Results 21 to 30 of about 1,141,533 (358)

Mendelian randomization analysis with survival outcomes

Genetic Epidemiology, 2020
AbstractMendelian randomization (MR) is an established approach for assessing the causal effects of heritable exposures on outcomes. Outcomes of interest often include binary clinical endpoints, but may also include censored survival times. We explore the implications of both the Cox proportional hazard model and the additive hazard model in the ...
Paul L. Auer, Alexander P. Reiner, Andrea Rau, Andrea Rau, Youngjoo Cho   +4 more
openaire   +6 more sources

Two-Sample Mendelian Randomization Analysis Investigates Causal Associations Between Gut Microbial Genera and Inflammatory Bowel Disease, and Specificity Causal Associations in Ulcerative Colitis or Crohn’s Disease

Frontiers in Immunology, 2022
Background Intestinal dysbiosis is associated with inflammatory bowel disease (IBD). Ulcerative colitis (UC) and Crohn’s disease (CD), two subtypes of IBD, are characterized by unique microbial signatures, respectively.
Bin Liu, D. Ye, Hong Yang, Jie Song, Xiaohui Sun, Y. Mao, Zhixing He   +6 more
semanticscholar   +1 more source

Meta‐analysis andMendelianrandomization: A review [PDF]

Research Synthesis Methods, 2019
Mendelian randomization (MR) uses genetic variants as instrumental variables to infer whether a risk factor causally affects a health outcome. Meta‐analysis has been used historically in MR to combine results from separate epidemiological studies, with each study using a small but select group of genetic variants.
Bowden, J, Holmes, MV
openaire   +6 more sources

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study

BMC Genomics, 2023
Background Currently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to ...
Chuan Zeng, Chaolong Zhang, Chunming He, Haimin Song   +3 more
doaj   +1 more source

Causal relationships of circulating amino acids with cardiovascular disease: a trans-ancestry Mendelian randomization analysis

Journal of Translational Medicine, 2023
Background Epidemiological studies demonstrated that multiple amino acids (AAs) were associated with cardiovascular diseases (CVDs), but whether these associations were causal remains unclear.
Song Hu, Zhennan Lin, Meng-Jin Hu, Jiangshan Tan, Ting-Ting Guo, Xin Huang, L. Hua   +6 more
semanticscholar   +1 more source

Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis

Cardiovascular Diabetology, 2023
Background Emerging evidence suggests that remnant cholesterol (RC) is strongly associated with an increased incidence of cardiometabolic diseases (CMD). However, the causality have not been confirmed.
Baoyi Guan, Anlu Wang, Hao Xu
semanticscholar   +1 more source

Mendelian randomization and pleiotropy analysis

Quantitative Biology, 2021
BackgroundMendelian randomization (MR) analysis has become popular in inferring and estimating the causality of an exposure on an outcome due to the success of genome wide association studies. Many statistical approaches have been developed and each of these methods require specific assumptions.ResultsIn this article, we review the pros and cons of ...
openaire   +4 more sources

Blood lipids and prostate cancer: a Mendelian randomization analysis [PDF]

Cancer Medicine, 2016
AbstractGenetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer cases and 22,133 controls from 22 studies within the international PRACTICAL consortium were analyzed. Allele scores based on
Graham G. Giles, Graham G. Giles, Børge G. Nordestgaard, Stephen N. Thibodeau, J. Brent Richards, J. Brent Richards, Richard M. Martin, Carolina Bonilla, Caroline J. Bull, Ruth C. Travis, Ali Amin Al Olama, George Davey Smith, Hardev Pandha, Agnieszka Micheal, David E. Neal, Jeffrey M P Holly, Fredrik Wiklund, Doug Easton, Claire M Perks, Hermann Brenner, Christiane Maier, Sara Benlloch, Sarah J Lewis, William J. Blot, Manuel R. Teixeira, Philip C Haycock, Oriana Hoi Yun Yu, Jyotsna Batra, Radka Kaneva, Henrik Grönberg, Kay-Tee Khaw, Robert J. MacInnis, Robert J. MacInnis, Adam S. Kibel, Adam S. Kibel, Jong Hyuk Park, Janet L. Stanford, Janet L. Stanford, Lisa A. Cannon-Albright, Zsofia Kote-Jarai, Kenneth Muir, Kenneth Muir, Kenneth Muir, Rosalind A. Eeles, Rosalind A. Eeles, Cezary Cybulski, Johanna Schleutker, Johanna Schleutker, Christopher A. Haiman, Neil M Davies, Nora Pashayan   +50 more
openaire   +8 more sources

MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data [version 2; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research, 2020
The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or
Jim R. Broadbent, Christopher N. Foley, Andrew J. Grant, Amy M. Mason, James R. Staley, Stephen Burgess   +5 more
doaj   +1 more source

No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis

Frontiers in Immunology, 2022
Objectives Periodontitis (PD) has been linked to arthritis in previous epidemiological observational studies; however, the results are inconclusive. It remains unclear whether the association between PD and arthritis is causal.
K. Yin, Ji-Xiang Huang, Peng Wang, Xiao-Ke Yang, Sha-Sha Tao, Hong-Miao Li, J. Ni, Hai-Feng Pan   +7 more
semanticscholar   +1 more source