Results 51 to 60 of about 5,254,849 (303)

Testosterone Propionate Promotes Proliferation and Viability of Bone Marrow Mesenchymal Stem Cells while Preserving Their Characteristics and Inducing Their Anti-Cancer Efficacy

Balkan Medical Journal, 2023
Background: Various studies have reported the effects of testosterone on different cell types, yet bone marrow-derived mesenchymal stem cells’ cellular responses to testosterone remain unknown. Aims: To investigate the effects of testosterone propionate,
Başak Aru, Tuba Akdeniz, Hüsniye Dağdeviren, Gizem Gürel, Gülderen Yanıkkaya Demirel   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy [PDF]

, 2014
Cell-based regenerative therapies, based on in vitro propagation of stem cells, offer tremendous hope to many individuals suffering from degenerative diseases that were previously deemed untreatable.
Haque, N., Rahman, M. T., Alabsi, A. M., Abu Kasim, N. H.   +3 more
core   +1 more source

Co-transplantation of Human Fetal Mesenchymal and Hematopoietic Stem Cells in Type 1 Diabetic Mice Model

Frontiers in Endocrinology, 2019
Introduction: Cell therapy can overcome the limitation of conventional treatments (including different medications and β cell replacement) for type 1 diabetes.
Babak Arjmand, Babak Arjmand, Parisa Goodarzi, Hamid Reza Aghayan, Moloud Payab, Fakher Rahim, Sepideh Alavi-Moghadam, Fereshteh Mohamadi-jahani, Bagher Larijani   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer [PDF]

, 2012
In recent years, the cancer stem cell hypothesis has emerged as a compelling but controversial model of cancer progression. Contrary to the clonal evolution model, the cancer stem cell hypothesis postulates that, akin to normal tissues, tumours are ...
Dunning-Foreman, NL
core  

Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]

, 2012
Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Ruiz-Heinrich, Lourdes, Peröbner, Iris, Capovilla, Simon, Neth, Peter, Fernsebner, Katharina, Lechner, F., Jochum, M., Neth, P., Kolben, Thomas, Geissler, Claudia, Fernsebner, K., Geissler, C., Perobner, I., Peroebner, Iris, Jochum, Marianne, Lechner, Felix, Ruiz-Heinrich, L., Kolben, T., Capovilla, S.   +18 more
core   +1 more source

Standardization and quality assessment for clinical grade mesenchymal stem cells from human adipose tissue

Hematology, Transfusion and Cell Therapy, 2019
Background: Mesenchymal stem cells have immense potential in stem cell-based therapies, however there is a pre-requisite to develop a curative cell dose. Adipose tissue-derived mesenchymal stem cells are promising mainly due to their potential abundance,
Tanya Debnath, Lakshmi Kiran Chelluri
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Mesenchymal Stem Cells Promote Oligodendroglial Differentiation in Hippocampal Slice Cultures [PDF]

, 2009
We have previously shown that soluble factors derived from mesenchymal stem cells (MSCs) induce oligodendrogenic fate and differentiation in adult rat neural progenitors (NPCs) in vitro.
Aigner, L., Götz, Magdalena, Blümcke, I., Berninger, Benedikt, Siebzehnrubl, Florian, Couillard-Despres, Sebastien, Bogdahn, Ulrich, Caioni, Massimiliano, Kandasamy, M., Pöhler, A.M., Couillard-Despres, S., Berninger, B., Weidner, N., Aigner, Ludwig, Götz, M., Siebzehnrubl, F.A., Bogdahn, U., Weidner, Norbert, Sandner, B., Poehler, Anne-Maria, Sandner, Beatrice, Goetz, Magdalena, Rivera, Francisco J., Caioni, M., Bluemcke, Ingmar, Siebzehnrubl, Florian A., Kandasamy, Mahesh, Rivera, F.J.   +27 more
core   +1 more source