Results 101 to 110 of about 475,573 (366)

A Complementarity‐Based Approach to De Novo Binder Design

Advanced Science, EarlyView.
A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko, Valeriia Hatskovska, Murray Coles, Narges Aghaallaei, Natalia Pashkovskaia, Natalia Borbarán‐Bravo, Matteo Pilz, Philip Bucher, Mareike Volz, Joana Pereira, Marcus D. Hartmann, Ghazaleh Tabatabai, Judith Feucht, Stefan Liebau, Patrick Müller, Andrei N. Lupas, Julia Skokowa, Mohammad ElGamacy   +17 more
wiley   +1 more source

Prospects for a MERS-CoV spike vaccine

Expert Review of Vaccines, 2018
Introduction: Six years have passed since Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV), a newly emerging infectious virus, was first reported in 2012.
Yusen Zhou, Shibo Jiang, Lanying Du
doaj   +1 more source

MERS-CoV (Middle East Respiratory Syndrome Coronavirus) outside the Arabian Peninsula an One Health approach: Understanding the role of wildlife, livestock and human in the virus dynamic [PDF]

, 2016
One of the big paradoxes of the MERS-CoV epidemiology is the apparent lack of human cases in large parts Africa where the virus and an animal host, the dromedary camel, are present.
Akhmetsadykov, Nourlan, Ayelet, Gelagay, Baubekova, Almagul, Ben Bencheikh, M.N., Bourgarel, Mathieu, Boussini, H., Chevalier, Véronique, Chu, Daniel K.W., El Berbri, Ikhlass, Fassi-Fihri, Ouafaa, Faye, Bernard, Fekadu, G., Grosbois, Vladimir, Maher, W., Miguel, Eve, Peiris, Malik, Perera, Ranawaka A.P.M., Roche, Benjamin, Roger, François, Shimekit, D., Traoré, Amadou, Van Kerkhove, Maria D.   +21 more
core  

Determination of the Critical Exponents for the Isotropic-Nematic Phase Transition in a System of Long Rods on Two-dimensional Lattices: Universality of the Transition

, 2008
Monte Carlo simulations and finite-size scaling analysis have been carried out to study the critical behavior and universality for the isotropic-nematic phase transition in a system of long straight rigid rods of length $k$ ($k$-mers) on two-dimensional ...
A. J. Ramirez-Pastor, Binder K., D. A. Matoz-Fernandez, D. H. Linares, Fisher M. E., Flory P. J., Ghosh A., Kamieniarz G., Privman V., Selke W., Selke W., Tomé T., Vroege G. J.   +12 more
core   +1 more source

Alignment-free sequence comparison with spaced k-mers [PDF]

, 2013
Alignment-free methods are increasingly used for genome analysis and phylogeny reconstruction since they circumvent various difficulties of traditional approaches that rely on multiple sequence alignments.
, Boden, Marcus, Horwege, Sebastian, Leimeister, Chris, Lindner, Sebastian, Morgenstern, Burkhard   +5 more
core   +1 more source

deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

Advanced Science, EarlyView.
DeepTFBS leverages deep learning to predict transcription factor binding sites across species, integrating multi‐task and transfer learning approaches to improve performance in data‐scarce scenarios. This study demonstrates enhanced accuracy in intra‐ and cross‐species prediction, revealing conserved regulatory patterns and functional variants.
Jingjing Zhai, Yuzhou Zhang, Chujun Zhang, Xiaotong Yin, Minggui Song, Chenglong Tang, Pengjun Ding, Zenglin Li, Chuang Ma   +8 more
wiley   +1 more source

Epidemics and Reforms: Experience of Saudi Arabia

Международная аналитика, 2020
Saudi Arabia is one of the key countries in the Middle East and the Arab-Muslim world. The processes developing in this country, determined by both internal and external factors, are directly related to the development of the surrounding geopolitical ...
G. G. Kosach
doaj   +1 more source

DiBELLA: Distributed long read to long read alignment [PDF]

, 2019
We present a parallel algorithm and scalable implementation for genome analysis, specifically the problem of finding overlaps and alignments for data from "third generation" long read sequencers [29]. While long sequences of DNA offer enormous advantages
Buluç, A, Ellis, M, Guidi, G, Oliker, L, Yelick, K   +4 more
core   +2 more sources

Corona Viruses: A Review on SARS, MERS and COVID-19

Microbiology Insights, 2021
After the outbreak of SARS and MERS, the world is now in the grip of another viral disease named COVID-19 caused by a beta Coronavirus – SARS COV-2 which appears to be the only one with a pandemic potential. The case of COVID-19 was reported in the Hubei
Nihala Naseefa Chathappady House, Sheeba Palissery, H. Sebastian   +2 more
semanticscholar   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source