Results 81 to 90 of about 85,740 (261)

Unraveling the drivers of MERS-CoV transmission [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Since it was discovered in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has infected more than 1,700 persons, one-third of whom died, essentially in the Middle East. Persons can get infected by direct or indirect contact with dromedary camels, and although human-to-human transmission is not self-sustaining in the
Simon Cauchemez, Pierre Nouvellet, Anne Cori, Thibaut Jombart, Tini Garske, Hannah Clapham, Sean Moore, Harriet Linden Mills, Henrik Salje, Caitlin Collins, Isabel Rodriquez-Barraquer, Steven Riley, Shaun Truelove, Homoud Algarni, Rafat Alhakeem, Khalid AlHarbi, Abdulhafiz Turkistani, Ricardo J. Aguas, Derek A. T. Cummings, Maria D. Van Kerkhove, Christl A. Donnelly, Justin Lessler, Christophe Fraser, Ali Al-Barrak, Neil M. Ferguson   +24 more
openaire   +6 more sources

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Domestic Pig Unlikely Reservoir for MERS-CoV [PDF]

Emerging Infectious Diseases, 2017
We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a reservoir in nature.
Emmie de Wit, Friederike Feldmann, Eva Horne, Cynthia Martellaro, Elaine Haddock, Trenton Bushmaker, Kyle Rosenke, Atsushi Okumura, Rebecca Rosenke, Greg Saturday, Dana Scott, Heinz Feldmann   +11 more
openaire   +3 more sources

CRISPR in MOF Formulation with Enhanced Stability, Activity, and Altered PAM Specificity for Broad‐Spectrum Diagnosis of Bacterial Sepsis

Advanced Science, EarlyView.
CRISPR‐FLEXMO (CRISPR with flexible PAM in MOF encapsulation) integrates a PAM‐relaxed Cas12a K607R enzyme with a manganese‐coordinated MOF for broad‐spectrum diagnosis of bacterial sepsis. The MOF enhances activity and preserves functionality under heat, solvent, and chaotropic stress, supporting long‐term room‐temperature storage.
Tathagata Pal, Zilong Liu, Meera G. Nair, Juhong Chen   +3 more
wiley   +1 more source

Detection of the Middle East Respiratory Syndrome Coronavirus Genome in an Air Sample Originating from a Camel Barn Owned by an Infected Patient

mBio, 2014
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel betacoronavirus that has been circulating in the Arabian Peninsula since 2012 and causing severe respiratory infections in humans.
Esam I. Azhar, Anwar M. Hashem, Sherif A. El-Kafrawy, Sayed Sartaj Sohrab, Asad S. Aburizaiza, Suha A. Farraj, Ahmed M. Hassan, Muneera S. Al-Saeed, Ghazi A. Jamjoom, Tariq A. Madani   +9 more
doaj   +1 more source

Emerging respiratory viral infections: MERS-CoV and influenza [PDF]

, 2014
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
core   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Infectious diseases epidemic threats and mass gatherings: refocusing global attention on the continuing spread of the Middle East Respiratory syndrome coronavirus (MERS-CoV) [PDF]

, 2016
Media and World Health Organization (WHO) attention on Zika virus transmission at the 2016 Rio Olympic Games and the 2015 Ebola virus outbreak in West Africa diverted the attention of global public health authorities from other lethal infectious diseases
Alagaili, AN, Azhar, EI, Cotten, M, Zumla, A   +3 more
core   +4 more sources

Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria, 2015 [PDF]

, 2015
Evidence of current and past Middle East respiratory syndrome coronavirus (MERS-CoV) infection in dromedary camels slaughtered at an abattoir in Kano, Nigeria in January 2015, was sought by reverse transcription-quantitative polymerase chain reaction (RT-
Chan, MS, Chu, KW, Kuranga, SA, Oladipo, JO, Peiris, JSM, Perera, RAPM, Poon, LLM   +6 more
core   +1 more source

Assessing the pandemic potential of MERS-CoV [PDF]

The Lancet, 2013
The final publication is available at Elsevier via http://dx.doi.org/10.1016/S0140-6736(13)61504-4 © 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
Bauch, Chris T, Oraby, Tamer
openaire   +2 more sources