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Mesenchymal Stem Cell Mechanobiology
Current Osteoporosis Reports, 2010Bone marrow-derived multipotent stem and stromal cells (MSCs) are likely candidates for cell-based therapies for various conditions including skeletal disease. Advancement of these therapies will rely on an ability to identify, isolate, manipulate, and deliver stem cells in a safe and effective manner.
Alesha B, Castillo +1 more
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Biology of mesenchymal stem cells
Injury, 2005Mesenchymal stem cells are present in many human tissues and serve as a readily available source of undifferentiated cells being capable to form specific tissues like bone, cartilage, fat, muscle and tendon. They represent an attractive and promising field in tissue regeneration and engineering for treatment applications in a wide range of trauma and ...
Ippokratis, Pountos, Peter V, Giannoudis
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Proteome of mesenchymal stem cells
PROTEOMICS, 2007Abstract Proteomics has evolved, in recent years, into effective tools for basic and applied stem cell research, and has been extensively used to facilitate the identification of changes in signal transduction components, especially with regard to plasticity, proliferation, and differentiation.
Hye Won, Park +2 more
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Mesenchymal Autologous Stem Cells
World Neurosurgery, 2015The use of cell-based therapies for spinal cord injuries has recently gained prominence as a potential therapy or component of a combination strategy. Experimental and clinical studies have been performed using mesenchymal stem cell therapy to treat spinal cord injuries with encouraging results.
Asdrubal, Falavigna +1 more
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Annual Review of Cell and Developmental Biology, 2014
Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. One sees MSCs as the postnatal, self-renewing, and multipotent stem cells for the skeleton. This cell coincides with a specific type of bone marrow perivascular cell.
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Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. One sees MSCs as the postnatal, self-renewing, and multipotent stem cells for the skeleton. This cell coincides with a specific type of bone marrow perivascular cell.
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Journal of Orthopaedic Research, 1991
AbstractBone and cartilage formation in the embryo and repair and turnover in the adult involve the progeny of a small number of cells called mesenchymal stem cells. These cells divide, and their progeny become committed to a specific and distinctive phenotypic pathway, a lineage with discrete steps and, finally, end‐stage cells involved with ...
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AbstractBone and cartilage formation in the embryo and repair and turnover in the adult involve the progeny of a small number of cells called mesenchymal stem cells. These cells divide, and their progeny become committed to a specific and distinctive phenotypic pathway, a lineage with discrete steps and, finally, end‐stage cells involved with ...
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Circulating mesenchymal stem cells
The International Journal of Biochemistry & Cell Biology, 2004Mesenchymal precursor cells (MPCs) are multipotent cells capable of differentiating into various mesenchymal tissues, such as bone, cartilage, fat, tendon and muscle. They are present within both mesenchymal tissues and the bone marrow (BM). If marrow-derived MPCs are to have a role in repair and fibrosis of mesenchymal tissues, transit of these cells ...
C A, Roufosse +3 more
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Experimental Gerontology, 2005
Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem cells within a given pool ...
Christine, Fehrer, Günter, Lepperdinger
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Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem cells within a given pool ...
Christine, Fehrer, Günter, Lepperdinger
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Mesenchymal stem cell exosomes
Seminars in Cell & Developmental Biology, 2015MSCs are an extensively used cell type in clinical trials today. The initial rationale for their clinical testing was based on their differentiation potential. However, the lack of correlation between functional improvement and cell engraftment or differentiation at the site of injury has led to the proposal that MSCs exert their effects not through ...
Ruenn Chai, Lai +2 more
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Aging of mesenchymal stem cells
Ageing Research Reviews, 2006The role of adult mesenchymal stem cells (MSC) in tissue maintenance and regeneration has received significant attention of late. Questions arise to what extent these cells are either subject to, or causes of aging; whether age-related changes in these cells are due to intrinsic factors or induced by the somatic environment.
Sebastian, Sethe +2 more
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