Results 91 to 100 of about 4,624,864 (302)

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Moser, C., Huss, R., Moosmann, S., Hutter, J., Krombach, F.   +4 more
core   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Platelet lysate as a serum substitute for 2D static and 3D perfusion culture of stromal vascular fraction cells from human adipose tissue [PDF]

, 2009
Fetal bovine serum (FBS) and fibroblast growth factor (FGF)-2 are key supplements for the culture of stromal vascular fraction (SVF) cells from adipose tissue, both for typical monolayer (2D) expansion and for streamlined generation of osteogenic ...
Alini, Mauro, Verrier, Sophie, Droeser, Raoul, Bocelli-Tyndall, Chiara, Davenport, Michael, Martin, Ivan, Scherberich, Arnaud, Müller, Andreas M., Schaefer, Dirk J.   +8 more
core  

The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. [PDF]

, 2011
BACKGROUND: No treatments are currently available that slow, stop, or reverse disease progression in established multiple sclerosis (MS). The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) trial tests the safety and feasibility of treatment with a
Kolappan, Madhan, Thomas, David L, Andrew W Michell, Altmann, Daniel R., Richardson, Karen, Wheeler-Kingshott, Claudia AM, Karen Richardson, Thompson, Alan J., Shi L Luan, David L Thomas, Tozer, Daniel J, Webber, Daniel J., Rebecca S Samson, Siddharthan Chandran, Xiao-Ling He, Crawley, Charles, Compston, Alastair, Du, Ming-Qing, Alan J Thompson, Michell, Andrew W, Webber, Daniel J, Peter Connick, Kelly Barber, Barber, Kelly, Ming-Qing Du, Thompson, Alan J, Michael A Scott, Claudia AM Wheeler-Kingshott, Charles Crawley, Madhan Kolappan, Alastair Compston, Thomas, David L., Patani, Rickie, Wheeler-Kingshott, Claudia A. M., Tozer, Daniel J., Miller, David H, Scott, Michael A., Daniel J Tozer, He, Xiao-Ling, Miller, David H., Luan, Shi L, Daniel J Webber, Rickie Patani, Altmann, Daniel R, Samson, Rebecca S, David H Miller, Scott, Michael A, Chandran, Siddharthan, Luan, Shi L., Daniel R Altmann, Connick, Peter, Samson, Rebecca S., Michell, Andrew W., Chandran Siddharthan, Kolappan Madhan, Luan Shi L, Miller David H, Crawley Charles, Richardson Karen, Wheeler-Kingshott Claudia AM, Scott Michael A, Thompson Alan J, Webber Daniel J, Du Ming-Qing, Compston Alastair, Patani Rickie, Altmann Daniel R, Samson Rebecca S, He Xiao-Ling, Connick Peter, Tozer Daniel J, Michell Andrew W, Barber Kelly, Thomas David L   +73 more
core   +4 more sources

In vitro and in vivo characterization of murine bone marrow stromal stem cells: self renewal, differentiation, tumorigenic potential [PDF]

, 2009
The use of adult stem cells for applications such as tissue engineering and gene therapy is one of the major challenge approaches of regenerative medicine. In the field of adult stem cells, bone marrow stromal cells (BMSCs) are very promising candidates.
Esposito, Maria Teresa
core   +1 more source

Gene-expression and in vitro function of mesenchymal stromal cells are affected in juvenile myelomonocytic leukemia

Haematologica, 2015
An aberrant interaction between hematopoietic stem cells and mesenchymal stromal cells has been linked to disease and shown to contribute to the pathophysiology of hematologic malignancies in murine models.
Friso G.J. Calkoen, Carly Vervat, Else Eising, Lisanne S. Vijfhuizen, Peter-Bram A.C. ‘t Hoen, Marry M. van den Heuvel-Eibrink, R. Maarten Egeler, Maarten J.D. van Tol, Lynne M. Ball   +8 more
doaj   +1 more source

Mesenchymal Stromal Cells: New Directions [PDF]

Cell Stem Cell, 2012
Research into mesenchymal stromal/stem cells (MSCs) has been particularly exciting in the past five years. Our understanding of mechanisms of MSC-mediated tissue regeneration has undergone considerable evolution. Recent investigation of the primary in situ counterpart of cultured MSCs has led to fresh insights into MSC physiology and its role in the ...
openaire   +3 more sources

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation [PDF]

, 2012
Chronic graft-versus-host disease (cGVHD) is a complication after minor antigen mismatched bone marrow transplantation (BMT) characterized by an autoimmune-type reaction in various organs.
Yumi Matsuzaki, Yoko Ogawa, Shigeto Shimmura, Yo Mabuchi, Sadafumi Suzuki, Yutaka Kawakami, Shinichiro Okamoto, Hideyuki Okano, Takaaki Inaba, Satoru Morikawa, Saori Yaguchi, Kazuo Tsubota, Tomonori Yaguchi   +12 more
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