Results 81 to 90 of about 89,290 (238)

Regulation of drug resistance and virulence of Acinetobacter baumannii by quorum sensing system under antibiotic pressure

Frontiers in Microbiology
IntroductionAcinetobacter baumannii is a formidable pathogen renowned for its role in hospital-acquired infections. In recent years, largely due to antibiotic abuse and other reasons, bacteria are frequently exposed to sub-minimum inhibitory ...
Xingyu Jiang, Xuchun Shan, Xiaomeng Yang, Xin Zhang, Yang Xiang, Yan Chen, Zhaohui Ni   +6 more
doaj   +1 more source

Effects of post‐hepatic portoenterostomy adjuvant therapy on liver transplantation in children with biliary atresia: A systematic review

JPGN Reports, EarlyView.
Abstract Objectives Biliary atresia (BA) is a cholangiopathy characterized by obstruction of the intrahepatic and extrahepatic bile ducts. Hepatic portoenterostomy (HPE) is the primary palliative treatment and there is still an urgent need to improve post‐HPE management.
Bianca Ferraz de Almeida Silva, Alice Palmeira Nascimento Cerqueira, Breno Oliveira Marques, Gabriela Garcia de Carvalho Laguna, Gabrielle dos Santos Aguiar, Luana Leal Gonzaga, Raquel Teles de Lacerda, Natalia Oliveira e Silva   +7 more
wiley   +1 more source

IGNITE4: Results of a Phase 3, Randomized, Multicenter, Prospective Trial of Eravacycline vs Meropenem in the Treatment of Complicated Intraabdominal Infections

Clinical Infectious Diseases, 2018
Background Increasing antimicrobial resistance among pathogens that cause complicated intraabdominal infections (cIAIs) supports the development of new antimicrobials.
J. Solomkin, J. Gardovskis, K. Lawrence, P. Montravers, Angie Sway, David C. Evans, L. Tsai   +6 more
semanticscholar   +1 more source

Independent Risk Factors for Postoperative Intestinal Obstruction and Clinical Outcomes in Simultaneous Pancreas‐Kidney Transplantation Recipients

Organ Medicine, EarlyView.
Intestinal obstruction (IO) is an important but underexplored complication following simultaneous pancreas‐kidney transplantation (SPKT) and is associated with considerable morbidity and both clinical and economic burdens. In this single‐center cohort study, perioperative parameters, including demographic characteristics, surgical variables, and ...
Rongxin Chen, Zebin Guo, Guanghui Li, Jiali Fang, Jialin Wu, Zhuangqiang Fang, Luhao Liu, Zheng Chen   +7 more
wiley   +1 more source

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Carbapenems as Antidotes for the Management of Acute Valproic Acid Poisoning

Pharmaceuticals
Introduction: Valproic acid (VPA) is a broad-spectrum drug primarily used in the treatment of epilepsy and bipolar disorder. It is not an uncommon occurrence for VPA to cause intoxication.
Nataša Perković Vukčević, Vesna Mijatović Jovin, Gordana Vuković Ercegović, Marko Antunović, Igor Kelečević, Dejan Živanović, Slavica Vučinić   +6 more
doaj   +1 more source

Isolation of carbapenem‐resistant Pseudomonas aeruginosa and other Gram‐negative ESKAPE organisms from samples of raw‐meat diets for dogs in the UK

Veterinary Record, EarlyView.
Abstract Background Gram‐negative ESKAPE organisms are an emerging threat in veterinary medicine that also have zoonotic potential. However, little is known about the prevalence and risks of these organisms in pet food. We present the incidental finding of gram‐negative ESKAPE organisms within samples of raw meat diets for dogs in the United Kingdom ...
Genever Morgan, Nicola Williams, Jenny Llewelyn, Sam Haldenby, Gina Pinchbeck, Dorina Timofte   +5 more
wiley   +1 more source

Clinical Features and Outcomes of Chronic Otitis Media Complications: A 20‐Year Retrospective Study at a Tertiary Hospital

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Chronic otitis media (COM) is a major public health concern, particularly in developing countries. Although complications have decreased with modern antibiotics, they still cause significant morbidity and mortality. This study analyzed the clinical features, bacteriological profiles, and treatment outcomes of COM complications at a ...
Viraporn Atchariyasathian, Nipit Tangchitnob   +1 more
wiley   +1 more source

Plan of action for carbapenem antibiotics sterility testing

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article proposes a plan of action for assessing effectiveness and reliability of sterility testing in terms of neutralization of antimicrobial activity of residual amounts of antibiotics remaining on the membrane filters during the analysis.
S. I. Kuleshova, S. A. Protsak, S. A. Lisunova, G. Yu. Romanyuk, E. N. Semenova   +4 more
doaj  

Optimization of meropenem dosing regimens in critically ill patients with augmented renal clearance

Frontiers in Medicine
The pharmacokinetics of meropenem are significantly altered in patients with augmented renal clearance (ARC), resulting in suboptimal plasma concentrations.
Jinfeng Luo, Jing Liu, Hongfu Lin, Yang Yang, Caihong Chen, Jianping Chen, Han Zhong, Shipao Zhang   +7 more
doaj   +1 more source