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Mesenchymal stem cell exosomes
Seminars in Cell & Developmental Biology, 2015MSCs are an extensively used cell type in clinical trials today. The initial rationale for their clinical testing was based on their differentiation potential. However, the lack of correlation between functional improvement and cell engraftment or differentiation at the site of injury has led to the proposal that MSCs exert their effects not through ...
Ruenn Chai, Lai +2 more
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Mesenchymal stem cells in osteoarthritis
Current Opinion in Rheumatology, 2004Accumulating evidence indicates that every tissue contains stem cells. Our understanding of the biology of stem cells reveals that these cell populations have a critical role in the homeostasis and repair of tissues. Besides the local stem cell niches, additional compartments in the body such as the bone marrow may serve as reservoirs for stem cell ...
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Cryobanking Mesenchymal Stem Cells
2017Cryopreservation and storage of culture-expanded mesenchymal stem cells (MSCs) is essential for a biobank to maintain a collection of cell lines for research and clinical use. Optimization of cryopreservation protocols and methods to minimize damage to cells during freezing and thawing is critical to ensure reliable availability of viable cells ...
Andrés, Pavón +3 more
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Perivascular cells as mesenchymal stem cells
Expert Opinion on Biological Therapy, 2010Mesenchymal stem cells are multipotent adult stem cell populations that have broad differentiation plasticity and immunosuppressive potential that render them of great importance in cell-based therapies. They are identified by in vitro characteristics based on their differentiation potential for clinical approaches while their biological properties and
Feng, Jifan +2 more
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Mesenchymal Stem/Stromal Cells: MESENCHYMAL STEM/STROMAL CELLS
Cytotherapy, 2023E. Heyman +3 more
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Mesenchymal Stem Cells in Cancer
Stem Cell Reviews, 2008It is becoming increasingly evident that stromal cells such as macrophages, mast cells, adipocytes and mesenchymal cells associated with tumors significantly contribute to tumorigenesis. Some types of cancer indeed profoundly rely on extrinsic signals afforded by infiltrating or neighbouring cells for survival, proliferation and dissemination.
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Mesenchymal Stem Cell Engineering
2018Mesenchymal stem cells (MSC) are multipotent stem cells that display the capacity to generate the tissue in which they reside. MSC have been used as progenitor cells to engineer cartilage implants that can be used to repair chondral and osteochondral lesions, or as trophic producers of bioactive factors to initiate endogenous regenerative activities in
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Mesenchymal Stem Cells and Haematopoietic Stem Cell Culture
2012Haematopoietic stem cell (HSC) transplantation is an established cell-based therapy for a number of haematological malignancies and immunodeficiency diseases. However, the limited number of HSC from umbilical cord blood (UCB) limits the efficacy of transplants from this source.
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