Results 41 to 50 of about 26,579 (349)

Late-onset Parkinsonism in NFκB/c-Rel-deficient mice [PDF]

, 2012
Activation of the nuclear factor κB/c-Rel can increase neuronal resilience to pathological noxae by regulating the expression of pro-survival manganese superoxide dismutase (MnSOD, now known as SOD2) and Bcl-xL genes. We show here that c-Rel-deficient (c-
Alghisi, M, Baiguera, C, Bellucci, A, Benarese, M, Bertini, G, DE LUCA, MARIA ANTONIETTA, Fabene, Pf, FRAU, LUCIA, Ingrassia, R, Liou, Hc, MORELLI, MICAELA, Pellitteri, M, PINNA, ANNALISA, Pizzi, M., Porrini, V, Sigala, S, Spano, Pf, Spillantini, Mg   +17 more
core   +3 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity [PDF]

, 2008
In the previous studies, we showed that strong Fgf8 signaling activates the Ras-ERK pathway to induce cerebellum. Here, we show importance of negative regulation of this pathway.
Asuka Suzuki-Hirano, Harukazu Nakamura, Tatsuya Sato   +2 more
core   +1 more source

The Diverse Neuromuscular Spectrum of VPS13A Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective VPS13A disease (chorea‐acanthocytosis) is a rare neurodegenerative disorder caused by biallelic variants in VPS13A, typically presenting with hyperkinetic movement disorders, while neuromuscular signs are often mild. The aim of the project was to investigate the frequency and severity of neuromuscular impairment in VPS13A disease ...
Anne Buchberger, Evamaria Riedel, Marie Hackenberg, Alexander Mensch, Stefanie Beck‐Woedl, Joohyun Park, Tobias B. Haack, Bernhard Haslinger, Jan Kirschke, Holger Prokisch, Andreas Hermann, Christian Mawrin, Adrian Danek, Benedikt Schoser, Kevin Peikert, Marcus Deschauer, Isabell Cordts   +16 more
wiley   +1 more source

Birth asphyxia as the major complication in newborns: Moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care [PDF]

, 2011
Perinatal Asphyxia—oxygen deficit at delivery—can lead to severe hypoxic ischaemic organ damage in newborns followed by a fatal outcome or severe life-long pathologies.
CEBIOGLU M, GOLUBNITSCHAJA O, HERRERA-MARSCHITZ M, MORELLI M, YEGHIAZARYAN K   +4 more
core   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Eyes as Gateways for Environmental Light to the Substantia Nigra: Relevance in Parkinson’s Disease

The Scientific World Journal, 2014
Recent data indicates that prolonged bright light exposure of rats induces production of neuromelanin and reduction of tyrosine hydroxylase positive neurons in the substantia nigra. This effect was the result of direct light reaching the substantia nigra
Stefania Romeo, Daniela Di Camillo, Alessandra Splendiani, Marta Capannolo, Cristina Rocchi, Gabriella Aloisi, Irene Fasciani, Giovanni U. Corsini, Eugenio Scarnati, Luca Lozzi, Roberto Maggio   +10 more
doaj   +1 more source

Mating signals indicating sexual receptiveness induce unique spatio-temporal EEG theta patterns in an anuran species. [PDF]

PLoS ONE, 2012
Female mate choice is of importance for individual fitness as well as a determining factor in genetic diversity and speciation. Nevertheless relatively little is known about how females process information acquired from males during mate selection.
Guangzhan Fang, Ping Yang, Jianguo Cui, Dezhong Yao, Steven E Brauth, Yezhong Tang   +5 more
doaj   +1 more source

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

Alterations in neural crest migration by a monoclonal antibody that affects cell adhesion [PDF]

, 1985
The possible role of a 140-kD cell surface complex in neural crest adhesion and migration was examined using a monoclonal antibody JG22, first described by Greve and Gottlieb (1982, J. Cell. Biochem. 18:221-229).
Bronner-Fraser, Marianne
core   +1 more source