Results 91 to 100 of about 467,339 (358)
Diminishing Return for Increased Mappability with Longer Sequencing Reads: Implications of the k-mer Distributions in the Human Genome [PDF]
, 2013 The amount of non-unique sequence (non-singletons) in a genome directly affects the difficulty of read alignment to a reference assembly for high throughput-sequencing data.
Freudenberg, Jan +2 more
core +2 more sources
A lesson learned from the MERS epidemic in Korea: an essay on MERS [PDF]
Epidemiology and Health, 2015 In the mid-1970s, a literary magazine published in Seoul had asked a number of people in the natural sciences, to write a short science fiction about Korean society a hundred years in the future. They were the ones who from time to time contributed life sciences-related articles to various press media. I was also requested to write a manuscript for the
openaire +4 more sources
Advanced Science, EarlyView.DeepTFBS leverages deep learning to predict transcription factor binding sites across species, integrating multi‐task and transfer learning approaches to improve performance in data‐scarce scenarios. This study demonstrates enhanced accuracy in intra‐ and cross‐species prediction, revealing conserved regulatory patterns and functional variants.
Jingjing Zhai +8 more
wiley +1 more source
Gerbil: A Fast and Memory-Efficient $k$-mer Counter with GPU-Support [PDF]
, 2016 A basic task in bioinformatics is the counting of $k$-mers in genome strings. The $k$-mer counting problem is to build a histogram of all substrings of length $k$ in a given genome sequence.
Erbert, Marius +2 more
core +2 more sources
Advanced Science, EarlyView.The waterlogging tolerance of allotetraploid Actinidia valvata is inherited from one of its diploid progenitors, which leads to subgenome expression dominance, mediated by complex mechanisms including altered chromatin accessibility and DNA methylation.
Xiaoli Hu +14 more
wiley +1 more source
Vaccines for epidemic infections and the role of CEPI
Human Vaccines & Immunotherapeutics, 2017 The author reviews the foundation of the Coalition for Epidemic Preparedness and Innovations and the choices it has made for funding of vaccine development against epidemic diseases.
Stanley A. Plotkin
doaj +1 more source
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
Advanced Science, EarlyView.Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz +24 more
wiley +1 more source
Prospects for a MERS-CoV spike vaccine
Expert Review of Vaccines, 2018 Introduction: Six years have passed since Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV), a newly emerging infectious virus, was first reported in 2012.
Yusen Zhou, Shibo Jiang, Lanying Du
doaj +1 more source
Epidemics and Reforms: Experience of Saudi Arabia
Международная аналитика, 2020 Saudi Arabia is one of the key countries in the Middle East and the Arab-Muslim world. The processes developing in this country, determined by both internal and external factors, are directly related to the development of the surrounding geopolitical ...
G. G. Kosach
doaj +1 more source