Results 61 to 70 of about 78,101 (219)

Pediatric Clostridiodes difficile infection with toxic megacolon successfully treated with fecal microbiota transplantation

JPGN Reports, EarlyView.
Abstract The rising incidence of pediatric Clostridioides difficile infection (CDI), particularly in medically complex patients, calls for novel, individualized treatments. While fecal microbiota transplantation (FMT) is well‐described for recurrent CDI, this report describes the first pediatric case of fulminant CDI with toxic megacolon successfully ...
Dana McCarney, Pamela Chen, Jenna Simes, Stacy A. Kahn   +3 more
wiley   +1 more source

Antimicrobial Susceptibility Pattern of Extended-Spectrum Beta-Lactamase Producing Escherichia coli in Urinary Tract Infection [PDF]

Journal of Sharif Medical & Dental College
Objective: To detect the frequency of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli in urinary tract infection and also determine their antibiotic susceptibility to various antimicrobials.
Tariq Hussain, Abeer Zafar, Rizwan Ahmad, Hassan Atique, Muaz Mubashir, Mehdi Naqvi   +5 more
doaj  

Regulation of drug resistance and virulence of Acinetobacter baumannii by quorum sensing system under antibiotic pressure

Frontiers in Microbiology
IntroductionAcinetobacter baumannii is a formidable pathogen renowned for its role in hospital-acquired infections. In recent years, largely due to antibiotic abuse and other reasons, bacteria are frequently exposed to sub-minimum inhibitory ...
Xingyu Jiang, Xuchun Shan, Xiaomeng Yang, Xin Zhang, Yang Xiang, Yan Chen, Zhaohui Ni   +6 more
doaj   +1 more source

Genetic and phenotypic of Pseudomonas aeruginosa sensitive to meropenem antibiotics after exposure to meropenem [PDF]

Background and Objectives: Pseudomonas aeruginosa, drug-resistant, causes health infections. Resistance to the preferred therapy meropenem is a serious threat.
Asmarinah Asmarinah, Agus Evendi, Fera Ibrahim, Anis Karuniawati   +3 more
core   +1 more source

Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Meropenem in Neurocritical Care Patients: a Prospective Two-Center Study

, 2022
Morbidity and mortality related to ventriculitis in neurocritical care patients remain high. Antibiotic dose optimization may improve therapeutic outcomes. In this study, a population pharmacokinetic model of meropenem in infected critically ill patients
Joynt, Gavin M., Wong, Wai Tat, Roberts, Jason A, Cotta, Menino Osbert, Joynt, Gavin M, Heffernan, Aaron J, Livermore, Amelia, Heffernan, Aaron J., Starr, Therese, Lipman, Jeffrey, Kumta, Nilesh, Wallis, Steven C, Wallis, Steven C., Roberts, Jason A.   +13 more
core   +1 more source

Effects of post‐hepatic portoenterostomy adjuvant therapy on liver transplantation in children with biliary atresia: A systematic review

JPGN Reports, EarlyView.
Abstract Objectives Biliary atresia (BA) is a cholangiopathy characterized by obstruction of the intrahepatic and extrahepatic bile ducts. Hepatic portoenterostomy (HPE) is the primary palliative treatment and there is still an urgent need to improve post‐HPE management.
Bianca Ferraz de Almeida Silva, Alice Palmeira Nascimento Cerqueira, Breno Oliveira Marques, Gabriela Garcia de Carvalho Laguna, Gabrielle dos Santos Aguiar, Luana Leal Gonzaga, Raquel Teles de Lacerda, Natalia Oliveira e Silva   +7 more
wiley   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Meropenem-RPX7009 Concentrations in Plasma, Epithelial Lining Fluid, and Alveolar Macrophages of Healthy Adult Subjects.

, 2016
The steady-state concentrations of meropenem and the β-lactamase inhibitor RPX7009 in plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations were obtained in 25 healthy, nonsmoking adult subjects.
S Durso (7942547), KA Rodvold (7942556), JS Loutit (7942544), E Wenzler (7942538), MH Gotfried (7942541), DC Griffith (7942550), MN Dudley (7942553)   +6 more
core  

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Carbapenems as Antidotes for the Management of Acute Valproic Acid Poisoning

Pharmaceuticals
Introduction: Valproic acid (VPA) is a broad-spectrum drug primarily used in the treatment of epilepsy and bipolar disorder. It is not an uncommon occurrence for VPA to cause intoxication.
Nataša Perković Vukčević, Vesna Mijatović Jovin, Gordana Vuković Ercegović, Marko Antunović, Igor Kelečević, Dejan Živanović, Slavica Vučinić   +6 more
doaj   +1 more source