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Understanding the Mechanisms that Modulate the MEP Pathway in Higher Plants
2012The methyl-d-erythritol 4-phosphate (MEP) pathway is responsible for the biosynthesis of an impressive number of natural compounds of biological and biotechnological importance. In recent years, this pathway has become a clear target to develop new herbicides and antimicrobial drugs. Additionally, the production of a variety of compounds of medical and
Patricia Leon
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Combinational biosynthesis of isoprene by engineering the MEP pathway in Escherichia coli
Process Biochemistry, 2014Abstract As an important feedstock in petrochemistry, isoprene is used in a wide range of industrial applications. It is produced almost entirely from petrochemical sources; however, these sources are being progressively depleted. A reliable biological process for isoprene production utilizing renewable feedstocks would be an industry-redefining ...
Chun-Li Liu, Li-Hai Fan
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The expression of TwDXS in the MEP pathway specifically affects the accumulation of triptolide
Physiologia Plantarum, 20191‐Deoxy‐d‐xylulose‐5‐phosphate synthase (DXS) is the first enzyme in the plant 2‐C‐methyl‐d‐erythritol 4‐phosphate (MEP) pathway of terpenoid synthesis. TwDXS is a prominent protein in the Tripterygium wilfordii proteome, with especially high expression in the root periderm. It is significantly regulated by methyl jasmonate.
Yifeng Zhang +8 more
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The MEP pathway and the development of inhibitors as potential anti-infective agents
MedChemComm, 2012The non-mevalonate (or MEP) pathway represents an essential biosynthetic route used by plants, algae, and eubacteria to generate isoprenoid precursors. The MEP pathway has also been genetically validated in pathogenic organisms such as P. falciparum and M. tuberculosis.
Ian Hale +4 more
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Cloning and expression of cDNAs encoding two enzymes of the MEP pathway in Catharanthus roseus
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2000Two periwinkle cDNAs (crdxr and crmecs) encoding enzymes of the non-mevalonate terpenoid pathway were characterized using reverse transcription-PCR strategy based on the design of degenerated oligonucleotides. The deduced amino acid sequence of crdxr is homologue to 1-deoxy-D-xylulose 5-phosphate reductoisomerases.
B, Veau +5 more
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The MEP Pathway: A New Target for the Development of Herbicides, Antibiotics and Antimalarial Drugs
Current Pharmaceutical Design, 2004Isoprenoids, a diverse group of compounds derived from the five-carbon building units isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP), are essential for survival in all organisms. Animals synthesize their isoprenoids from mevalonic acid (MVA), whereas most pathogenic bacteria and the malaria parasites utilize a completely
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Investigating structural insights and inhibitor strategies in MEP pathway enzymes
Arzneimittelresistente Infektionen stellen eine erhebliche Bedrohung für die menschliche Gesundheit dar. Studien prognostizieren, dass sie in den nächsten 30 Jahren die führende Todesursache werden könnten. Daher besteht ein dringender Bedarf, neue antimikrobielle Wirkstoffe zu entdecken.openaire +1 more source
The MEP Pathway Is Activated In Response To Pathogen Infection In Rice
Plant and Cell Physiology Supplement, 2006Okada, Kazunori +5 more
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