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Mesenchymal stem cells

Archives of Medical Research, 2003
It has become clear that adult mammalian bone marrow contains not one but two ostensibly discrete populations of adult stem cells. The first and by far the most fully characterized are the hematopoietic stem cells responsible for maintaining lifelong production of blood cells.
Brenton, Short   +4 more
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Mesenchymal Stem Cell Mechanobiology

Current Osteoporosis Reports, 2010
Bone marrow-derived multipotent stem and stromal cells (MSCs) are likely candidates for cell-based therapies for various conditions including skeletal disease. Advancement of these therapies will rely on an ability to identify, isolate, manipulate, and deliver stem cells in a safe and effective manner.
Alesha B, Castillo   +1 more
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Circulating mesenchymal stem cells

The International Journal of Biochemistry & Cell Biology, 2004
Mesenchymal precursor cells (MPCs) are multipotent cells capable of differentiating into various mesenchymal tissues, such as bone, cartilage, fat, tendon and muscle. They are present within both mesenchymal tissues and the bone marrow (BM). If marrow-derived MPCs are to have a role in repair and fibrosis of mesenchymal tissues, transit of these cells ...
C A, Roufosse   +3 more
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Mesenchymal Autologous Stem Cells

World Neurosurgery, 2015
The use of cell-based therapies for spinal cord injuries has recently gained prominence as a potential therapy or component of a combination strategy. Experimental and clinical studies have been performed using mesenchymal stem cell therapy to treat spinal cord injuries with encouraging results.
Asdrubal, Falavigna   +1 more
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Mesenchymal Stem Cells

Journal of Orthopaedic Research, 1991
AbstractBone and cartilage formation in the embryo and repair and turnover in the adult involve the progeny of a small number of cells called mesenchymal stem cells. These cells divide, and their progeny become committed to a specific and distinctive phenotypic pathway, a lineage with discrete steps and, finally, end‐stage cells involved with ...
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Mesenchymal stem cell aging

Experimental Gerontology, 2005
Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem cells within a given pool ...
Christine, Fehrer, Günter, Lepperdinger
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“Mesenchymal” Stem Cells

Annual Review of Cell and Developmental Biology, 2014
Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. One sees MSCs as the postnatal, self-renewing, and multipotent stem cells for the skeleton. This cell coincides with a specific type of bone marrow perivascular cell.
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Mesenchymal stem cell exosomes

Seminars in Cell & Developmental Biology, 2015
MSCs are an extensively used cell type in clinical trials today. The initial rationale for their clinical testing was based on their differentiation potential. However, the lack of correlation between functional improvement and cell engraftment or differentiation at the site of injury has led to the proposal that MSCs exert their effects not through ...
Ruenn Chai, Lai   +2 more
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