Results 81 to 90 of about 4,624,864 (302)
Mechanisms of mesenchymal stromal cell immunomodulation [PDF]
Immunology & Cell Biology, 2012 Multipotent mesenchymal stromal cells (MSCs) have generated considerable interest in the fields of regenerative medicine, cell therapy and immune modulation. Over the past 5 years, the initial observations that MSCs could enhance regeneration and modulate immune responses have been significantly advanced and we now have a clearer picture of the effects
openaire +3 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
A New Vision of Mesenchymal Stromal Cells [PDF]
Molecular Therapy, 2012 Although corneal grafts can restore vision to damaged and opaque eyes, these grafts, like any other transplanted tissue, may be rejected by the host so that blindness returns. In this issue of Molecular Therapy, Oh et al. report that the infusion of human mesenchymal stromal cells (MSCs) prevents allogeneic corneal rejection in a murine model and ...
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro +25 more
wiley +1 more source
Bone marrow mesenchymal stem cell niches and regenerative medicine [PDF]
, 2010 Mesenchymal progenitors are a powerful tool in regenerative medicine, but suffer from a rapid loss of differentiation potential during in vitro expansion.
Di Maggio, Nunzia
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, 2011 Mesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described.
Grange, Simon
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A New Bioactive Glass‐Based Hybrid Bioink With Enhanced Cell Viability and Antibacterial Properties
Advanced Healthcare Materials, EarlyView.Graphical illustration of the production and characterization process, demonstrating the multiple functions of the new hybrid gelatin methacryloyl‐silver‐bioactive glass (GAB) material. Created in https://BioRender.com. ABSTRACT Recent advances in three‐dimensional bioprinting (3DBP) technology enable the production of customized bone substitutes ...
Adam C. Marsh +14 more
wiley +1 more source
VEGF-expressing mesenchymal stem cells for improved angiogenesis in regenerative medicine : a bone tissue engineering approach [PDF]
, 2011 Rapid vascularization of tissue-engineered grafts is a major bottleneck in the development of regenerative medicine approaches. In order to overcome this limitation, we aimed to develop a bone tissue engineering strategy combining cell therapy with pro ...
Helmrich, Uta
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Haematologica, 2018 Mesenchymal stromal cells are involved in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia, but the underlying mechanisms are incompletely understood.
Stefanie Geyh +11 more
doaj +1 more source