Results 11 to 20 of about 89,290 (238)

Dried Plasma Spot Based LC–MS/MS Method for Monitoring of Meropenem in the Blood of Treated Patients

Molecules, 2022
Meropenem (MER) is widely used to treat complicated and serious infections. Therapeutic drug monitoring (TDM) provides a valid clinical tool to avoid suboptimal concentrations and dose–related adverse reactions.
Haiwei Cao, Yi Jiang, Shaomin Wang, Haihuan Cao, Yanyan Li, Jing Huang   +5 more
doaj   +1 more source

Evaluation of a Meropenem and Piperacillin Monitoring Program in Intensive Care Unit Patients Calls for the Regular Assessment of Empirical Targets and Easy-to-Use Dosing Decision Tools

Antibiotics, 2022
The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of the pathogen. Yet, the pathogen is often unknown, and antibiotic therapy is guided by empirical targets.
Ferdinand Anton Weinelt, Miriam Songa Stegemann, Anja Theloe, Frieder Pfäfflin, Stephan Achterberg, Franz Weber, Lucas Dübel, Agata Mikolajewska, Alexander Uhrig, Peggy Kiessling, Wilhelm Huisinga, Robin Michelet, Stefanie Hennig, Charlotte Kloft   +13 more
doaj   +1 more source

Increased blaKPC Copy Number and OmpK35 and OmpK36 Porins Disruption Mediated Resistance to Imipenem/Relebactam and Meropenem/Vaborbactam in a KPC-Producing Klebsiella pneumoniae Clinical Isolate

Antimicrobial Agents and Chemotherapy, 2022
Herein, we report the in vivo evolution of imipenem/relebactam-resistance in KPC-producing K. pneumoniae (KPC-Kp) isolated from a critically-ill patient treated with multiple combination therapies based on ceftazidime-avibactam or meropenem-vaborbactam ...
P. Gaibani, G. Bianco, Stefano Amadesi, M. Boattini, S. Ambretti, C. Costa   +5 more
semanticscholar   +1 more source

Effect of Different Approaches to Antimicrobial Therapy with Cefmetazole and Meropenem on the Time to Defervescence in Non-Severe Extended-Spectrum β-Lactamase-Producing Escherichia coli Bacteremia

Infectious Disease Reports, 2023
Carbapenems are antimicrobial agents commonly used to treat extended-spectrum β-lactamase (ESBL)-producing bacteria. Although cefmetazole (CMZ) is considered effective for ESBL-producing Escherichia coli (ESBL-EC) bacteremia, previous studies showed its ...
Takanobu Hoshi, Satoshi Fujii, Kei Watanabe, Yuta Fukumura, Koji Miyazaki, Madoka Takahashi, Sakae Taniguchi, Shingo Kimura, Arisa Saito, Naoki Wada, Masaji Saijo, Kazunori Yamada, Kuninori Iwayama, Marie Itaya, Hideki Sato   +14 more
doaj   +1 more source

Epidemiology of Carbapenem Resistance Determinants Identified in Meropenem-Nonsusceptible Enterobacterales Collected as Part of a Global Surveillance Program, 2012 to 2017

Antimicrobial Agents and Chemotherapy, 2021
To estimate the incidence of carbapenem-resistant Enterobacterales (CRE), a global collection of 81,781 surveillance isolates of Enterobacterales collected from patients in 39 countries in five geographic regions from 2012 to 2017 was studied. Overall, 3.
K. Kazmierczak, J. Karlowsky, B. D. de Jonge, G. Stone, D. Sahm   +4 more
semanticscholar   +1 more source

Effectiveness and Nephrotoxicity of Loading Dose Colistin–Meropenem versus Loading Dose Colistin–Imipenem in the Treatment of Carbapenem-Resistant Acinetobacter baumannii Infection

Pharmaceutics, 2022
Carbapenem-resistant Acinetobacter baumannii (CRAB) is becoming more widely recognized as a serious cause of nosocomial infections, and colistin has been reintroduced in recent years for the treatment of CRAB infection.
Wasan Katip, Peninnah Oberdorfer, Nongyao Kasatpibal   +2 more
semanticscholar   +1 more source

Meropenem use and therapeutic drug monitoring in clinical practice: a literature review

Journal of Clinical Pharmacy and Therapeutics, 2021
Meropenem, a carbapenem antibiotic, is widely prescribed for the treatment of life‐threatening infections. The main parameter associated with its therapeutic success is the percentage of time that the levels remain above the minimum inhibitory ...
N. A. Steffens, E. Zimmermann, S. M. Nichelle, Natália Brucker   +3 more
semanticscholar   +1 more source

Meropenem Versus Piperacillin-Tazobactam for Definitive Treatment of Bloodstream Infections Caused by AmpC β-Lactamase–Producing Enterobacter spp, Citrobacter freundii, Morganella morganii, Providencia spp, or Serratia marcescens: A Pilot Multicenter Randomized Controlled Trial (MERINO-2)

Open Forum Infectious Diseases, 2021
Background Carbapenems are recommended treatment for serious infections caused by AmpC-producing gram-negative bacteria but can select for carbapenem resistance. Piperacillin-tazobactam may be a suitable alternative.
Adam G. Stewart, D. Paterson, B. Young, D. Lye, Joshua S. Davis, K. Schneider, M. Yılmaz, Rümeysa Di̇nleyi̇ci̇, Naomi Runnegar, A. Henderson, S. Archuleta, S. Kalimuddin, B. Forde, M. Chatfield, M. Bauer, J. Lipman, T. Harris-Brown, P. Harris   +17 more
semanticscholar   +1 more source

Prevalence of Aerobic Organisms in Surgical Site and Ulcerations at a Tertiary Rural Hospital in Mandya, Karnataka, India

International Journal of Anatomy Radiology and Surgery, 2022
Introduction: In an era in which the cost of treatment is an increasing source of concern in wound management in surgery, wound infection increases costs and hospital stay.
Rochelle D’Souza, Shilpashree Channasandra Shekar, Suhas Narayanswamy Gowda, N Naveen   +3 more
doaj   +1 more source

Colistin Monotherapy versus Colistin plus Meropenem Combination Therapy for the Treatment of Multidrug-Resistant Acinetobacter baumannii Infection: A Meta-Analysis

Journal of Clinical Medicine, 2022
(1) Introduction: Colistin combination therapy with other antibiotics is a way to enhance colistin activity. The purpose of this meta-analysis was to compare the efficacy and safety of treatment with colistin monotherapy versus colistin plus meropenem ...
Chienhsiu Huang, I. Chen, Tiju Tang
semanticscholar   +1 more source