Results 101 to 110 of about 403 (128)

The metabolism of carbadox, olaquindox, mequindox, quinocetone and cyadox: an overview.

Medicinal Chemistry, 2013
The aim of this article is to get an overview of the metabolism of quinoxaline 1,4-di-N-oxides (QdNOs) used in food animals. The derivatives of QdNOs (carbadox, olaquindox, mequindox, quinocetone, and cyadox) are the potent synthetic antimicrobial agents that are used for improving the feed efficiency and controlling dysentery in food-producing animals.
Zhao-Ying Liu, Zhi-Liang Sun
semanticscholar   +3 more sources

Metabolism, Distribution, and Elimination of Mequindox in Pigs, Chickens, and Rats.

Journal of Agricultural and Food Chemistry, 2015
Mequindox (MEQ), a quinoxaline-N,N-dioxide antibacterial agent used to control bacterial enteritis in various food-producing animals, is a potential violative residue in food animal-derived products. The disposition and elimination of MEQ in rats, pigs, and chickens was comprehensively investigated to identify the marker residue and target tissue of ...
Lingli Huang, Fu-jun Yin, Yuanhu Pan, Dongmei Chen, Juan Li, D. Wan, Zhenli Liu, Zonghui Yuan   +7 more
semanticscholar   +3 more sources

Dynamic changes in metabolic profiles of rats subchronically exposed to mequindox.

Mol. BioSyst., 2014
Mequindox is widely used as an antibacterial veterinary drug and a feeding additive for farm animals in China. Although its toxicity has been widely studied, little is known regarding the metabolic effects of subchronic exposure to mequindox, which is vital for the health of meat producing livestock.
Limiao Jiang, Xiuju Zhao, Chongyang Huang, Hehua Lei, Huiru Tang, Yulan Wang   +5 more
semanticscholar   +3 more sources

Dynamic metabolic response of mice to acute mequindox exposure.

Journal of Proteome Research, 2011
Mequindox is used as a veterinary antibiotic drug. As part of systematic investigations into mequindox as a veterinary medicine and its subsequent applications in food safety, we conducted the investigation to assess the metabolic response of mice to mequindox using metabonomics, which combines NMR metabolic profiles of biofluids or tissues and pattern
Xiuju Zhao, Chongyang Huang, Hehua Lei, X. Nie, Huiru Tang, Yulan Wang   +5 more
semanticscholar   +3 more sources

Mequindox resistance and in vitro efficacy in animal-derived Escherichia coli strains.

Veterinary Microbiology, 2015
This study investigated the in vitro efficacy of mequindox against enteropathogenic Escherichia coli (EPEC), and characterized the oqxAB genes as the main mequindox resistance determinant in E. coli strains of animal origin. A total of 1123 E.
Tao He, Yang Wang, M. Qian, Congming Wu
semanticscholar   +3 more sources

Acute and subchronic toxicological evaluation of Mequindox in Wistar rats.

Regulatory Toxicology and Pharmacology, 2010
We studied an acute and subchronic oral toxicity of Mequindox (MEQ), a quinoxaline 1,4-dioxide antimicrobial promoter, in Wistar rats according to OECD guidelines. For acute toxicity study, single doses of MEQ at 175, 550 and 2000 mg/kg b.w. were administered to rats by oral gavage. The calculated LD(50) was 550 mg/kg b.w.
Awais Ihsan, Xu Wang, Xianju Huang, Yu Liu, Qin Liu, Wen-Hu Zhou, Zonghui Yuan   +6 more
semanticscholar   +3 more sources

Identification of Eight in vivo Metabolites of Mequindox in Scophthalmus maximus by using UHPLC-MS/MS

Food Science and Human Wellness
Xin Mao, Yifang Hong, Xinru Li, Haoxian An, Shuang Zhou, Huihui Liu, Bin Qiu, Y. You   +7 more
semanticscholar   +2 more sources

Cytotoxicity of mequindox and its metabolites in HepG2 cells in vitro and murine hepatocytes in vivo.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2016
Mequindox, a quinoxaline 1,4-dioxide, is widely used as a feed additive in the Chinese livestock industry because of its effective antibacterial properties. Many recent studies have found that mequindox is rapidly metabolized to numerous metabolites following administration to animals.
Yingchun Liu, Wei Jiang, Yongjun Chen, Yanyan Y Liu, Peng Zeng, F. Xue, Quan Wang   +6 more
semanticscholar   +3 more sources

Pharmacokinetics of Mequindox and Its Metabolites in Swine

Agricultural Sciences in China, 2011
Abstract The present study was carried out to investigate the pharmacokinetics of mequindox (MEQ), a new synthetic quinoxaline 1,4-dioxide derivative and its two main metabolites M1 [2-isoethanol mequinoox], M2 [2-isoethanol 1-desoxymequindox] in healthy swine.
Yiming Liu, Yingchun Liu, H. Ding, B. Fang, Fan Yang, Q. Shan, Z. Zeng   +6 more
semanticscholar   +2 more sources

Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration.

Research in Veterinary Science, 2012
Pharmacokinetics of mequindox (MEQ) and its metabolites were determined in rats after intravenous (i.v.) and oral (p.o.) administration of MEQ at a single dose of 10 mg kg(-1) bodyweight. After both administrations, MEQ and five of its metabolites were quantified, except M4, whereas M1 and M2 were the predominant ones. The areas under the concentration-
Guanghu Li, Fan Yang, Limin He, H. Ding, N. Sun, Yingchun Liu, Yiming Liu, Q. Shan, Ya-fei Li, Z. Zeng   +9 more
semanticscholar   +3 more sources