Results 151 to 160 of about 6,220 (169)

Emerging Roles of Meningeal Lymphatic Vessels in Ischemic Stroke

Molecular Neurobiology
This review highlights the emerging relevance of meningeal lymphatic vessels (MLVs) in the context of ischemic stroke, challenging the conventional view of a privileged immunological central nervous system. MLVs facilitate immunological surveillance by modulating the entry of peripheral immune cells into the meningeal compartment, a process not impeded
Richard Simon, Machado, Khiany, Mathias, Larissa, Joaquim, Maiara de Aguiar, da Costa, Anita, Tiscoski, Cinara Ludvig, Gonçalves, Gislaine Tezza, Rezin, Fabricia, Petronilho   +7 more
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Continuous theta burst stimulation dilates meningeal lymphatic vessels by up-regulating VEGF-C in meninges

Neuroscience Letters, 2020
Lymphatic vessels (LVs) of meninges and lymphatic drainage in the brain have been investigated previously. Here, we examined the role of continuous theta burst stimulation (CTBS) in the modulation of meningeal LVs.To explore the effects of CTBS on meningeal LVs, the diameters of LVs were measured between a real CTBS group and sham CTBS group of wild ...
Meng-Ni, Li, Ying-Hua, Jing, Cheng, Wu, Xue, Li, Feng-Yin, Liang, Ge, Li, Pei, Dai, Hui-Xian, Yu, Zhong, Pei, Guang-Qing, Xu, Yue, Lan   +10 more
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Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system

Nature Neuroscience, 2022
Recent studies have demonstrated that brain meningeal lymphatic vessels (MLVs) act as a drainage path directly into the cervical lymph nodes (CLNs) for macromolecules contained in the cerebrospinal fluid (CSF). However, the role of MLVs during CNS viral infection remains unexplored. Here, we found that infection with several neurotropic viruses in mice
Xiaojing Li, Linlin Qi, Dan Yang, ShuJie Hao, Fang Zhang, Xingguo Zhu, Yue Sun, Chen Chen, Jing Ye, Jing Yang, Ling Zhao, Daniel M. Altmann, Shengbo Cao, Hongyan Wang, Bin Wei   +14 more
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Impaired meningeal lymphatic vessels exacerbate early brain injury after experimental subarachnoid hemorrhage

Brain Research, 2021
Blood that enters the subarachnoid space (SAS) and its breakdown products are neurotoxic and are the principal inducers of brain injury after subarachnoid hemorrhage (SAH). Recently, meningeal lymphatic vessels (MLVs) have been proven to play an important role in clearing erythrocytes that arise from SAH, as well as other macromolecular solutes ...
Quanlei, Liu, Changkai, Hou, Hao, Zhang, Cong, Fu, Weihan, Wang, Bangyue, Wang, Jian, Li, Yan, Zhao, Xinyu, Yang   +8 more
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Image Analysis for Describing Meningeal Lymphatic Vessel Morphology

2020
Neuroscientists have recently discovered the existence of meningeal lymphatic vessels in the brain and have shown their importance in preventing cognitive decline. With age, lymphatic vessels narrow, poorly draining cerebrospinal and interstitial fluids, which leads to plaque accumulation, a hallmark of Alzheimer’s disease.
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Advances in Research on Meningeal Lymphatic Vessels in Central Nervous System Diseases

Journal of Craniofacial Surgery
Meningeal lymphatic vessels (mLVs), located around the dural sinuses, are considered significant participants in cerebrospinal fluid (CSF) circulation. Meningeal lymphatic vessels not only drain fluids and metabolic waste from the brain into deep cervical lymph nodes (dCLNs) but also transport immune cells from the brain to dCLNs, thus regulating the ...
Huimin, Shen, Bingrui, Zhu, Yajun, Qian, Jiancheng, Jin, Jiankuai, Zhou, Guotao, Peng, Jun, Mo   +6 more
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Abstract P346: Expansion of meningeal lymphatic vessels in DOCA-salt hypertension

Hypertension
The meningeal lymphatic system is critical for proper brain waste clearance and maintenance of the local meningeal neuroimmune niche. Meningeal lymphatic function is impaired during aging and neurodegenerative diseases and is associated with the development of cognitive impairment.
Melissa Sobanko, Monica Santisteban
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Meningeal Lymphatic Vessels Contribute to Microglia Activation and Behavioral Response to Peripheral Inflammation

2022
The recently discovered meningeal lymphatic system represents a potential point of access to the brain from the immune system that remains unexplored in the context of sickness behavior. Publications from our lab have established that meningeal lymphatic vessels facilitate solute clearance from the brain parenchyma and that these vessels deteriorate ...
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Evaluation of Glymphatic-Meningeal Lymphatic Vessels with delayed contrast enhanced vessel-wall MRI in Cerebral Infarction

ISMRM Annual Meeting
Motivation: To observe clearance pathways in patients with cerebral infarction. Goal(s): The goal of this study is to identify novel in vivo human findings regarding the clearance pathways in patients with cerebral infarction. Approach: 3D T1 DANTE SPACE imaging was performed 1-5 hours after intravenous injection of gadolinium-based contrast agent ...
Masaki Umehana, Yasutaka Fushimi, Sachi Okuchi, Sayo Otani, Akihiko Sakata, Takayuki Yamamoto, Satoshi Nakajima, Satoshi Ikeda, Shuichi Ito, Yongping Ma, Shin Morooka, John Grinstead, Sinyeob Ahn, Katsuhiko Mitsumoto, Yuji Nakamoto   +14 more
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Vitamin D accelerates the subdural hematoma clearance through improving the meningeal lymphatic vessel function

Molecular and Cellular Biochemistry
Subdural hematoma (SDH) drains into the extracranial lymphatic system through the meningeal lymphatic vessels (mLVs) but the formation of SDH impairs mLVs. Because vitamin D (Vit D) can protect the endothelial cells, we hypothesized that Vit D may enhance the SDH clearance.
Yupeng, Chen, Xuanhui, Liu, Jiangyuan, Yuan, Shiying, Dong, Meng, Nie, Weiwei, Jiang, Di, Wu, Mingqi, Liu, Tao, Liu, Chenrui, Wu, Chuang, Gao, Jianning, Zhang, Rongcai, Jiang   +12 more
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