Results 81 to 90 of about 444,796 (301)

Virtual Screening and Inhibition of Middle East Respiratory Syndrome Coronavirus Replication by Targeting Papain-like Protease

Dr. Sulaiman Al Habib Medical Journal, 2021
Infection by the emerging, potentially zoonotic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) presents a severe health hazard to humans and is often fatal.
Mahmoud Kandeel, Byoung Kwon Park, Mohamed A. Morsy, Katharigatta N. Venugopala, Kentaro Oh-hashi, Mohammed Al-Nazawi, Hyung-Joo Kwon   +6 more
doaj   +1 more source

Cross host transmission in the emergence of MERS coronavirus [PDF]

, 2016
Coronaviruses (CoVs) able to infect humans emerge through cross-host transmission from animals. There is substantial evidence that the recent Middle East respiratory syndrome (MERS)-CoV outbreak is fueled by zoonotic transmission from dromedary camels ...
Haagmans, B.L. (Bart), Koopmans D.V.M., M.P.G. (Marion), Raj, V.S. (Stalin), Reusken, C.B.E.M. (Chantal)   +3 more
core   +1 more source

The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV

Scientific Reports, 2020
The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680SPRRAR↓SV687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target cells.
Mihkel Örd, I. Faustova, M. Loog
semanticscholar   +1 more source

MERS-CoV spillover at the camel-human interface [PDF]

eLife, 2017
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus from camels causing significant mortality and morbidity in humans in the Arabian Peninsula. The epidemiology of the virus remains poorly understood, and while case-based and seroepidemiological studies have been employed extensively throughout the epidemic, viral sequence data ...
Dudas, Gytis, Carvalho, Luiz Max, Rambaut, Andrew, Bedford, Trevor, Somily, Ali M., Barry, Mazin, Al Subaie, Sarah S., BinSaeed, Abdulaziz A., Alzamil, Fahad A., Zaher, Waleed, Qahtani, Theeb Al, Jerian, Khaldoon Al, McNabb, Scott J.N., Al-Jahdali, Imad A., Alotaibi, Ahmed M., Batarfi, Nahid A., Cotten, Matthew, Watson, Simon J., Binter, Spela, Kellam, Paul   +19 more
openaire   +5 more sources

Immunization of MERS-CoV-2-infected mice with a sublethal dose of MERS-CoV or VRP-MERS-S

STAR Protocols, 2023
Here, we detail the immunization of mice with a sublethal dose of MERS-CoV or two doses of replication-incompetent alphavirus replicon particles expressing MERS-CoV spike protein. We then describe steps to determine the outcome of immunization by challenging immunized mice with a lethal dose of MERS-CoV, as well as by detecting virus-specific ...
Jian Zheng, Rudra Channappanavar, Stanley Perlman   +2 more
openaire   +3 more sources

MERS-CoV at the animal–human interface: inputs on exposure pathways from an expert-opinion elicitation [PDF]

, 2016
Nearly 4 years after the first report of the emergence of Middle-East respiratory syndrome Coronavirus (MERS-CoV) and nearly 1800 human cases later, the ecology of MERS-CoV, its epidemiology, and more than risk factors of MERS-CoV transmission between ...
Anna Funk, Bernard Faye, Eve Miguel, Flavie Luce Goutard, FRANCOIS LOUIS ROGER, JS Malik Peiris, JS Malik Peiris, Maria D Van Kerkhove, Mathieu Bourgarel, Veronique Chevalier   +9 more
core   +2 more sources

Nanomaterial‐Based Optical Biosensors for SARS‐CoV‐2 Detection: A Retrospective of the Pandemic

Advanced Sensor Research, EarlyView.
This review discusses nanomaterial‐based optical biosensors developed for or adapted to the detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). It concludes by providing a perspective on how lessons learned during the coronavirus disease of 2019 (COVID‐19) pandemic may be applied for future research on nanomaterial‐based ...
Flavie Martin, Scott G. Harroun, Michel Meunier   +2 more
wiley   +1 more source

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

Journal of Infectious Diseases, 2015
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe disease in human with an overall case-fatality rate of >35%. Effective antivirals are crucial for improving the clinical outcome of MERS.
J. Chan, Yanfeng Yao, M. Yeung, Wei Deng, L. Bao, L. Jia, Feng-di Li, C. Xiao, Hong Gao, Pin Yu, Jian-Piao Cai, Hin Chu, Jie Zhou, Honglin Chen, C. Qin, K. Yuen   +15 more
semanticscholar   +1 more source

Limited Genetic Diversity Detected in Middle East Respiratory Syndrome-Related Coronavirus Variants Circulating in Dromedary Camels in Jordan

Viruses, 2021
Middle East respiratory syndrome-related coronavirus (MERS-CoV) is a persistent zoonotic pathogen with frequent spillover from dromedary camels to humans in the Arabian Peninsula, resulting in limited outbreaks of MERS with a high case-fatality rate ...
Stephanie N. Seifert, Jonathan E. Schulz, Stacy Ricklefs, Michael Letko, Elangeni Yabba, Zaidoun S. Hijazeen, Peter Holloway, Bilal Al-Omari, Hani A. Talafha, Markos Tibbo, Danielle R. Adney, Javier Guitian, Nadim Amarin, Juergen A. Richt, Chester McDowell, John Steel, Ehab A. Abu-Basha, Ahmad M. Al-Majali, Neeltje van Doremalen, Vincent J. Munster   +19 more
doaj   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source