Results 211 to 220 of about 72,268 (331)

A century of theories of balancing selection

Biological Reviews, EarlyView.
ABSTRACT Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short.
Filip Ruzicka, Martyna K. Zwoinska, Debora Goedert, Hanna Kokko, Xiang‐Yi Li Richter, Iain R. Moodie, Sofie Nilén, Colin Olito, Erik I. Svensson, Peter Czuppon, Tim Connallon   +10 more
wiley   +1 more source

Identification of Novel Protein Biomarkers and Drug Targets for Acne Vulgaris by Integrating Human Plasma Proteome with Genome-Wide Association Data

Journal of Inflammation Research
Dongrui Xu,1,* Xiaoyi Yang,1,* Wenjuan Wu,2 Jiankang Yang1 1School of Basic Medical Sciences, Dali University, Dali, Yunnan, People’s Republic of China; 2Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming,
Xu D, Yang X, Wu W, Yang J
doaj  

Genetically Validated Immune Susceptibility Markers for Crohn's Disease: A Multi-Omics Mendelian Randomization Analysis. [PDF]

JGH Open
Li Z.
europepmc   +1 more source

Effect Modification by Cofactors in the Impact of Body Mass Index Change on the Risk of Lung Cancer

Cancer Science, EarlyView.
Persistent overweight or obesity, and BMI gain from normal to overweight or obesity, were consistently associated with reduced lung cancer risk, with stronger associations among men and ever smokers. Persistent underweight and BMI loss were associated with increased lung cancer risk, particularly in men. The protective effect of obesity and BMI gain is
Su Youn Nam, Junwoo Jo, Sun Ha Choi
wiley   +1 more source

Plasma proteins and osteosarcoma: Mendelian randomization analysis and targeted therapeutic discovery. [PDF]

Medicine (Baltimore)
Zhao L, Shen J, Zheng X, Yuan Q, Ye J.
europepmc   +1 more source

A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder [PDF]

, 2017
Bierut, Laura J, et al,, Rice, John P, Saccone, Nancy L   +3 more
core   +1 more source

The Causal Association Analysis between Depression and Cerebrospinal Fluid: From the Perspective of Mendelian Randomization

Yu Zhang, Ping Wu, Zhuo Liu
openalex   +2 more sources

Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Background Glycaemic traits are associated with poorer brain health and dementia risk. Recent advances in genetic instruments for specific glycaemic markers enable an in‐depth investigation of the likely nature of associations and underlying mechanisms between diabetes‐related mechanisms and brain health and dementia.
Andrew C. Mason, Nasri Fatih, Reecha Sofat, Christopher T. Rentsch, Liam Smeeth, Krishnan Bhaskaran, Nish Chaturvedi, Victoria Garfield   +7 more
wiley   +1 more source

Mendelian randomization analysis of lipid-lowering drug targets and neuropsychiatric disorders. [PDF]

Medicine (Baltimore)
Peng S, Liu M, Du F, Li K.
europepmc   +1 more source

Two-sample Mendelian randomization analysis of the causal relationship between lipid metabolism/fatty acid metabolism and pre-eclampsia

Dan Yang, Jin Chen, Xiaoyin Wang, Lin Zhuang, Hongjun Feng, Xue Liao, Ting Mo   +6 more
openalex   +2 more sources