Results 31 to 40 of about 78,101 (219)

Emergence of Carbapenem Resistant Non-Fermenting Gram-Negative Bacilli Isolated in an Icu of a Tertiary Care Hospital [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: The emergence and spread of Multi-Drug Resistant (MDR) Non-Fermenting Gram-Negative Bacilli (NFGNB) in Intensive Care Units (ICU) and their genetic potential to transmit diverse antibiotic resistance regardless of their ability to ...
Sonika Agarwal, Barnali Kakati, Sushant Khanduri, Shalini Gupta   +3 more
doaj   +1 more source

Construction and validation of a meropenem-induced liver injury risk prediction model: a multicenter case-control study

Frontiers in Pharmacology
ObjectiveTo construct and validate a risk prediction model for patients with meropenem-induced liver injury (MiLI).MethodsA retrospective case-control study was conducted to collect data on inpatients treated with meropenem at Shiyan People’s Hospital ...
Yan He, Yan He, Hongqin Ke, Jianyong Zhu, Xin Yuan, Hongliang Li, Hongliang Li, Wenwen Wu, Shuman Yang, Shuman Yang, Huibin Yu, Huibin Yu   +11 more
doaj   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application

Frontiers in Pharmacology
Background and purposeTherapeutic Drug Monitoring (TDM) is advocated to optimize antibiotic therapy, yet its efficacy remains debated. This systematic review and meta-analysis evaluates TDM’s impact on meropenem therapy, focusing on treatment efficacy ...
Yi-Chang Zhao, Yi-Chang Zhao, Jia-Yi Liu, Jia-Yi Liu, Jia-Kai Li, Jia-Kai Li, Huai-Yuan Liu, Huai-Yuan Liu, Zhi-Hua Sun, Zhi-Hua Sun, Bi-Kui Zhang, Bi-Kui Zhang, Miao Yan, Miao Yan   +13 more
doaj   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

ACINETOBACTER BAUMANNII: PREVALENCE, SPECTRUM AND DYNAMICS OF ANTIMICROBIAL RESISTANCE, SUSCEPTIBILITY TO ANTIBIOTIC COMBINATIONS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
Objective. To study the spectrum and dynamics of antimicrobial resistance to Acinetobacter baumannii, to assess the resistance mechanisms to carbapenems and antibiotic combinations susceptibility. Material and Methods.
Tapalski D. V., Bonda N. A.
doaj   +1 more source

Relationship between continuous infusion meropenem PK/PD target attainment and C‐reactive protein dynamics in onco‐haematologic patients with febrile neutropenia

British Journal of Clinical Pharmacology, EarlyView.
Aim Meropenem is a second‐line antimicrobial agent in the treatment of febrile neutropenia in onco‐haematological patients. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between meropenem exposure and C‐reactive protein (C‐RP) over time was conducted.
Chun Liu, Pier Giorgio Cojutti, J. G. Coen van Hasselt, Michele Bartoletti, Maddalena Giannella, Pierluigi Zinzani, Pierluigi Viale, Federico Pea   +7 more
wiley   +1 more source

Integrating CRRT as a Virtual Organ Into Physiologically Based Pharmacokinetic Modeling to Optimize Antimicrobial Dosing in Septic Patients. [PDF]

CPT Pharmacometrics Syst Pharmacol
Development and application of PBPK modeling integrating CRRT as a virtual organ to characterize antimicrobial pharmacokinetics and optimize dosing in septic patients. ABSTRACT Continuous renal replacement therapy (CRRT) extracorporeal drug removal, sepsis‐related pathophysiological alterations, and reduced pathogen susceptibility to antimicrobials can
Xing Y, Zhang Y, Bai C, Qiu Y, Wang C, Chen L, Wang T, Chen J.   +7 more
europepmc   +2 more sources