Results 31 to 40 of about 1,567 (140)

Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease

FASEB BioAdvances, Volume 7, Issue 11, November 2025.
Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur, Sonal Padole, Tapati Sarkar, Somasundaram Arumugam, Shiladitya Chattopadhyay   +4 more
wiley   +1 more source

Human tissue kallikrein 14 induces the expression of IL‐6, IL‐8, and CXCL1 in skin fibroblasts through protease‐activated receptor 1 signaling

The FEBS Journal, Volume 292, Issue 21, Page 5659-5675, November 2025.
Human tissue kallikrein 14 (KLK14), a skin protease, may mediate paracrine signaling in wound healing. KLK14 released by epithelial cells activates fibroblasts via PAR‐1 activation, inducing IL‐6, IL‐8, and CXCL1 expression. These cytokines in turn promote keratinocyte proliferation and migration, resulting in wound closure.
Laura Sasiadek, Ewa Bielecka, Katherine Falkowski, Magdalena Kulczycka, Grzegorz Bereta, Anna Maksylewicz, Natalia Zubrzycka, Ewelina Dobosz, Joanna Kozieł, Justyna Drukała, Maciej Lech, Natalia Horbach, Marcin Poręba, Klaudia Brix, Grzegorz Dubin, Jan Potempa, Tomasz Kantyka   +16 more
wiley   +1 more source

Gas Chromatography of Meprobamate

Clinical Chemistry, 1967
Abstract Rapid detection and precise quantitation of meprobamate in biologic fluid has been accomplished using the gas chromatograph. The method described has proved useful in elvaluating patients intoxicated by this sedative.
R K, Maddock, H A, Bloomer
openaire   +2 more sources

Extrachromosomal Circular DNA as a Cancer Biomarker: From Diagnosis to Treatment

Cancer Innovation, Volume 4, Issue 5, October 2025.
Extrachromosomal circular DNA (eccDNA) is an emerging class of genetic material that exists outside the chromosomal genome. These circular DNA molecules are gaining increasing attention as important biomarkers in cancer research due to their roles in gene amplification, genetic heterogeneity, and drug resistance.
Hexin Li, Jiahui Cai, Gang Zhao, Lihui Zou   +3 more
wiley   +1 more source

Single and Multiple Dose PK-PD Characterization for Carisoprodol. Part I: Pharmacokinetics, Metabolites, and 2C19 Phenotype Influence. Double-Blind, Placebo-Controlled Clinical Trial in Healthy Volunteers. [PDF]

J Clin Med, 2022
Calvo A, Alonso S, Prieto E, Ascaso-Del-Rio A, Ortuño J, Fernandez N, Portolés A.   +6 more
europepmc   +1 more source

Patient with abnormal eye movement. [PDF]

J Am Coll Emerg Physicians Open, 2022
Cheng TH, Chao HY, Tseng JC, Chen HY.
europepmc   +1 more source

Meprobamate [PDF]

, 2020
Louis A. Pagliaro, Ann Marie Pagliaro
openaire   +2 more sources

MEPROBAMATE IN TETANUS

British Journal of Anaesthesia, 1960
openaire   +2 more sources

Unlocking the potential of bone marrow in postmortem forensic toxicology: current evidence and future perspectives. [PDF]

J Anal Toxicol
Vanerio S, Galante N, Ravelli A, Bergamaschi RF, Battistini A, Casati S.   +5 more
europepmc   +1 more source

Leveraging topological indices and machine learning for advanced prediction of antidepressant drug properties. [PDF]

Sci Rep
Zhang G, Noureen S, Azam S, Abdalla MEM, Dafaalla ME, Aslam A, Tola KA.   +6 more
europepmc   +1 more source