Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System [PDF]
, 2012 NADPH-cytochrome P450 oxidoreductase (CYPOR) variants have been described in patients with perturbed steroidogenesis and sexual differentiation, related to Antley-Bixler syndrome (ABS). It is important to determine the effect of these variants on CYP3A4,
Bettie Sue Masters +5 more
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Toxic metabolites, Sertoli cells and Y chromosome related genes are potentially linked to the reproductive toxicity induced by mequindox. [PDF]
Oncotarget, 2017 Mequindox (MEQ) is a relatively new synthetic antibacterial agent widely applied in China since the 1980s. However, its reproductive toxicity has not been adequately performed. In the present study, four groups of male Kunming mice (10 mice/group) were fed diets containing MEQ (0, 25, 55 and 110 mg/kg in the diet) for up to 18 months.
Liu Q, Lei Z, Dai M, Wang X, Yuan Z.
europepmc +4 more sources
МИКРОЭКСТРАКЦИОННОЕ КОНЦЕНТРИРОВАНИЕ ПРИМЕСЕЙ ИЗ ВОДЫ С УЛЬТРАЗВУКОВЫМ ДИСПЕРГИРОВАНИЕМ ЭКСТРАГЕНТА [PDF]
, 2014 Microextraction preconcentration of impurities with ultrasonic dispersion of extractant exceeds in efficiency drop microextraction and microextraction with dispersion on auxiliary component.
Krylov, V. A. +2 more
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In vitro antioxidant activities of resveratrol, cinnamaldehyde and their synergistic effect against cyadox-induced cytotoxicity in rabbit erythrocytes [PDF]
, 2017 This study was conducted to explore the potential benefits of using cinnamaldehyde (CIN), resveratrol (RES) separately or in combination on cyadox (CYA)-induced alterations in isolated rabbit erythrocytes. Erythrocytes suspensions were partitioned into 7
Alagawany, Mahmoud +2 more
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N-Oxide Reduction of Quinoxaline-1,4-Dioxides Catalyzed by [PDF]
, 2020 Quinoxaline-1,4-dioxides (QdNOs) are a class of quinoxaline derivatives that are widely used in humans or animals as drugs or feed additives. However, the metabolic mechanism, especially the involved enzymes, has not been reported in detail.
Kaixin Wu +11 more
core
, 2021 Research and development in animal husbandry and products manufacturing are ongoing, and the results should be summarized from time to time and made available to the reader in order to increase their knowledge.The present publication seeks to present the
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Physiologically based kinetic models for farm animals: Critical review of published models and future perspectives for their use in chemical risk assessment [PDF]
, 2019 Physiologically based kinetic (PBK) models in the 10 most common species of farm animals were identified through an extensive literature search. This resulted in 39 PBK models, mostly for pharmaceuticals. The models were critically assessed using the WHO
Dorne, J.L. +3 more
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Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox. [PDF]
Sci Rep, 2017 AbstractMequindox (MEQ) is a synthetic antimicrobial agent of quinoxaline-1,4-dioxide group (QdNOs). The liver is regarded as the toxicity target of QdNOs, and the role of N → O group-associated various toxicities mediated by QdNOs is well recognized. However, the mechanism underlying the in vivo effects of MEQ on the liver, and whether the metabolic ...
Liu Q +8 more
europepmc +4 more sources
Obesity and cage environment modulate metabolism in the Zucker rat: a multiple biological matrix approach to characterizing metabolic phenomena [PDF]
, 2019 Obesity and its comorbidities are increasing worldwide imposing a heavy socioeconomic burden. The effects of obesity on the metabolic profiles of tissues (liver, kidney, pancreas), urine, and the systemic circulation were investigated in the Zucker rat ...
Holmes, E +5 more
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INVESTIGATING INTERCELLULAR SIGNALING BETWEEN THE ALVEOLAR EPITHELIUM AND MICROVASCULAR ENDOTHELIUM WITH AN ORGANOTYPIC MODEL OF THE ALVEOLAR CAPILLARY REGION [PDF]
, 2022 The alveolar capillary region (ACR) of the lung is a large, susceptible target of inhaled materials. As the interface of the respiratory and cardiovascular region, deposited material in the ACR induces adverse respiratory and cardiovascular effects ...
Vitucci, Eva
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