Results 101 to 110 of about 267 (125)

Pharmacokinetics of Mequindox and Its Metabolites in Swine

Agricultural Sciences in China, 2011
Abstract The present study was carried out to investigate the pharmacokinetics of mequindox (MEQ), a new synthetic quinoxaline 1,4-dioxide derivative and its two main metabolites M1 [2-isoethanol mequinoox], M2 [2-isoethanol 1-desoxymequindox] in healthy swine.
Yi-ming LIU, Ying-chun LIU, Huan-zhong DING, Bing-hu FANG, Fan YANG, Qi SHAN, Zhen-ling ZENG   +6 more
openaire   +1 more source

Mequindox induces apoptosis, DNA damage, and carcinogenicity in Wistar rats

Food and Chemical Toxicology, 2019
Mequindox (MEQ) is a synthetic antibacterial agent. Recent studies showed that MEQ and its primary metabolites exhibit strong genotoxicity to mammalian cells, and MEQ induced carcinogenicity in mice. These findings suggest that chronic exposure to MEQ could lead to an increased risk of cancer later in life.
Qianying, Liu, Zhixin, Lei, Changqin, Gu, Jingchao, Guo, Huiru, Yu, Zainab, Fatima, Kaixiang, Zhou, Muhammad A B, Shabbir, Muhammad Kashif, Maan, Qinghua, Wu, Shuyu, Xie, Xu, Wang, Zonghui, Yuan   +12 more
openaire   +2 more sources

The Metabolism of Carbadox, Olaquindox, Mequindox, Quinocetone and Cyadox: An Overview

Medicinal Chemistry, 2013
The aim of this article is to get an overview of the metabolism of quinoxaline 1,4-di-N-oxides (QdNOs) used in food animals. The derivatives of QdNOs (carbadox, olaquindox, mequindox, quinocetone, and cyadox) are the potent synthetic antimicrobial agents that are used for improving the feed efficiency and controlling dysentery in food-producing animals.
Zhao-Ying, Liu, Zhi-Liang, Sun
openaire   +2 more sources

Solubility and dissolution thermodynamic properties of Mequindox in binary solvent mixtures

Journal of Molecular Liquids, 2020
Abstract The solubility of Mequindox(MEQ) in two kinds of binary mixtures(acetone+isopropanol; N-propanol+N-butanol) with different ratio was determined by shake flask method through UV–Vis spectrophotometer over the temperature from 293.15 to 323.15 K at atmospheric pressure(p = .1 MPa).
Shiqi Chen, Quanjin Liu, Haibo Dou, Li Zhang, Linlin Pei, Rouyue Huang, Gang Shu, Zhixiang Yuan, Juchun Lin, Wei Zhang, Guangneng Peng, Zhijun Zhong, Lizi Yin, Ling Zhao, Hualin Fu   +14 more
openaire   +1 more source

Dynamic changes in metabolic profiles of rats subchronically exposed to mequindox

Mol. BioSyst., 2014
Mequindox is widely used as an antibacterial veterinary drug and a feeding additive for farm animals in China. Although its toxicity has been widely studied, little is known regarding the metabolic effects of subchronic exposure to mequindox, which is vital for the health of meat producing livestock.
Limiao, Jiang, Xiuju, Zhao, Chongyang, Huang, Hehua, Lei, Huiru, Tang, Yulan, Wang   +5 more
openaire   +2 more sources

Mequindox resistance and in vitro efficacy in animal-derived Escherichia coli strains

Veterinary Microbiology, 2015
This study investigated the in vitro efficacy of mequindox against enteropathogenic Escherichia coli (EPEC), and characterized the oqxAB genes as the main mequindox resistance determinant in E. coli strains of animal origin. A total of 1123 E.
Tao, He, Yang, Wang, Minyi, Qian, Congming, Wu   +3 more
openaire   +2 more sources

Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol and Cloned Carbonyl Reductase 1

Drug Metabolism and Disposition, 2012
Mequindox (MEQ) is a novel synthetic quinoxaline 1,4-dioxides derivative, which is widely used as a veterinary drug and animal feed additive. However, the metabolic mechanism of MEQ is rarely reported. The N-oxide reduction mechanism of MEQ was reported in our previous work.
Xianqing, Tang, Peiqiang, Mu, Jun, Wu, Jun, Jiang, Caihui, Zhang, Ming, Zheng, Yiqun, Deng   +6 more
openaire   +2 more sources

Spectroscopic Studies on the Binding of Bacteriophage Mequindox with Bovine Serum Albumin

Chinese Journal of Chemistry, 2009
AbstractFluorescence spectra and UV‐Vis absorption spectra have been used to study the binding of bacteriophage mequindox (MEQ) with bovine serum albumin (BSA), which performed a dynamic quenching process. The quenching constants and thermodynamic parameters at different temperatures were calculated.
Zhouhua ZENG, Yi LIU, Xianming HU, Zhenqiang XU, Kun ZENG   +4 more
openaire   +1 more source

Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration

Research in Veterinary Science, 2012
Pharmacokinetics of mequindox (MEQ) and its metabolites were determined in rats after intravenous (i.v.) and oral (p.o.) administration of MEQ at a single dose of 10 mg kg(-1) bodyweight. After both administrations, MEQ and five of its metabolites were quantified, except M4, whereas M1 and M2 were the predominant ones. The areas under the concentration-
Guanghui, Li, Fan, Yang, Limin, He, Huanzhong, Ding, Na, Sun, Yingchun, Liu, Yiming, Liu, Qi, Shan, Yafei, Li, Zhenling, Zeng   +9 more
openaire   +2 more sources

Comparative Metabolism of Mequindox in Liver Microsomes, Hepatocytes, and Intestinal Microflora of Chicken

Analytical Letters, 2012
Drug metabolism studies in vitro were carried out inexpensively and readily to serve as an adequate mechanism to characterize drug metabolites, elucidate their pathways, and make suggestions for further testing in vivo. In this work, the comparative metabolism of mequindox (MEQ) was investigated in vitro by incubation with chicken liver microsomes ...
Yan Li, Linxia Li, Jianzhong Shen, Suxia Zhang, Peisheng Feng, Haixia Wu, Congming Wu   +6 more
openaire   +1 more source