Results 21 to 30 of about 3,412 (160)

NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS [PDF]

open access: yesBulletin of Pharmaceutical Sciences. Assiut University, 1994
The possible involvement of the synclinal conformation of mescaline with phencyclidine (PCP)-receptors has promoted the synthesis of certain novel structural hybrids of mescaline with PCP-analogs.
R. Shafik   +3 more
doaj   +1 more source

Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines

open access: yesFrontiers in Pharmacology, 2022
3,4,5-Trimethoxyphenethylamine (mescaline) is a psychedelic alkaloid found in peyote cactus. Related 4-alkoxy-3,5-dimethoxy-substituted phenethylamines (scalines) and amphetamines (3C-scalines) are reported to induce similarly potent psychedelic effects ...
Karolina E. Kolaczynska   +5 more
doaj   +1 more source

Hofmann vs. Paracelsus: Do Psychedelics Defy the Basics of Toxicology?—A Systematic Review of the Main Ergolamines, Simple Tryptamines, and Phenylethylamines

open access: yesToxics, 2023
Psychedelics are experiencing a strong renaissance and will soon be incorporated into clinical practice. However, there is uncertainty about how much harm they can cause at what doses.
Luis Alberto Henríquez-Hernández   +3 more
doaj   +1 more source

Psychedelic Therapy: A Primer for Primary Care Clinicians—Mescaline

open access: yes
Background: Mescaline (3,4,5-trimethoxyphenethylamine) is a classic serotonergic psychedelic with a history of indigenous ceremonial use. There is renewed scientific interest in mescaline due to the potential psychiatric benefits of psychedelic-assisted ...
Owen S. Muir   +5 more
core   +6 more sources

Psychedelics: A new era of treatment?

open access: yesEuropean Psychiatry, 2021
Introduction Psychedelics - including LSD (lysergic acid diethylamide), psilocybin, DMT (N, N-dimethyltryptamine), ayahuasca and mescaline - have an ancient history across various civilizations.
S. Torres
doaj   +1 more source

‐Diformylmescaline: A novel analogue of mescaline detected in Queensland

open access: yes, 2022
N,N-Diformylmescaline, a novel analogue of mescaline, has recently been detected in Australia in two unrelated seizures. To confirm the identification, a three-step synthesis from 3,4,5-trimethoxyphenylacetic acid was devised.
Urs D. Wermuth   +11 more
core   +1 more source

Dans l’ivresse mescalinique : Jean-Paul Sartre, clinicien de l’imagination ?

open access: yesCygne Noir, 2021
Dans quel cadre culturel et théorique la fameuse expérimentation de mescaline par Jean-Paul Sartre s’est-elle déroulée ? En répondant à cette question, nous mettons au jour comment un modèle psychopathologique fonctionne à plein régime dans les « Notes ...
Gautier Dassonneville
doaj   +1 more source

The suitability of zebrafish (danio rerio) as an optimal organism to further investigate the associated schizophrenia-like phenotype

open access: yesEuropean Psychiatry, 2023
Introduction Zebrafish (Danio rerio) has evolved over the years as a preferred organism due to its vast repertoire in research fields that mimic a targeted phenotype, particularly behavioral typologies and specific attributes comparable to murine models
I. B. Nita   +5 more
doaj   +1 more source

Unraveling the In Vitro Toxicity Profile of Psychedelic 2C Phenethylamines and Their N-Benzylphenethylamine (NBOMe) Analogues

open access: yesPharmaceuticals, 2023
Mescaline derivative (2C phenethylamines) drugs have been modified by the introduction of a N-2-methoxybenzyl group to originate a new series of compounds with recognized and potent psychedelic effects, the NBOMe-drugs.
Daniel Martins   +9 more
doaj   +1 more source

Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?

open access: yesFrontiers in Pharmacology, 2021
Psychostimulants are used therapeutically and for illegal recreational purposes. Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). According to their physicochemical properties, some
Ole Jensen   +3 more
doaj   +1 more source

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