Results 31 to 40 of about 60,618 (302)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The low-noise optimisation method for gearbox in consideration of operating conditions [PDF]

, 2014
This paper presents a comprehensive procedure to calculate the steady dynamic response and the noise radiation generated from a stepping-down gearbox.
Kang, J, Sun, W, Tao, Q, Zhou, J
core   +1 more source

Development of a multiblock procedure for automated generation of two-dimensional quadrilateral meshes of gear drives [PDF]

, 2020
This article describes a new multiblock procedure for automated generation of two-dimensional quadrilateral meshes of gear drives. The typical steps of the multiblock schemes have been investigated in depth to obtain a fast and simple way to mesh ...
Roda-Casanova, Victor, Sanchez-Marin, Francisco   +1 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Isothermal Elasto-hydrodynamic Lubrication Analysis of the Roller Enveloping End Face Meshing Worm Drive

Jixie chuandong, 2022
Based on the transmission theory of single roller enveloping end face meshing worm drive and isothermal elastohydrodynamic lubrication theory， and considering the influence of surface wavy roughness， a numerical analysis method is adopted to analyze the ...
Xiaolong Wang, Honghui Liao
doaj  

Generation principle and meshing characteristics of conjugate-curve circular arc gears

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2015
The generation principle and meshing characteristics of conjugate-curve circular arc gears, which is proposed based on the theory of conjugate curves, are studied in this paper.
Dong LIANG, Bingkui CHEN, Yan'e GAO, Yongqing ZHANG   +3 more
doaj   +1 more source

3D mesh calculations for covariant density functional theory [PDF]

Progress of Theoretical and Experimental Physics, 2015
3D mesh calculations for covariant density functional theory Y. Tanimura1,5,∗, K. Hagino1,2,3, and H. Z. Liang4 1Department of Physics, Tohoku University, Sendai 980-8578, Japan 2Research Center for Electron Photon Science, Tohoku University, 1-2-1 Mikamine, Sendai 982-0826, Japan 3National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo
Y. Tanimura, K. Hagino, H. Z. Liang
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Design, Meshing Characteristics and Stress Analysis of Cylindrical Gears with Curvilinear Tooth Profile [PDF]

, 2016
Curvilinear tooth gears are commonly produced on a face milling cutter and a hob cutter. However, this paper proposes a kind of curvilinear tooth gear which is processed by a parallel linkage with a single blade cutter. For the purpose of identifying the
Xingqiang Tan, Xuegang Zhang, Yongchun Xie   +2 more
core   +1 more source