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Mesenchymal Stem Cells in Allogeneic Transplantation
2003Graft failure and graft-vs-host disease (GVHD) remain significant obstacles to successful outcome in patients undergoing allogeneic hematopoietic stem cell transplantation. This chapter will introduce a novel cellular therapy, which may address these problems, particularly in high risk patients such as those receiving marginal numbers of hematopoietic ...
Omer N. Koç, Stanton L. Gerson
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Stem cell transplantation and mesenchymal cells to treat autoimmune diseases
La Presse Médicale, 2016Since the start of the international stem cell transplantation project in 1997, over 2000 patients have received a haematopoietic stem cell transplant (HSCT), mostly autologous, as treatment for a severe autoimmune disease, the majority being multiple sclerosis (MS), systemic sclerosis (SSc) and Crohn's disease. There was an overall 85% 5-year survival
Tyndall A, van Laar JM
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Mesenchymal Stem Cells and Transplantation Tolerance
2017Transplantation tolerance meaning stable graft function without rejection episodes in the absence of immunosuppressive drugs while maintaining third-party immune response intact is still not achieved in clinic. Mesenchymal stem cells (MSCs) are believed to fulfill this dream of tolerance due to their immunomodulatory and tolerogenic properties.
Hargovind L. Trivedi, Aruna V. Vanikar
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Cell transplantation: Differential effects of myoblasts and mesenchymal stem cells
International Journal of Cardiology, 2006Cellular transplantation has emerged as a novel therapeutic option for treatment of ventricular dysfunction. Both skeletal myoblasts (SM) and mesenchymal stem cells (MSC) have been proposed as ideal cell for this aim. The aim of this study is to compare the efficacy of these cells in improving ventricular function and to evaluate the different ...
L C, Guarita-Souza +11 more
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Mesenchymal Stem Cells In Islet Transplantion
2013Type 1 diabetes mellitus (T1DM) is a chronic disorder of glucose metabolism due to autoimmune destruction of insulin producing β-cells. Although insulin therapy is the standard treatment for T1DM, islet transplantation, which has emerged as an alternative to insulin injection, offers a more physiologic means of glycemic control.
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Co-transplantation of mesenchymal stem cells for efficient spermatogonial stem cell transplantation
2017Spermatogonial stem cell transplantation (SSCT) is a promising fertility preservation technique for pre-pubertal cancer patients. However, transplanting only SSCs results in low colonization efficiency in mice. This might be due to a deficient SSC niche.
Kadam, Prashant +3 more
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Clinical Consideration for Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation
Transplantation, 2013Kang-Hsi, Wu +4 more
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Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation
2011Peiman Hematti +2 more
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