Results 71 to 80 of about 3,785 (176)

The first RNAi‐based biopesticide approved in the United States: regulatory implications for the European Union – the case of Ledprona (Calantha™)

Pest Management Science, EarlyView.
The approval of the RNA interference‐based biopesticide Ledprona (Calantha™) in the USA marks a milestone for RNA‐based crop protection. We discuss the regulatory implications for the European Union, highlighting opportunities, challenges, and the need for adapted risk assessment frameworks for RNA‐based plant protection products.
Aline Koch, Gabi Krczal
wiley   +1 more source

Cotton Farming Pesticides Affect Ileal Microbiota Activity and Expression of Virulome but Not Resistome or Metabolic Pathways in a Sedentary Wild Passerine

Environmental Toxicology, EarlyView.
ABSTRACT The increased use of agrochemicals to enhance crop production has had detrimental environmental effects including implication in the sharp decline of North American farmland‐breeding birds. Here, using a combination of deep shotgun metatranscriptomics and pesticide exposure data, we sought to assess whether exposure to cotton (Gossypium spp ...
Serguei V. Drovetski, Michelle L. Hladik, Carolina F. Ferreira, Dana W. Kolpin, Gary Voelker   +4 more
wiley   +1 more source

Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection

Emerging Microbes and Infections, 2019
In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%.
Danielle R. Adney, Michael Letko, Izabela K. Ragan, Dana Scott, Neeltje van Doremalen, Richard A. Bowen, Vincent J. Munster   +6 more
doaj   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Cell Reports, 2018
Summary: The major mechanism of antibody-mediated neutralization of the Middle East respiratory syndrome coronavirus (MERS-CoV) involves competition with the cellular receptor dipeptidyl peptidase 4 (DPP4) for binding to the receptor-binding domain (RBD)
Senyan Zhang, Panpan Zhou, Pengfei Wang, Yangyang Li, Liwei Jiang, Wenxu Jia, Han Wang, Angela Fan, Dongli Wang, Xuanling Shi, Xianyang Fang, Michal Hammel, Shuying Wang, Xinquan Wang, Linqi Zhang   +14 more
doaj   +1 more source

Separating the effects of temperature and absorbed X‐ray dose on unit‐cell volume

Acta Crystallographica Section D, EarlyView.
The nature of the expansion of the crystal unit‐cell volume with absorbed dose and with temperature was examined for three different proteins.The behaviour of the unit‐cell volume of crystals of the iron‐storage molecule ferritin, both in the apo and the holo form, and of influenza A virus subtype N9 neuraminidase at 100 K and over a controlled cryo ...
Robert J. Southworth-Davies, James W. Murray, Ian Carmichael, Enrique Rudiño-Piñera, Martin Weik, Elspeth F. Garman   +5 more
wiley   +1 more source

CD8+ T Cells Responding to the Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Delivered by Vaccinia Virus MVA in Mice

Viruses, 2018
Middle East respiratory syndrome coronavirus (MERS-CoV), a novel infectious agent causing severe respiratory disease and death in humans, was first described in 2012.
Svenja Veit, Sylvia Jany, Robert Fux, Gerd Sutter, Asisa Volz   +4 more
doaj   +1 more source

Toasting With Strangers? Export Spillovers From Chinese Winery Acquisitions in the Bordeaux Vineyards

British Journal of Management, EarlyView.
Abstract Foreign entrants may threaten and, at the same time, present local companies with opportunities for favourable spillovers. Building on the awareness‐motivation‐capability framework, this paper aims to provide empirical evidence for a positive co‐location or spatial proximity effect of foreign presence on local peer companies’ exports.
Pierre‐Xavier Meschi, Alexandre Bohas, Anne Norheim‐Hansen   +2 more
wiley   +1 more source

Meningitis-Retention Syndrome with mild encephalitis/ encephalopathy with reversible splenial lesion

Journal of Hospital General Medicine
Meningitis-retention syndrome is a rare condition characterized by meningitis with urinary retention. We report a case of recurrent meningitis-retention syndrome as a symptom of mild encephalitis/encephalopathy with reversible splenial lesion in a 42 ...
Naoko Makishi, Yasuharu Tokuda
doaj   +1 more source

Whole‐Genome Sequencing and Resequencing of Hucho bleekeri Provides Insights into Genetic Mechanisms of Environmental Adaptation

Integrative Zoology, EarlyView.
A high‐quality chromosome‐level reference genome was constructed for Hucho bleekeri. Population structure and environmental adaptation of Hucho species were revealed by whole‐genome resequencing. ABSTRACT Salmonidae represents an important family in the study of genome evolution following genome duplication.
Yeyu Chen, Huanchao Yang, Zhao Liu, Xiaoyun Wu, Qinyao Wei, Yanling Chen, Jue Lin, Yi Yu, Quanyu Tu, Hua Li   +9 more
wiley   +1 more source