Results 41 to 50 of about 5,254,849 (303)

GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells

Haematologica, 2014
The bone marrow microenvironment comprises multiple cell niches derived from bone marrow mesenchymal stem cells. However, the molecular mechanism of bone marrow mesenchymal stem cell differentiation is poorly understood. The transcription factor GATA2 is
Mayumi Kamata, Yoko Okitsu, Tohru Fujiwara, Masahiko Kanehira, Shinji Nakajima, Taro Takahashi, Ai Inoue, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae   +12 more
doaj   +1 more source

Dental mesenchymal stem cells [PDF]

Development, 2016
Mammalian teeth harbour mesenchymal stem cells (MSCs), which contribute to tooth growth and repair. These dental MSCs possess many in vitro features of bone marrow-derived MSCs, including clonogenicity, expression of certain markers, and following stimulation, differentiation into cells that have the characteristics of osteoblasts, chondrocytes and ...
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

In vitro exploration of the therapeutic potential of mesenchymal stem cell conditioned medium in endometriosis treatment by targeting apoptosis and cellular migration

International Journal of Reproductive BioMedicine
Background: Endometriosis, a common gynecological disorder involving ectopic endometrial tissue, leads to infertility and chronic pain. Dysregulated apoptosis and abnormal cell migration are key pathological features. Given current treatment limitations,
Hassan Hedayatnia, Naser Kalhor
doaj   +1 more source

Mesenchymal Stem Cells Immunosuppressed IL-22 in Patients with Immune Thrombocytopenia via Soluble Cellular Factors

Journal of Immunology Research, 2015
Mesenchymal stem cells are immunoregulation cells. IL-22 plays an important role in the pathogenesis of immune thrombocytopenia. However, the effects of mesenchymal stem cells on IL-22 production in patients with immune thrombocytopenia remain unclear ...
Mei Wu, Hongfeng Ge, Shue Li, Hailiang Chu, Shili Yang, Xiaoxing Sun, Zhenxia Zhou, Xiongpeng Zhu   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The in vitro plasticity of hair follicle dermal and mesenchymal stem cells [PDF]

, 2008
Stem cells from the hair follicle are an easily accessible population of cells that have a broad in vitro developmental capabilities and potential for autologous replacement of damaged adult tissue.
Emmerson, Robert
core  

The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. [PDF]

, 2011
BACKGROUND: No treatments are currently available that slow, stop, or reverse disease progression in established multiple sclerosis (MS). The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) trial tests the safety and feasibility of treatment with a
Kolappan, Madhan, Thomas, David L, Andrew W Michell, Altmann, Daniel R., Richardson, Karen, Wheeler-Kingshott, Claudia AM, Karen Richardson, Thompson, Alan J., Shi L Luan, David L Thomas, Tozer, Daniel J, Webber, Daniel J., Rebecca S Samson, Siddharthan Chandran, Xiao-Ling He, Crawley, Charles, Compston, Alastair, Du, Ming-Qing, Alan J Thompson, Michell, Andrew W, Webber, Daniel J, Peter Connick, Kelly Barber, Barber, Kelly, Ming-Qing Du, Thompson, Alan J, Michael A Scott, Claudia AM Wheeler-Kingshott, Charles Crawley, Madhan Kolappan, Alastair Compston, Thomas, David L., Patani, Rickie, Wheeler-Kingshott, Claudia A. M., Tozer, Daniel J., Miller, David H, Scott, Michael A., Daniel J Tozer, He, Xiao-Ling, Miller, David H., Luan, Shi L, Daniel J Webber, Rickie Patani, Altmann, Daniel R, Samson, Rebecca S, David H Miller, Scott, Michael A, Chandran, Siddharthan, Luan, Shi L., Daniel R Altmann, Connick, Peter, Samson, Rebecca S., Michell, Andrew W., Chandran Siddharthan, Kolappan Madhan, Luan Shi L, Miller David H, Crawley Charles, Richardson Karen, Wheeler-Kingshott Claudia AM, Scott Michael A, Thompson Alan J, Webber Daniel J, Du Ming-Qing, Compston Alastair, Patani Rickie, Altmann Daniel R, Samson Rebecca S, He Xiao-Ling, Connick Peter, Tozer Daniel J, Michell Andrew W, Barber Kelly, Thomas David L   +73 more
core   +4 more sources

Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches

Frontiers in Medicine
The inability to get or sustain an erection strong enough for fulfilling sexual performance is the hallmark of the common disorder known as erectile dysfunction (ED). It mostly affects a significant percentage of men worldwide, particularly those aged 40
Xiaoliang Fu, Azar Sheikholeslami, Ulanbek Zhanbyrbekuly, Faezeh Davoodi Asl, Nadiar M. Mussin, Hoda Fazaeli, Karim Daniyalov, Nader Tanideh, Nader Tanideh, Nader Tanideh, Mahdi Mahdipour, Mahdi Mahdipour, Madina A. Kurmanalina, Amin Tamadon, Amin Tamadon, Amin Tamadon   +15 more
doaj   +1 more source

Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1

Haematologica, 2009
Background Conventionally, mesenchymal stem cells are functionally isolated from primary tissue based on their capacity to adhere to a plastic surface. This isolation procedure is hampered by the unpredictable influence of co-cultured hematopoietic and ...
Venkata Lokesh Battula, Sabrina Treml, Petra M. Bareiss, Friederike Gieseke, Helene Roelofs, Peter de Zwart, Ingo Müller, Bernhard Schewe, Thomas Skutella, Willem E. Fibbe, Lothar Kanz, Hans-Jörg Bühring   +11 more
doaj   +1 more source