Results 81 to 90 of about 10,401 (200)

Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab [PDF]

, 2008
BACKGROUND The hypereosinophilic syndrome is a group of diseases characterized by persistent blood eosinophilia, defined as more than 1500 cells per microliter with end-organ involvement and no recognized secondary cause.
Frewer, Paul I. H., Gleich, Gerald J., Griffin, Elaine F., Haig, Ann E., Kahn, Jean E., Klion, Amy D., Parkin, Jacqueline M., Ring, Johannes, Rosenwasser, Lanny J., Rothenberg, Marc E., Roufosse, Florence E., Schwartz, Lawrence B., Simon, Hans-Uwe, Weller, Peter F.   +13 more
core   +1 more source

Rhinology future debates, an EUFOREA report [PDF]

, 2017
The first Rhinology Future Debates was held in Brussels in December 2016, organized by EUFOREA (European Forum for Research and Education in Allergy and Airways diseases).
Bachert, Claus, Bernal-Sprekelsen, Manuel, Bousquet, Jean, Djandji, Michel, Dorenbaum, Alejandro, Fokkens, Wytske J, Hakim-Mehr, Dorna, Hellings, Peter W, Hendry, Stuart, Hopkins, Claire, Leunig, Andreas, Mannent, Leda, Mucha, Dirk, Onerci, Metin, Pugin, Benoit, Rowe, Paul, Seys, Sven F, Stimson, Susan, Strzembosz, Agnieszka, Toppila-Salmi, Sanna   +19 more
core   +2 more sources

Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications—An EAACI Task Force Report

Allergy, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS) and asthma are prevalent conditions that often coexist. These diseases share common inflammatory mechanisms, such as T‐helper cell 2 (T2)‐high inflammation, driven by interleukin (IL)‐4, IL‐5, and IL‐13 cytokines.
Sanna Toppila‐Salmi, Sietze Reitsma, Valérie Hox, Simon Gane, Philippe Gevaert, Juan Maza‐Solano, Alma Helevä, Ida Sulku, Kaisa Santala, Iiris Kangasniemi, Ludger Klimek, Adam Chaker, Aspasia Karavelia, Michael Rudenko, Oliver Pfaar, Laura Van Gerven, Shaari Ariana, Michele Schiappoli, Marie Lundberg, Jan Hagemann, Ibon Eguíluz‐Gracia, Andre Moreira   +21 more
wiley   +1 more source

Early and Sustained Asthma Control and Remission in Real‐World Patients With Severe Eosinophilic Asthma Treated With Benralizumab: XALOC‐2

Clinical &Experimental Allergy, EarlyView.
Real‐world patients with severe eosinophilic asthma treated with benralizumab showed early and sustained improvements in symptoms. Clinically meaningful improvements began as early as one week after benralizumab initiation, regardless of previous biologic use, and further improved over the following year.
Erika Penz, Thomas Rothe, Lieven Dupont, Trung N. Tran, Andrew Menzies‐Gow, Anat Shavit, David Cohen, Tanja Plate, Sheena Kayaniyil, An Herreman, Claudio Schuoler, Benjamin Emmanuel, Marek Lommatzsch   +12 more
wiley   +1 more source

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

Clinical &Experimental Allergy, EarlyView.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna, Christina Morgenstern, Katharina Poglitsch, Tamara Arnoldner, Katharina Gangl, Tina J. Bartosik, Nicholas J. Campion, Aldine Tu, Victoria Stanek, Sven Schneider, Christine Bangert   +10 more
wiley   +1 more source

Wells syndrome: clinical findings and management in a large cohort of 48 patients

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives: Wells syndrome (WS) is a rare inflammatory skin disorder typically characterized by erythematous, edematous, and pruritic plaques. Despite its distinct histopathological features, WS remains an underdiagnosed disease due to its variable clinical presentations and overlap with other dermatological conditions.
Marco Adriano Chessa, Silvia Robuffo, Tullio Brunetti, Luca Rapparini, Bianca Maria Piraccini, Cosimo Misciali, Beatrice Raone, Iria Neri, Federica Filippi   +8 more
wiley   +1 more source

Real-world characteristics and disease burden of patients with asthma prior to treatment initiation with mepolizumab or omalizumab: a retrospective cohort database study

Journal of Asthma and Allergy, 2019
Jean-Pierre Llanos,1 Christopher F Bell,1 Elizabeth Packnett,2 Ellen Thiel,2 Debra E Irwin,2 Beth Hahn,1 Hector Ortega3 1Respiratory, US Medical Affairs, GSK, Research Triangle Park, NC, USA; 2Truven Health Analytics, An IBM Watson Health Company, Ann ...
Llanos JP, Bell CF, Packnett E, Thiel E, Irwin DE, Hahn B, Ortega H   +6 more
doaj  

Modifiable Risk Factors for Symptom Burden in Chronic Rhinosinusitis With Nasal Polyps: The Role of Obesity and Sleep Apnoea

Clinical Otolaryngology, Volume 51, Issue 2, Page 275-284, March 2026.
ABSTRACT Objective To identify sociodemographic and clinical predictors of symptom severity and quality of life (QoL) impairment in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), diagnosed according to the latest EPOS 2020 criteria. Study Design Cross‐sectional analytical study.
Javier Modesto García‐Fernández, María Soledad Sánchez‐Torices, María Pilar Gómez‐Gallego, Miguel Ángel Feliz‐Fernández, María Alharilla Montilla‐Ibáñez, Rafael Lomas‐Vega   +5 more
wiley   +1 more source

Persistent Bacterial Bronchitis: time to venture beyond the Umbrella [PDF]

, 2017
Chronic cough in children is common and frequently mismanaged. In the past, cough was diagnosed as asthma and inappropriate asthma therapies prescribed and esca- lated.
Bush, A
core   +1 more source

Overlapping forms of granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis: Insights from a European multicenter study

Journal of Internal Medicine, Volume 299, Issue 3, Page 349-364, March 2026.
Abstract Background Granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA) are distinct forms of antineutrophil cytoplasm antibody (ANCA)‐associated vasculitis (AAV). Increasing evidence suggests overlapping features, particularly in proteinase 3 (PR3)‐ANCA‐positive EGPA and GPA with eosinophilia.
Federica Pallotti, Camille Mettler, Matthias Papo, Michele Iudici, Roberto Padoan, Boris Sorin, Francesca Regola, Franco Franceschini, Sergey Moiseev, Pavel Novikov, Mario Andrea Piga, Gianluca Moroncini, Silke R. Brix, Abdul Hadi Kafagi, Samuel Deshayes, Achille Aouba, Julien Campagne, Paolo Delvino, Jan Willem Cohen Tervaert, Luisa Brussino, Martin Michaud, Nils Venhoff, Federico Alberici, Claudia Iannone, Sophie Rosenstingl, Marin Moutel, Jean‐Marc Galempoix, Vincent Cottin, Clara Jaccard, Diane Riehl, Paul Legendre, Anne Claire Billet, Paola Parronchi, Luca Quartuccio, Vitor Teixeira, Allyson Egan, David Jayne, Enrico Tombetti, Marco Caminati, Christian Pagnoux, Alexis Regent, Marc Ruivard, Loïc Guillevin, Xavier Puéchal, Benjamin Terrier, the French Vasculitis Study Group (FVSG)   +45 more
wiley   +1 more source