Results 111 to 120 of about 403 (128)

Simultaneous determination of mequindox, quinocetone, and their major metabolites in chicken and pork by UPLC-MS/MS.

Food Chemistry, 2014
This report presents a UPLC-MS/MS method for determination of mequindox (MEQ), quinocetone (QCT) and their 11 metabolites in chicken and pork samples. Following extraction process with acetonitrile-ethyl acetate, acidulation, and re-extraction with ethyl acetate in turn, target analytes were further purified using C18 solid phase extraction (SPE ...
Yanshen Li, Kaili Liu, R. Beier, Xingyuan Cao, Jianzhong Shen, Suxia Zhang   +5 more
semanticscholar   +3 more sources

Metabolism of mequindox and its metabolites identification in chickens using LC-LTQ-Orbitrap mass spectrometry.

Journal of Chromatography B, 2012
Mequindox (MEQ), 3-methyl-2-quinoxalinacetyl-1,4-dioxide, is widely used in Chinese veterinary medicine as an antimicrobial and feed additive. Its toxicities have been reported to be closely related to its metabolism. To understand more clearly the metabolic pathways of MEQ, its metabolism in chickens was studied using liquid chromatography coupled ...
Q. Shan, Yiming Liu, Limin He, H. Ding, Xianhui Huang, Fan Yang, Ya-fei Li, Z. Zeng   +7 more
semanticscholar   +3 more sources

Pharmacokinetics of mequindox and one of its major metabolites in chickens after intravenous, intramuscular and oral administration.

Research in Veterinary Science, 2012
Pharmacokinetics of mequindox and one of its major metabolites (M) was determined in chickens after intravenous (i.v.), intramuscular (i.m.) and oral administration of mequindox at a single dose of 10 (i.v. and i.m.) or 20 mg/kg b.w. (oral). Plasma concentration profiles were analyzed by a non-compartmental pharmacokinetic method.
H. Ding, Yingchun Liu, Z. Zeng, Hongbin Si, Kaiyong Liu, Yiming Liu, Fan Yang, Ya-fei Li, D. Zeng   +8 more
semanticscholar   +3 more sources

Simple and Fast Extraction-Coupled UPLC-MS/MS Method for the Determination of Mequindox and Its Major Metabolites in Food Animal Tissues.

Journal of Agricultural and Food Chemistry, 2016
This research described a sensitive and rapid UPLC-MS/MS method for the determination of mequindox and its six major metabolites in chicken muscle, chicken liver, swine muscle, and swine liver. Among the metabolites, carbonyl reduction-1,4-bisdesoxy-mequindox is novel.
Y. You, Liting Song, Yanshen Li, Yongtao Wu, Mao Xin   +4 more
semanticscholar   +3 more sources

Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol and Cloned Carbonyl Reductase 1

Drug Metabolism and Disposition, 2012
Mequindox (MEQ) is a novel synthetic quinoxaline 1,4-dioxides derivative, which is widely used as a veterinary drug and animal feed additive. However, the metabolic mechanism of MEQ is rarely reported. The N-oxide reduction mechanism of MEQ was reported in our previous work.
Xianqing Tang, Peiqiang Mu, Jun Wu, Jun Jiang, Caihui Zhang, M. Zheng, Yiqun Deng   +6 more
semanticscholar   +3 more sources

Long-term mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats.

Toxicology and Applied Pharmacology, 2011
Mequindox (MEQ) is a synthetic antimicrobial chemical of quinoxaline 1, 4-dioxide group. This study was designed to investigate the hypothesis that MEQ exerts testicular toxicity by causing oxidative stress and steroidal gene expression profiles and determine mechanism of MEQ testicular toxicity.
Awais Ihsan, Xu Wang, Zhaoying Liu, Yulian Wang, Xianju Huang, Yu Liu, Huan Yu, Hongfei Zhang, Tingting Li, Chu-Chun Yang, Zonghui Yuan   +10 more
semanticscholar   +3 more sources

Liquid chromatography tandem mass spectrometry for the simultaneous determination of mequindox and its metabolites in porcine tissues.

Journal of Separation Science, 2012
A rapid liquid chromatography tandem mass spectrometric method was developed for the simultaneous determination of mequindox and its five metabolites (2‐isoethanol mequindox, 2‐isoethanol 1‐desoxymequindox, 1‐desoxymequindox, 1,4‐bisdesoxymequindox, and 2‐isoethanol bisdesoxymequindox) in porcine muscle, liver, and kidney, fulfilling confirmation ...
D. Zeng, Xiangguang Shen, Limin He, H. Ding, Youzhi Tang, Yongxue Sun, B. Fang, Z. Zeng   +7 more
semanticscholar   +3 more sources

Metabolites and JAK/STAT pathway were involved in the liver and spleen damage in male Wistar rats fed with mequindox.

Toxicology, 2011
Mequindox (MEQ) is a novel synthetic quinoxaline 1,4-dioxides antibacterial agent and growth promoter in animal husbandry. This study was to investigate whether reactive oxygen species (ROS), the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway, suppressors of cytokine signaling (SOCS) and inflammatory cytokines were ...
Xu Wang, Xianju Huang, Awais Ihsan, Zhaoying Liu, Ling-Li Huang, Hua-Hai Zhang, Hong-Fei Zhang, Wen-Hu Zhou, Qin Liu, Xijuan Xue, Zonghui Yuan   +10 more
semanticscholar   +3 more sources

Analysis of mequindox and its two metabolites in swine liver by UPLC-MS/MS

Analytical Methods, 2012
A new ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed for the determination of mequindox (MEQ) and its two metabolites (1-desoxymequindox and 1, 4-bisdesoxymequindox, 1-DMEQ and BDMEQ) in swine liver. This method was validated on the basis of Commission Decision 2002/657/EC.
Kaili Liu, Xingyuan Cao, Zhanhui Wang, Linxia Li, Jianzhong Shen, Linli Cheng, Suxia Zhang   +6 more
semanticscholar   +2 more sources

Simultaneous determination of four synthesized metabolites of mequindox in urine samples using ultrasound-assisted dispersive liquid-liquid microextraction combined with high-performance liquid chromatography.

Talanta, 2012
A novel pretreatment method termed ultrasound-assisted dispersive liquid-liquid microextraction (UADLLME) coupled with high-performance liquid chromatography-ultraviolet detector (HPLC-UV) was applied for the detection of four synthesized metabolites of mequindox in pig urine samples. A total volume of 200 μL of methanol (dispersant) and 60 μL of 1,1,2,
Jiaheng Zhang, Haixiang Gao, Bing Peng, Yubo Li, Songqing Li, Zhiqiang Zhou   +5 more
semanticscholar   +3 more sources