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The Drainage Dysfunction of Meningeal Lymphatic Vessels Is Correlated with the Recurrence of Chronic Subdural Hematoma: a Prospective Study

Translational Stroke Research, 2023
Meningeal lymphatic vessels (mLVs) were recently discovered to be involved in the waste drainage process in the brain, which has also been associated with a variety of neurological diseases. This research paper hypothesizes that the drainage function of mLVs may be affected after chronic subdural hematoma (CSDH) and the alterations of mLVs' drainage ...
Jiahao Zhang   +14 more
openaire   +2 more sources

Improving the Function of Meningeal Lymphatic Vessels to Promote Brain Edema Absorption after Traumatic Brain Injury

Journal of Neurotrauma, 2023
Brain edema is the most common and fatal complication after traumatic brain injury (TBI). Meningeal lymphatic vessels (MLVs) are the conduits that transport cerebrospinal fluid (CSF) and macromolecules to deep extracranial cervical lymph nodes (dCLNs). After TBI, the drainage function of MLVs can become impaired.
Jianwen, Liao   +7 more
openaire   +2 more sources

Dural Macrophages in The Regulation of Meningeal Lymphatic Vessel Structure and Brain Lymph Drainage

2023
Meningeal lymphatic vessels (mLVs) are the primary route for cerebrospinal fluid (CSF) outflow from the brain. Importantly, dysfunction of mLVs in mice has been shown to increase toxic protein accumulation, resulting in a decline in neurocognitive processing.
openaire   +2 more sources

Evaluation of glymphatic-meningeal lymphatic system with intravenous gadolinium-based contrast-enhancement in cerebral small-vessel disease

European Radiology, 2023
To investigate the feasibility of using noninvasive neuroimaging methods in visualizing and evaluating the clearance of the glymphatic-meningeal lymphatic system (GMLS) in patients with arteriosclerotic cerebral small-vessel disease (CSVD) and controls.This observational study recruited patients with high-burden CSVD and controls (age 50-80 years).
Miaoyi Zhang   +8 more
openaire   +2 more sources

Yuanzhi Powder Facilitated the Aβ Clearance in App/Ps1 Mice: Target to the Drainage of Glymphatic System and Meningeal Lymphatic Vessels

Journal of Ethnopharmacology, 2023
Yuanzhi Powder (YZP) is a classical Chinese medicine prescription, which is suitable for the treatment of dementia by "dispelling phlegm and opening orifice". The therapeutic efficacy of YZP on Alzheimer's disease (AD) has been previously reported in our work.
Jiaxin, Li   +7 more
openaire   +2 more sources

Dynamics of Evans blue clearance from cerebrospinal fluid into meningeal lymphatic vessels and deep cervical lymph nodes

Neurological Research, 2018
Objectives Recently, it has been confirmed, that excess fluid and waste products from the brain are drained into the cerebrospinal fluid (CSF) and afterwards cleared via the olfactory route and/or lymphatic vessels in the brain dura and corresponding extracranial lymphatic structures.
Eva Petrovova   +8 more
openaire   +2 more sources

Vitamin D accelerates the subdural hematoma clearance through improving the meningeal lymphatic vessel function

Molecular and Cellular Biochemistry
Subdural hematoma (SDH) drains into the extracranial lymphatic system through the meningeal lymphatic vessels (mLVs) but the formation of SDH impairs mLVs. Because vitamin D (Vit D) can protect the endothelial cells, we hypothesized that Vit D may enhance the SDH clearance.
Yupeng, Chen   +12 more
openaire   +2 more sources

Image Analysis for Describing Meningeal Lymphatic Vessel Morphology

2020
Neuroscientists have recently discovered the existence of meningeal lymphatic vessels in the brain and have shown their importance in preventing cognitive decline. With age, lymphatic vessels narrow, poorly draining cerebrospinal and interstitial fluids, which leads to plaque accumulation, a hallmark of Alzheimer’s disease.
openaire   +1 more source

Advances in Research on Meningeal Lymphatic Vessels in Central Nervous System Diseases

Journal of Craniofacial Surgery
Meningeal lymphatic vessels (mLVs), located around the dural sinuses, are considered significant participants in cerebrospinal fluid (CSF) circulation. Meningeal lymphatic vessels not only drain fluids and metabolic waste from the brain into deep cervical lymph nodes (dCLNs) but also transport immune cells from the brain to dCLNs, thus regulating the ...
Huimin Shen   +6 more
openaire   +1 more source

Comparative study of 3D-T2WI vs. 3D-T2-FLAIR MRI in displaying human meningeal lymphatics vessels

Clinical Radiology
Various magnetic resonance imaging (MRI) sequences can be utilized to visualize human meningeal lymphatic vessels (MLVs) for investigating the associations between MLVs and central nervous system (CNS) disorders. This study aimed to compare the quality of contrast-enhanced 3D-T2WI and 3D-T2-fluid-attenuated inversion recovery (FLAIR) MRI sequences to ...
Y. Fang   +7 more
openaire   +2 more sources

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