Results 51 to 60 of about 444,796 (301)

Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns [PDF]

, 2016
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A., Omrani, Ali S.   +2 more
core   +1 more source

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs

Nature Genetics, 2022
CRISPR knockout (KO) screens have identified host factors regulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication. Here, we conducted a meta-analysis of these screens, which showed a high level of cell-type specificity of the ...
A. Rebendenne, Priyanka Roy, Boris Bonaventure, Ana Luiza Chaves Valadão, L. Desmarets, M. Arnaud-Arnould, Y. Rouillé, Marine Tauziet, D. Giovannini, Jawida Touhami, Yenarae Lee, Peter C. DeWeirdt, Mudra Hegde, S. Urbach, Khadija El Koulali, Francisco Garcia de Gracia, J. McKellar, J. Dubuisson, Mélanie Wencker, S. Belouzard, O. Moncorgé, John G Doench, C. Goujon   +22 more
semanticscholar   +1 more source

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Journal of Virology, 2020
The bifunctional nsp14 subunit of the coronavirus replicase contains 3′-to-5′ exoribonuclease (ExoN) and guanine-N7-methyltransferase domains. For the betacoronaviruses MHV and SARS-CoV, ExoN was reported to promote the fidelity of genome replication ...
N. Ogando, Jessika C. Zevenhoven-Dobbe, Y. van der Meer, P. Bredenbeek, C. Posthuma, E. Snijder   +5 more
semanticscholar   +1 more source

MERS-CoV diagnosis: An update

Journal of Infection and Public Health, 2016
Diagnosis of MERS-Cov still a major concern in most of daignostic laboratories. To date the Real-time Polymerase Chain reaction (RT-PCR) is the mainstay for diagnosis of MERS-CoV. RT-PCR has limitations, including a long turnaround time and lack of common measurements and correlations with Viral Load (VL). It is recommended to screen for MERS-CoV using
Sameera M. Al Johani, Ali H. Hajeer
openaire   +4 more sources

Designing a multi-epitope vaccine candidate to combat MERS-CoV by employing an immunoinformatics approach

Scientific Reports, 2021
Currently, no approved vaccine is available against the Middle East respiratory syndrome coronavirus (MERS-CoV), which causes severe respiratory disease. The spike glycoprotein is typically considered a suitable target for MERS-CoV vaccine candidates.
S. Mahmud, Md. Oliullah Rafi, Gobindo Kumar Paul, Maria Meha Promi, M. Shimu, Suvro Biswas, T. Emran, K. Dhama, S. Alyami, M. A. Moni, M. Saleh   +10 more
semanticscholar   +1 more source

Healthcare Workers Emotions, Perceived Stressors and Coping Strategies During a MERS-CoV Outbreak

Clinical Medicine Research, 2016
Objective Healthcare workers (HCWs) are at high risk of contracting Middle East respiratory syndrome coronavirus (MERS-CoV) during an epidemic. We explored the emotions, perceived stressors, and coping strategies of healthcare workers who worked during a
I. Khalid, T. Khalid, Mohammed R. Qabajah, Aletta G Barnard, I. Qushmaq   +4 more
semanticscholar   +1 more source

The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV

Archives of Virology, 2021
The number of descriptions of emerging viruses has grown at an unprecedented rate since the beginning of the 21 st century. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is the third ...
Nima Hemmat, Zahra Asadzadeh, Noora Karim Ahangar, H. Alemohammad, Basira Najafzadeh, A. Derakhshani, A. Baghbanzadeh, H. B. Baghi, Darya Javadrashid, S. Najafi, Meriadeg Ar Gouilh, B. Baradaran   +11 more
semanticscholar   +1 more source

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

Nature Communications, 2017
The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host tropism and entry into host cells, and constitute a promising target for the development of prophylactics and therapeutics.
Yuan Yuan, D. Cao, Yanfang Zhang, Jun Ma, J. Qi, Qihui Wang, G. Lu, Ying Wu, Jinghua Yan, Yi Shi, Xinzheng Zhang, G. Gao   +11 more
semanticscholar   +1 more source

3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice

Science Translational Medicine, 2020
Optimized small-molecule 3C-like protease inhibitors show potency against human coronaviruses in both cell culture and a mouse model. Targeting coronavirus 3CLpro Coronavirus 3C-like proteases (3CLpro) are attractive therapeutic targets because they play
A. Rathnayake, Jian Zheng, Yunjeong Kim, K. D. Perera, Samantha R. Mackin, D. Meyerholz, M. Kashipathy, K. Battaile, S. Lovell, S. Perlman, W. Groutas, Kyeong-Ok Chang   +11 more
semanticscholar   +1 more source

MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

Vaccine, 2017
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces
Thiagarajan Venkataraman, Gale Smith, David Flyer, Ye V. Liu, Gregory M. Glenn, Matthew B. Frieman, Christopher M. Coleman   +6 more
openaire   +2 more sources