Results 111 to 120 of about 5,745,585 (307)

Plasma-activated polymer films for mesenchymal stem cell differentiation [PDF]

, 2014
Polyetheretherketone (PEEK) is a biomaterial utilized for spine, orthopedic and trauma implants. Its inertness prevents osseointegration, so that coatings with titanium or hydroxyapatite are required for load-bearing PEEK implants.
Waser-Althaus, Jasmin
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Efficacy of autologous mesenchymal stem cell transplantation in patients with liver cirrhosis

The Turkish Journal of Gastroenterology, 2015
Background/Aims: Because of several limitations and complications of liver transplantation, new alternative treatment modalities are required for patients with liver cirrhosis.
Murat Kantarcıoğlu, Hakan Demirci, Ferit Avcu, Yıldırım Karslıoğlu, Mustafa Alpaslan Babayiğit, Bülent Karaman, Kadir Öztürk, Hasan Gürel, Meral Akdoğan Kayhan, Sabite Kaçar, Ayhan Kubar, Gürol Öksüzoğlu, Ali Uğur Ural, Sait Bağcı   +13 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Characterisation of human mesenchymal stem cell metabolism during proliferation and differentiation. [PDF]

, 2010
PhDMesenchymal stem cells (MSCs) have the ability to differentiate towards cartilage, bone, fat and muscle, and therefore have great therapeutic potential.
Pattappa, Girish
core   +3 more sources

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

A genomics approach in determining nanotopographical effects on MSC phenotype [PDF]

, 2013
Topography and its effects on cell adhesion, morphology, growth and differentiation are well documented. Thus, current advances with the use of nanotopographies offer promising results in the field of regenerative medicine.
Tsimbouri, P.M., Herzyk, Pawel, Tsimbouri, Penelope M., Murawski, Kate, Hamilton, Graham, Oreffo, Richard O.C., Gadegaard, Nikolaj, Dalby, Matthew J.   +7 more
core   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

A case series on safety and tolerability of human umbilical cord-derived mesenchymal stem cells on patients in Malaysia

SAGE Open Medical Case Reports
Umbilical cord-derived mesenchymal stem cells for regenerative therapy are a promising treatment option for chronic illnesses. Umbilical cord-derived mesenchymal stem cells offer several advantages over other sources, which makes them an attractive ...
Basmullah Yusof, Iqmaliza Kamal, Ka Man Lee, Siong Kiat Chai, Xia Lin Zuo, Manickam Ravichandran, Ke Xiang Ding, Neeraj Kumar Fuloria, Seng Kong Tham   +8 more
doaj   +1 more source