Results 21 to 30 of about 78,101 (219)

Appropriate Use of Meropenem: A Pharmacy Intervention

, 2014
Class of 2014 AbstractSpecific Aims: The primary objective was to determine the effectiveness of a criteria-based antibiotic order form (CBAOF) at increasing appropriate meropenem use at University of Arizona Medical Center –South Campus (UAMCSC).
Natkowski, Jamie, Rubal-Peace, Georgina, Stacey Abbott   +2 more
core   +5 more sources

Synergistic activity of fosfomycin–meropenem and fosfomycin–colistin against carbapenem resistant Klebsiella pneumoniae: an in vitro evidence

Future Science OA, 2020
Aim: To evaluate the antibacterial activity of fosfomycin–meropenem and fosfomycin–colistin combinations against carbapenem-resistant Klebsiella pneumoniae (CR-Kp). Methods: A total of 50 CR-Kp isolates recovered from blood cultures were included in this
Yamuna Devi Bakthavatchalam, Abirami Shankar, Dhiviya Prabaa Muthuirulandi Sethuvel, Kalaiarasi Asokan, Kalaiarasi Kanthan, Balaji Veeraraghavan   +5 more
doaj   +1 more source

The Outcome of Antibiotic Overuse before and during the COVID-19 Pandemic in a Tertiary Care Hospital in Oman

Antibiotics, 2023
Antimicrobial resistance (AMR), a serious global public health challenge, may have accelerated development during the COVID-19 pandemic because antibiotics were prescribed for COVID-19.
Nenad Pandak, Hilal Al Sidairi, Ibrahim Al-Zakwani, Zakariya Al Balushi, Shabnam Chhetri, Muna Ba’Omar, Sultan Al Lawati, Seif S. Al-Abri, Faryal Khamis   +8 more
doaj   +1 more source

Liquid Chromatography-Tandem Mass Spectrometry Analysis Demonstrates a Decrease in Porins and Increase in CMY-2 β-Lactamases in Escherichia coli Exposed to Increasing Concentrations of Meropenem

Frontiers in Microbiology, 2022
While Extended-Spectrum β-Lactamases (ESBL) and AmpC β-lactamases barely degrade carbapenem antibiotics, they are able to bind carbapenems and prevent them from interacting with penicillin-binding proteins, thereby inhibiting their activity.
Dimard E. Foudraine, Camiel N. M. Aarents, Agnes A. Wattel, Ria van Boxtel, Nikolaos Strepis, Marian T. ten Kate, Annelies Verbon, Theo M. Luider, Corné H. W. Klaassen, John Hays, Lennard J. M. Dekker, Jan Tommassen, Wil H. F. Goessens   +12 more
doaj   +1 more source

Transporter-Drive Interstitial Tissue Exposure and Pharmacodynamic Response of Meropenem in Sepsis: A Mechanistic PBPK Modeling Study. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT A whole‐body mechanistic PBPK model for meropenem (MPN) was developed in PK‐Sim and validated using published plasma and tissue concentration–time data in healthy volunteers and critically ill patients. Renal elimination was implemented as glomerular filtration plus active tubular secretion (basolateral uptake via OAT3 with apical efflux), and
Olivo LB, de Lemos JLS, Rodrigues VJ, de Araújo BV.   +3 more
europepmc   +2 more sources

In Vitro Meropenem/Antibiotic and Meropenem/Bacteriophage Combinations Against Carbapenem-Resistant Gram-Negative Uropathogens [PDF]

, 2023
Introduction Carbapenem antibiotics are among the last-resort treatments for infections caused by multidrug-resistant bacteria. The emergence and spread of carbapenem resistance (CR) have led researchers to seek alternative treatment approaches to ...
Khaled M. Aboshanab, Ann A. Elshamy, Mohammad M. Aboulwafa, Nadia A. Hassouna, Sarra E. Saleh   +4 more
core   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Exogenous glutathione reverses meropenem resistance in carbapenem-resistant Klebsiella pneumoniae

Frontiers in Pharmacology, 2023
Background: The rate of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection has been increasing rapidly worldwide and, poses a significant risk to human health.
Juan Yi, Juan Yi, Chao Liu, Chao Liu, Ping Yang, Ping Yang, Zhen-chao Wu, Zhen-chao Wu, Chun-jing Du, Chun-jing Du, Ning Shen, Ning Shen, Ning Shen, Ning Shen   +13 more
doaj   +1 more source

Efektivitas Meropenem-Levofloxacin dengan Meropenem-Amikasin terhadap LOS & Leukosit Pasien Pneumonia Komuniti Stratifikasi III RASPRO [PDF]

, 2020
Administration of antibiotics in the private hospital "X" adopted a concept called RonaldIrwanto Antimicrobial Steweardship Program (RASPRO). The suggestion of an empirical antibioticcombination in type III stratifi cation community pneumonia patients ...
Sumarsono, Hadi, Laksmitawati, Dian Ratih, Irwanto, Ronald   +2 more
core   +1 more source

Comparison of Pharmaceutical Characteristics between Brand-Name Meropenem and Its Generics

Antibiotics, 2021
This study aimed to provide comparative information of pharmaceutical properties, including particle morphology and distribution uniformity, solubility, presence of residual solvent and insoluble particles, and antimicrobial activities, between brand ...
Ping Yang, Shigeru Fujimura, Yawei Du, Bei Zhang, Li Yang, Masato Kawamura, Zhenhua Zhang, Suodi Zhai   +7 more
doaj   +1 more source