Results 211 to 220 of about 1,141,533 (358)

Multi‐Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences

open access: yesAging Cell, EarlyView.
The connections between epigenetic age acceleration (EAA) and the multi‐ome, as well as the extent to which these connections are driven by genetic and environmental factors, remain underexplored. We identified blood proteins, metabolites, and exposures associated with EAA in young adults and, using twin study designs, show that these associations are ...
Gabin Drouard   +5 more
wiley   +1 more source

Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans [PDF]

open access: gold, 2021
Opeyemi Soremekun   +6 more
openalex   +1 more source

Dietary Selenium Deficiency Accelerates the Onset of Aging‐Related Gut Microbial Changes in Aged Telomere‐Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency‐Induced Type 2 Diabetes

open access: yesAging Cell, EarlyView.
Gut Akkermansia muciniphila is enriched by dietary selenium deficiency in aged telomere‐humanized mice and counteracts dietary selenium deficiency‐induced type 2 diabetes. ABSTRACT Previous studies have shown that dietary selenium (Se) deficiency in mice reshapes gut microbiota, exacerbates healthspan deterioration (e.g., type 2 diabetes), and ...
Ying‐Chen Huang   +16 more
wiley   +1 more source

Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis

open access: green, 2020
Yann Ilboudo   +9 more
openalex   +2 more sources

Microbiological Foundations to Optimise Intrinsic Capacity and Promote Healthy Ageing: An Integration Into the Life Course Approach

open access: yesAging Cell, EarlyView.
Gut microbiota composition may influence trajectories of intrinsic capacity throughout life. Factors that positively or negatively impact gut microbiota (determining eubiosis or dysbiosis, respectively) can affect health, potentially acting through short‐chain fatty acids and their metabolic and anti‐inflammatory functions.
Christoph Benner   +2 more
wiley   +1 more source

Nonalcoholic Fatty Liver Disease and Estimated Insulin Resistance in Obese Youth: A Mendelian Randomization Analysis

open access: bronze, 2020
Anita Morandi   +8 more
openalex   +1 more source

The relative contributions of obesity, vitamin D, leptin, and adiponectin to multiple sclerosis risk: A Mendelian randomization mediation analysis [PDF]

open access: green, 2021
Adil Harroud   +6 more
openalex   +1 more source

Telomere Length, Epigenetic Age Acceleration, and Mortality Risk in US Adult Populations: An Additive Bayesian Network Analysis

open access: yesAging Cell, EarlyView.
Epigenetic DNA methylation‐based (DNAm) clocks, particularly GrimAge epigenetic age acceleration, outperform telomere length in predicting mortality across three US cohorts. Using Additive Bayesian Networks, we uncovered complex links among biological aging markers, sex, race, and mortality risk, highlighting the utility of DNAm‐based biomarkers in ...
May A. Beydoun   +11 more
wiley   +1 more source

Systematic Multi‐Trait Study of Genetic Correlation and Causality Relationships Between General Medical Conditions and Mental Disorders

open access: yesActa Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Increasing evidence has highlighted bidirectional associations between mental disorders and general medical conditions, with underlying causes ranging from lifestyle habits and side effects from medications to genetic contributions. Novel methods now provide a way to estimate the shared genetic underpinnings and the possibility of
Ron Nudel   +2 more
wiley   +1 more source

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