Results 51 to 60 of about 89,290 (238)

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application

Frontiers in Pharmacology
Background and purposeTherapeutic Drug Monitoring (TDM) is advocated to optimize antibiotic therapy, yet its efficacy remains debated. This systematic review and meta-analysis evaluates TDM’s impact on meropenem therapy, focusing on treatment efficacy ...
Yi-Chang Zhao, Yi-Chang Zhao, Jia-Yi Liu, Jia-Yi Liu, Jia-Kai Li, Jia-Kai Li, Huai-Yuan Liu, Huai-Yuan Liu, Zhi-Hua Sun, Zhi-Hua Sun, Bi-Kui Zhang, Bi-Kui Zhang, Miao Yan, Miao Yan   +13 more
doaj   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Activity of meropenem/vaborbactam and comparators against Gram-negative isolates from Eastern and Western European patients hospitalized with pneumonia including ventilator-associated pneumonia (2014–19)

Journal of Antimicrobial Chemotherapy, 2021
Objectives Meropenem/vaborbactam has been approved in Europe for the treatment of hospital-acquired bacterial pneumonia, ventilator-associated pneumonia (VAP) and bacteraemia among other indications.
D. Shortridge, C. Carvalhaes, L. Deshpande, M. Castanheira   +3 more
semanticscholar   +1 more source

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

ACINETOBACTER BAUMANNII: PREVALENCE, SPECTRUM AND DYNAMICS OF ANTIMICROBIAL RESISTANCE, SUSCEPTIBILITY TO ANTIBIOTIC COMBINATIONS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
Objective. To study the spectrum and dynamics of antimicrobial resistance to Acinetobacter baumannii, to assess the resistance mechanisms to carbapenems and antibiotic combinations susceptibility. Material and Methods.
Tapalski D. V., Bonda N. A.
doaj   +1 more source

Relationship between continuous infusion meropenem PK/PD target attainment and C‐reactive protein dynamics in onco‐haematologic patients with febrile neutropenia

British Journal of Clinical Pharmacology, EarlyView.
Aim Meropenem is a second‐line antimicrobial agent in the treatment of febrile neutropenia in onco‐haematological patients. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between meropenem exposure and C‐reactive protein (C‐RP) over time was conducted.
Chun Liu, Pier Giorgio Cojutti, J. G. Coen van Hasselt, Michele Bartoletti, Maddalena Giannella, Pierluigi Zinzani, Pierluigi Viale, Federico Pea   +7 more
wiley   +1 more source

Synergistic effect and antibiofilm activity of the antimicrobial peptide K11 with conventional antibiotics against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionInfections caused by drug-resistant Klebsiella pneumoniae are now a serious problem for public health, associated with high morbidity and mortality due to limited treatment options.
Chawalit Chatupheeraphat, Jiratchaya Peamchai, Sirirat Luk-in, Warawan Eiamphungporn   +3 more
doaj   +1 more source

Synergistic Antibacterial Effects of Meropenem in Combination with Aminoglycosides against Carbapenem-Resistant Escherichia coli Harboring blaNDM-1 and blaNDM-5

Antibiotics, 2021
Infections due to carbapenem-resistant Escherichia coli (CREC) are problematic due to limitation in treatment options. Combination therapies of existing antimicrobial agents have become a reliable strategy to control these infections.
Pawarisa Terbtothakun, O. Nwabor, Thanyaluck Siriyong, S. Voravuthikunchai, Saranyu Chusri   +4 more
semanticscholar   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source