Unique Pharmacokinetic and Pharmacodynamic Parameters of Antimicrobials in Goats [PDF]
, 2019 Pharmacokinetics, the process that involves drug absorption, distribution, metabolism and excretion (ADME) of antimicrobials, determines pharmacodynamic response, that is, what drugs do to the body.
Saganuwan, Saganuwan Alhaji
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Baseline and time-updated factors in preclinical development of anionic dendrimers as successful anti-HIV-1 vaginal microbicides [PDF]
, 2022 Although a wide variety of topical microbicides provide promising in vitro and in vivo efficacy, most of them failed to prevent sexual transmission of human immunodeficiency virus type 1 (HIV-1) in human clinical trials.
Lasso, Jose María +4 more
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Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part II - Polysaccharides and Proteins [PDF]
, 2021 Encapsulation remains a fundamental and consistent approach of fabrication of drug and diagnostic delivery systems in the health space and natural polymers such as polysaccharides and proteins continue to play significant roles.
Abu Elella, Mahmoud H. +8 more
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Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System [PDF]
, 2012 NADPH-cytochrome P450 oxidoreductase (CYPOR) variants have been described in patients with perturbed steroidogenesis and sexual differentiation, related to Antley-Bixler syndrome (ABS). It is important to determine the effect of these variants on CYP3A4,
Bettie Sue Masters +5 more
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МИКРОЭКСТРАКЦИОННОЕ КОНЦЕНТРИРОВАНИЕ ПРИМЕСЕЙ ИЗ ВОДЫ С УЛЬТРАЗВУКОВЫМ ДИСПЕРГИРОВАНИЕМ ЭКСТРАГЕНТА [PDF]
, 2014 Microextraction preconcentration of impurities with ultrasonic dispersion of extractant exceeds in efficiency drop microextraction and microextraction with dispersion on auxiliary component.
Krylov, V. A. +2 more
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In vitro antioxidant activities of resveratrol, cinnamaldehyde and their synergistic effect against cyadox-induced cytotoxicity in rabbit erythrocytes [PDF]
, 2017 This study was conducted to explore the potential benefits of using cinnamaldehyde (CIN), resveratrol (RES) separately or in combination on cyadox (CYA)-induced alterations in isolated rabbit erythrocytes. Erythrocytes suspensions were partitioned into 7
Alagawany, Mahmoud +2 more
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, 2021 Research and development in animal husbandry and products manufacturing are ongoing, and the results should be summarized from time to time and made available to the reader in order to increase their knowledge.The present publication seeks to present the
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N-Oxide Reduction of Quinoxaline-1,4-Dioxides Catalyzed by [PDF]
, 2020 Quinoxaline-1,4-dioxides (QdNOs) are a class of quinoxaline derivatives that are widely used in humans or animals as drugs or feed additives. However, the metabolic mechanism, especially the involved enzymes, has not been reported in detail.
Kaixin Wu +11 more
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Physiologically based kinetic models for farm animals: Critical review of published models and future perspectives for their use in chemical risk assessment [PDF]
, 2019 Physiologically based kinetic (PBK) models in the 10 most common species of farm animals were identified through an extensive literature search. This resulted in 39 PBK models, mostly for pharmaceuticals. The models were critically assessed using the WHO
Dorne, J.L. +3 more
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Obesity and cage environment modulate metabolism in the Zucker rat: a multiple biological matrix approach to characterizing metabolic phenomena [PDF]
, 2019 Obesity and its comorbidities are increasing worldwide imposing a heavy socioeconomic burden. The effects of obesity on the metabolic profiles of tissues (liver, kidney, pancreas), urine, and the systemic circulation were investigated in the Zucker rat ...
Holmes, E +5 more
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