Results 1 to 10 of about 75,632 (172)

Molecular aspects of MERS-CoV [PDF]

Frontiers of Medicine, 2017
Middle East respiratory syndrome coronavirus (MERS-CoV) is a betacoronavirus which can cause acute respiratory distress in humans and is associated with a relatively high mortality rate. Since it was first identified in a patient who died in a Jeddah hospital in 2012, the World Health Organization has been notified of 1735 laboratory-confirmed cases ...
Rabaan, Ali A., Bazzi, Ali M., Al-Ahmed, Shamsah H., Al-Tawfiq, Jaffar A.   +3 more
openaire   +6 more sources

Immunization of MERS-CoV-2-infected mice with a sublethal dose of MERS-CoV or VRP-MERS-S. [PDF]

STAR Protoc, 2023
Here, we detail the immunization of mice with a sublethal dose of MERS-CoV or two doses of replication-incompetent alphavirus replicon particles expressing MERS-CoV spike protein. We then describe steps to determine the outcome of immunization by challenging immunized mice with a lethal dose of MERS-CoV, as well as by detecting virus-specific ...
Zheng J, Channappanavar R, Perlman S.
europepmc   +4 more sources

Drivers of MERS-CoV Emergence in Qatar [PDF]

Viruses, 2018
MERS-CoV (Middle East respiratory syndrome corona virus) antibodies were detected in camels since 1983, but the first human case was only detected in 2012. This study sought to identify and quantify possible drivers for the MERS-CoV emergence and spillover to humans. A list of potential human, animal and environmental drivers for disease emergence were
Elmoubasher Farag, Reina S. Sikkema, Tinka Vinks, Md Mazharul Islam, Mohamed Nour, Hamad Al-Romaihi, Mohammed Al Thani, Muzzamil Atta, Farhoud H. Alhajri, Salih Al-Marri, Mohd AlHajri, Chantal Reusken, Marion Koopmans   +12 more
openaire   +11 more sources

MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic [PDF]

Emerging Infectious Diseases, 2016
To the Editor: Accumulating evidence indicates that dromedaries (Camelus dromedarius) are a reservoir for zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV). Although numerous studies have looked at other livestock in the Middle East region, evidence for MERS-CoV infection has only been found in dromedaries (1).
Reusken, Chantal B.E.M., Schilp, Chrispijn, Raj, V. Stalin, De Bruin, Erwin, Kohl, Robert H.G., Farag, Elmoubasher A.B.A., Haagmans, Bart L., Al-Romaihi, Hamad, Le Grange, Francois, Bosch, Berend-Jan, Koopmans, Marion P.G.   +10 more
openaire   +5 more sources

MERS-CoV: Ein aktueller Überblick [PDF]

Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie, 2013
The following article gives a current overview of the newly emerging Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Since first time in summer 2012 in some countries in the Arabian Peninsula there were a number of severe infections of the respiratory tract caused by the new coronavirus.
Matthias Bundschuh, Doris Klingelhoefer
openaire   +2 more sources

Pilgrims and MERS-CoV: what’s the risk? [PDF]

Emerging Themes in Epidemiology, 2015
The risk of Middle East Respiratory Syndrome Coronavirus spreading globally is worrying, given the annual mass gathering of the Hajj and the year-long influx of pilgrims undertaking the Umrah. Based on the incidence in Saudi Arabia since June 2012, the most likely scenario given recent pilgrim numbers is estimated to be one case per Hajj, and three ...
Tarek Soliman, Richard Coker, Richard Coker, Alex R. Cook, Alex R. Cook   +4 more
openaire   +4 more sources

Unraveling the drivers of MERS-CoV transmission [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Since it was discovered in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has infected more than 1,700 persons, one-third of whom died, essentially in the Middle East. Persons can get infected by direct or indirect contact with dromedary camels, and although human-to-human transmission is not self-sustaining in the
Simon Cauchemez, Pierre Nouvellet, Anne Cori, Thibaut Jombart, Tini Garske, Hannah Clapham, Sean Moore, Harriet Linden Mills, Henrik Salje, Caitlin Collins, Isabel Rodriquez-Barraquer, Steven Riley, Shaun Truelove, Homoud Algarni, Rafat Alhakeem, Khalid AlHarbi, Abdulhafiz Turkistani, Ricardo J. Aguas, Derek A. T. Cummings, Maria D. Van Kerkhove, Christl A. Donnelly, Justin Lessler, Christophe Fraser, Ali Al-Barrak, Neil M. Ferguson   +24 more
openaire   +7 more sources

Growth and Quantification of MERS‐CoV Infection [PDF]

Current Protocols in Microbiology, 2015
AbstractMiddle East respiratory syndrome coronavirus (MERS‐CoV) is an emerging highly pathogenic respiratory virus. Although MERS‐CoV only emerged in 2012, we and others have developed assays to grow and quantify infectious MERS‐CoV and RNA products of replication in vitro. MERS‐CoV is able to infect a range of cell types, but replicates to high titers
Christopher M. Coleman, Matthew B. Frieman   +1 more
openaire   +2 more sources

MERS-CoV diagnosis: An update

Journal of Infection and Public Health, 2016
Diagnosis of MERS-Cov still a major concern in most of daignostic laboratories. To date the Real-time Polymerase Chain reaction (RT-PCR) is the mainstay for diagnosis of MERS-CoV. RT-PCR has limitations, including a long turnaround time and lack of common measurements and correlations with Viral Load (VL). It is recommended to screen for MERS-CoV using
Sameera M. Al Johani, Ali H. Hajeer
openaire   +4 more sources

Prospects for a MERS-CoV spike vaccine [PDF]

Expert Review of Vaccines, 2018
Six years have passed since Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV), a newly emerging infectious virus, was first reported in 2012. Although MERS-CoV has had a consistently high mortality rate in humans, no vaccines have been approved to prevent MERS-CoV infection in humans.
Yusen Zhou, Lanying Du, Shibo Jiang
openaire   +4 more sources