijbrands, Kerrin S. Small, Jan Smit, Valgerður Steinthórsdóttir, Ann‐Christine Syvänen, Anja Taanila, Martin D. Tobin, André G. Uitterlinden, Sara M. Willems, Gonneke Willemsen, Jacqueline C.M. Witteman, Markus Perola, Alun Evans, Jean Ferrières, Jarmo Virtamo, Frank Kee, David‐Alexandre Trégouët, Dominique Arveiler, Philippe Amouyel, Maurizio Ferrario, Paolo Brambilla, Alistair S. Hall, Andrew C. Heath, Pamela A. F. Madden, Nicholas G. Martin, Grant W. Montgomery, John B. Whitfield, Antti Jula, Paul Knekt, Ben A. Oostra, Cornelia M. van Duijn, Brenda W.J.H. Penninx, George Davey Smith, Jaakko Kaprio, Nilesh J. Samani, Christian Gieger   +99 more
  +19 more sources

A General Approach to Sensitivity Analysis for Mendelian Randomization

Statistics in Biosciences, 2020
Mendelian Randomization (MR) represents a class of instrumental variable methods using genetic variants. It has become popular in epidemiological studies to account for the unmeasured confounders when estimating the effect of exposure on outcome. The success of Mendelian Randomization depends on three critical assumptions, which are difficult to verify.
Weiming Zhang, Debashis Ghosh
openalex   +4 more sources

Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis [PDF]

Scientific Reports, 2017
AbstractObservational studies suggest associations of triglyceride levels with longevity and frailty. This study aimed to test whether the associations are causal. We used data from the Rugao Longevity and Ageing Study, a population-based cohort study performed in Rugao, China.
Zuyun Liu, Stephen Burgess, Zhengdong Wang, Wan Deng, Xue‐Feng Chu, Jian Cai, Yin‐Sheng Zhu, Jianming Shi, Xuejuan Xie, Yong Wang, Jin Li, Xiaofeng Wang   +11 more
openalex   +5 more sources

Leukemia and risk of stroke: a Mendelian randomization analysis. [PDF]

BMC Neurol
Observational studies suggest an association between leukemia and stroke, but causality remains unclear. Certain leukemia types may increase stroke risk, but variations exist in stroke and mortality rates across leukemia subtypes. This study employed Mendelian randomization (MR) to investigate links between leukemia subtypes and stroke.We conducted a ...
Yi X, Zhu J, Zhang X, Huang N, Cheng Y.
europepmc   +4 more sources

Smoking and heart failure: a Mendelian randomization and mediation analysis [PDF]

ESC Heart Failure, 2021
AbstractAimsWe performed a Mendelian randomization (MR) study to elucidate the associations of ever smoking, lifelong smoking duration, and smoking cessation with heart failure (HF) risk.Methods and resultsWe extracted genetic variants associated with smoking initiation, age at initiation of regular smoking, cigarettes per day, and smoking cessation ...
Hefeng Lin, Yunlong Lu, Marios K. Georgakis, Zhouming Xu, Zhen Wang, Liangrong Zheng   +5 more
openaire   +3 more sources

ACLY and CKD: A Mendelian Randomization Analysis

Kidney International Reports, 2022
Adenosine triphosphate-citrate lyase (ACLY) inhibition is a therapeutic strategy under investigation for atherosclerotic cardiovascular disease, nonalcoholic steatohepatitis, and metabolic syndrome. Mouse models suggest that ACLY inhibition could reduce inflammation and kidney fibrosis.
Mohammadi-Shemirani, P, Chong, M, Perrot, N, Pigeyre, M, Steinberg, GR, Paré, G, Krepinsky, JC, Lanktree, MB   +7 more
openaire   +3 more sources

Selenium and cancer risk: Wide‐angled Mendelian randomization analysis [PDF]

International Journal of Cancer, 2021
AbstractEvidence on the association between selenium and cancer risk is inconclusive. We conducted a Mendelian randomization study to examine the associations of selenium levels with 22 site‐specific cancers and any cancer. Single nucleotide polymorphisms (SNPs) strongly associated with toenail and blood (TAB) and blood selenium levels in mild linkage ...
Yuan, Shuai, Mason, Amy, Carter, Paul, Vithayathil, Mathew, Kar, Siddhartha, Burgess, Stephen, Larsson, Susanna C   +6 more
openaire   +5 more sources