Results 111 to 120 of about 267 (125)

Metabolism of mequindox and its metabolites identification in chickens using LC–LTQ-Orbitrap mass spectrometry

Journal of Chromatography B, 2012
Mequindox (MEQ), 3-methyl-2-quinoxalinacetyl-1,4-dioxide, is widely used in Chinese veterinary medicine as an antimicrobial and feed additive. Its toxicities have been reported to be closely related to its metabolism. To understand more clearly the metabolic pathways of MEQ, its metabolism in chickens was studied using liquid chromatography coupled ...
Qi, Shan, Yiming, Liu, Limin, He, Huanzhong, Ding, Xianhui, Huang, Fan, Yang, Yafei, Li, Zhenling, Zeng   +7 more
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Cytotoxicity of mequindox and its metabolites in HepG2 cells in vitro and murine hepatocytes in vivo

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2016
Mequindox, a quinoxaline 1,4-dioxide, is widely used as a feed additive in the Chinese livestock industry because of its effective antibacterial properties. Many recent studies have found that mequindox is rapidly metabolized to numerous metabolites following administration to animals.
Yingchun, Liu, Wei, Jiang, Yongjun, Chen, Yanyan, Liu, Peng, Zeng, Feiqun, Xue, Quan, Wang   +6 more
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Analysis of mequindox and its two metabolites in swine liver by UPLC-MS/MS

Analytical Methods, 2012
A new ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed for the determination of mequindox (MEQ) and its two metabolites (1-desoxymequindox and 1, 4-bisdesoxymequindox, 1-DMEQ and BDMEQ) in swine liver. This method was validated on the basis of Commission Decision 2002/657/EC.
Kaili Liu, Xingyuan Cao, Zhanhui Wang, Linxia Li, Jianzhong Shen, Linli Cheng, Suxia Zhang   +6 more
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Long-term mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats

Toxicology and Applied Pharmacology, 2011
Mequindox (MEQ) is a synthetic antimicrobial chemical of quinoxaline 1, 4-dioxide group. This study was designed to investigate the hypothesis that MEQ exerts testicular toxicity by causing oxidative stress and steroidal gene expression profiles and determine mechanism of MEQ testicular toxicity.
Awais, Ihsan, Xu, Wang, Zhaoying, Liu, Yulian, Wang, Xianju, Huang, Yu, Liu, Huan, Yu, Hongfei, Zhang, Tingting, Li, Chunhui, Yang, Zonghui, Yuan   +10 more
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Pharmacokinetics of mequindox and one of its major metabolites in chickens after intravenous, intramuscular and oral administration

Research in Veterinary Science, 2012
Pharmacokinetics of mequindox and one of its major metabolites (M) was determined in chickens after intravenous (i.v.), intramuscular (i.m.) and oral administration of mequindox at a single dose of 10 (i.v. and i.m.) or 20 mg/kg b.w. (oral). Plasma concentration profiles were analyzed by a non-compartmental pharmacokinetic method.
Huanzhong, Ding, Yingchun, Liu, Zhenling, Zeng, Hongbin, Si, Kaiyong, Liu, Yiming, Liu, Fan, Yang, Yafei, Li, Dongping, Zeng   +8 more
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Liquid chromatography tandem mass spectrometry for the simultaneous determination of mequindox and its metabolites in porcine tissues

Journal of Separation Science, 2012
A rapid liquid chromatography tandem mass spectrometric method was developed for the simultaneous determination of mequindox and its five metabolites (2‐isoethanol mequindox, 2‐isoethanol 1‐desoxymequindox, 1‐desoxymequindox, 1,4‐bisdesoxymequindox, and 2‐isoethanol bisdesoxymequindox) in porcine muscle, liver, and kidney, fulfilling confirmation ...
Dongping, Zeng, Xiangguang, Shen, Limin, He, Huanzhong, Ding, Youzhi, Tang, Yongxue, Sun, Binghu, Fang, Zhenling, Zeng   +7 more
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Simultaneous determination of mequindox, quinocetone, and their major metabolites in chicken and pork by UPLC–MS/MS

Food Chemistry, 2014
This report presents a UPLC-MS/MS method for determination of mequindox (MEQ), quinocetone (QCT) and their 11 metabolites in chicken and pork samples. Following extraction process with acetonitrile-ethyl acetate, acidulation, and re-extraction with ethyl acetate in turn, target analytes were further purified using C18 solid phase extraction (SPE ...
Yanshen, Li, Kaili, Liu, Ross C, Beier, Xingyuan, Cao, Jianzhong, Shen, Suxia, Zhang   +5 more
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Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox

Toxicology, 2011
Mequindox (MEQ) is a novel synthetic quinoxaline 1,4-dioxides antibacterial agent and growth promoter in animal husbandry. This study was to investigate whether reactive oxygen species (ROS), the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway, suppressors of cytokine signaling (SOCS) and inflammatory cytokines were ...
Xu, Wang, Xian-Ju, Huang, Awais, Ihsan, Zhao-Ying, Liu, Ling-Li, Huang, Hua-Hai, Zhang, Hong-Fei, Zhang, Wen, Zhou, Qin, Liu, Xi-Juan, Xue, Zong-Hui, Yuan   +10 more
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Interactions of NADPH oxidase, renin–angiotensin–aldosterone system and reactive oxygen species in mequindox-mediated aldosterone secretion in Wistar rats

Toxicology Letters, 2010
High doses of mequindox (MEQ) are associated with oxidative stress and pathological toxicity in the kidney. In this study, we demonstrated long term effects of MEQ on intra- or extra-adrenal renin-angiotensin-aldosterone system (RAAS) in vivo. RAAS plays a major role in aldosterone secretion.
Xian-Ju, Huang, Xu, Wang, Awais, Ihsan, Qin, Liu, Xi-Juan, Xue, Shi-Jia, Su, Chun-Hui, Yang, Wen, Zhou, Zong-Hui, Yuan   +8 more
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The structure elucidation of mequindox and 1,4-bisdesoxymequindox: NMR analyses, FT-IR spectra, DFT calculations and thermochemical studies

Journal of Molecular Structure, 2011
In the current work, we report a combined experimental and theoretical study on the molecular conformation, vibrational spectra, and nuclear magnetic resonance (NMR) spectra of mequindox (MEQ) and 1,4-bisdesoxymequindox (1,4-BDM). The geometric structure and vibrational frequencies of MEQ and 1,4-BDM have been calculated by density functional theory ...
Jiaheng Zhang, Xin He, Haixiang Gao
openaire   +1 more source