Results 221 to 230 of about 556,462 (362)

Synchronizing the Osteochondral Regeneration Process through Spatial Patterning of Stable and Hypertrophic Cartilage Organoids

open access: yesAdvanced Materials, EarlyView.
Zonated osteochondral assembloid implants are engineered through scaffold‐free spatial assembly of induced pluripotent stem cell (iPSC)‐derived chondrocyte organoids and periosteum‐derived osteogenic organoids. Implanted into full‐thickness rat osteochondral defects, they promote hyaline‐like cartilage repair, support subchondral bone formation with ...
Liuqi Peng   +3 more
wiley   +1 more source

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

open access: yesAdvanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung   +6 more
wiley   +1 more source

Sea Urchin‐Inspired Immuno‐Instructive Ionic Flow Drives MSCs‐Macrophage Communication to Promote Bone Regeneration

open access: yesAdvanced Materials, EarlyView.
ABSTRACT Bone tissue regeneration is a complex physiological process dependent on the spatiotemporal coordination of immune cells and stem cells. Conventional research primarily elucidates the mechanism through which materials facilitate bone formation by initially modulating macrophages and subsequently encouraging the osteogenic differentiation of ...
Yang Lu   +11 more
wiley   +1 more source

Hierarchical therapeutic potential in the mesenchymal stem cell landscape. [PDF]

open access: yesJ Transl Med
Pearl JR   +9 more
europepmc   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

open access: yesAdvanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike   +3 more
wiley   +1 more source

Bioelectrical Interfaces Beyond Excitable Cells: Cancer, Aging, and Gene Expression Modulation

open access: yesAdvanced Materials Interfaces, EarlyView.
ABSTRACT The investigation of biological conductivity has evolved from its classical foundation based on ionic fluxes underpinning cardiac and neuronal excitability to a multifaceted regulator of cellular physiology. Traditional approaches for probing electrical events in living matter focused largely on action potentials recording.
Paolo Cadinu   +14 more
wiley   +1 more source

Influence of commonly used pharmaceutical agents on equine bone marrow-derived mesenchymal stem cell viability [PDF]

open access: yes, 2017
Ankrum   +32 more
core   +2 more sources

3D Printed Multimaterial Microfluidic Transistors

open access: yesAdvanced Materials Technologies, EarlyView.
We introduce a biocompatible, high resolution photopolymer resin that closely mimics the Young's Modulus (elasticity) and reversible stretchability (no hysteresis) of poly(dimethylsiloxane) (PDMS), enabling the fabrication of microfluidic transistors (i.e., microvalves capable of proportional amplification) by multimaterial stereolithography (mSLA ...
Alireza Ahmadianyazdi   +7 more
wiley   +1 more source

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