Results 11 to 20 of about 1,567 (140)

Anxiolytic Medication Use in Low- Middle- and High-Income Countries: A World Mental Health Surveys Report. [PDF]

Hum Psychopharmacol
ABSTRACT Background Anxiolytic medications, particularly benzodiazepines, are widely prescribed, giving impetus to long‐standing debates about how often these agents should be employed in clinical practice. There are, however, few cross‐country studies of the pharmacoepidemiology of these agents. We report on the frequency of anxiolytic medication use,
Stein DJ, Kazdin AE, Baldwin DS, Harris MG, Hwang I, Pozuelo JR, Sampson NA, Woodruff P, Viana MC, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Andrade LH, Benjet C, Bruffaerts R, Caldas-de-Almeida JM, Chardoul S, de Girolamo G, Gureje O, Haro JM, Karam EG, Karam A, Kovess-Masfety V, Navarro-Mateu F, Nishi D, Posada-Villa J, Roest A, Stagnaro JC, Vladescu C, Vigo DV, Kessler RC, WHO World Mental Health Survey collaborators.   +31 more
europepmc   +2 more sources

PATOPHYSIOLOGICAL MECHANISM OF PIGMENTED PURPURIC DERMATOSES [PDF]

Sanamed, 2013
Aim: Patophysiological modeling of pigmented purpuric dermatoses based on venous hypertension. Capillaritis are considered to be patophysiological equivalent, or etiological basis of pigmented purpuric dermatoses.
Vujanac Andreja, Djokovic Vesna, Dabetic Snezana, Detanac A. Dzenana   +3 more
doaj   +2 more sources

Drug-facilitated crime: A review of findings between 2019 and 2023. [PDF]

J Forensic Sci
Abstract Drug‐facilitated crime (DFC) is a criminal act (e.g., assault, robbery, or sexual assault) in which the perpetrator uses drugs to impair the victim's ability to resist, remember, or recognize the crime being committed. Ethanol is commonly implicated in DFC casework, but limited data are published on other substances currently implicated in ...
Hessler MR, Kacinko SL, Logan BK.
europepmc   +2 more sources

Long-Term and Seasonal Trends of Wastewater Chemicals in Lake Mead: An Introduction to Time Series Decomposition

Journal of Statistics Education, 2017
A recent paper published time series of concentrations of chemicals in drinking water collected from the bottom of Lake Mead, a major American water supply reservoir. Data were compared to water level using only linear regression.
Richard A. Wildman
doaj   +1 more source

Drug related problems associated with the psychoactive drugs used on geriatric, hospitalized patients

Brazilian Journal of Pharmaceutical Sciences, 2012
A prospective study was carried out, to identify the drug related problems and to prevent or to solve the negative outcomes associated with medication of the geriatric patients that consumed psychoactive drugs, who were hospitalized.
Ortega López Irma Leonor, Verdecia Rosés Miguel Ernesto   +1 more
doaj   +1 more source

Hell's Itch: A Self‐Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a severely distressing dermatological condition characterized by the onset of incessant itching and intolerable pain 2–3 days post‐sunburn. It is underdiagnosed and underreported, and no definitive management framework has yet been developed.
Kai Peter Moors, Willem I. Visser
wiley   +1 more source

The Role of Meprins on the Brain Extracellular Matrix and Perineuronal Nets

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Meprin β overexpression is implicated in Alzheimer's Disease. Recent studies identified brevican as a meprin β substrate, and this study demonstrates that meprin α co‐expression enhances meprin β‐mediated brevican cleavage. Further, neurocan and RPTPζ were identified as novel meprin β substrates in an N‐terminomics analysis of meprin β transgenic mice,
Simon Kreiselmaier, Maximilian Keller, Leonardo Nardi, Constantin Mueller, Nele von Wiegen, Kira Bickenbach, Lea Gröbner, Mohammad Abukhalaf, Andreas Tholey, Margareta M. Mueller, Hagen Körschgen, Michael J. Schmeisser, Christoph Becker‐Pauly, Claus U. Pietrzik   +13 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Targeting ParPMC Susceptibility Hubs in Prunus: eEF1A as a Conserved Mediator of Plum Pox Virus Infection in Nicotiana benthamiana

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
ParPMC interactors were screened, highlighting eEF1A proteins; co‐localization and VIGS show their role in PPV infection and sharka susceptibility. ABSTRACT Sharka, caused by Potyvirus plumpoxi (plum pox virus, PPV), is the most destructive viral disease affecting Prunus species worldwide.
Ángela Polo‐Oltra, Alba Lloret, Jesús A. Sánchez‐Navarro, Gabino Ríos, Carlos Romero, Elena Zuriaga   +5 more
wiley   +1 more source