Results 121 to 130 of about 65,698 (300)

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria.

, 2013
International audienceThe modulation of developmental biochemical pathways by mechanical cues is an emerging feature of animal development, but its evolutionary origins have not been explored. Here we show that a common mechanosensitive pathway involving
Dempsey, Nora M., Serman, Fanny, Givord, Dominique, Brunet, Anne-Christine, Brunet, Thibaut, Yanicostas, Constantin, Driquez, Benjamin, Henry, Laurent, Béalle, Gaëlle, Mitrossilis, Démosthène, Dumas-Bouchiat, Frédéric, Ahmadi, Padra, Plessis, Anne, Bouclet, Adrien, Le Roy, Damien, Farge, Emmanuel, Ménager, Christine   +16 more
core   +1 more source

Orbital Lymphatic Malformations Are Associated With Intracranial Vascular Anomalies

The Laryngoscope, EarlyView.
In this retrospective series, all seven patients with orbital lymphatic malformations had intracranial vascular anomalies consistent with cerebrofacial venous metameric syndrome and hotspot PIK3CA variants identified through tissue‐based sequencing. Five patients treated with alpelisib experienced symptom improvement within 6 months.
Kelsey A. Loy, Jennifer Siu, Clare Richardson, J. Nathaniel Perkins, Kaitlyn Zenner, Kevin Koo, Francisco Perez, James Bennett, Randall Bly, Danial K. Hallam, Amy Geddis, Jonathan A. Perkins   +11 more
wiley   +1 more source

Percentage of mitotic cells in ventral mesoderm population.

, 2013
A) Numbers of mitotic cells scored in 19 embryos from HH4-10. For HH4-5 embryos, cells in the lateral half of the mesoderm population from the posterior half the embryo are scored. For HH6-10 embryos, mesoderm cells in blood-island forming lateral region
Guojun Sheng (44470), Wei Weng (378422), Erike W. Sukowati (378423)   +2 more
core   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Mesoderm layer formation in Xenopus and Drosophila gastrulation

, 2011
During gastrulation, the mesoderm spreads out between ectoderm and endoderm to form a mesenchymal cell layer. Surprisingly the underlying principles of mesoderm layer formation are very similar in evolutionarily distant species like the fruit fly ...
Muller, H-Arno J., Rudolf Winklbauer, H-Arno J Müller, Winklbauer, Rudolf   +3 more
core   +1 more source

Evaluating Thiram‐Induced Embryotoxicity Using Integrated In Silico, In Vitro, and Transcriptomic Approaches

Environmental Toxicology, EarlyView.
ABSTRACT Long‐term exposure to low‐dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight‐of‐evidence computational model, which predicted 127 chemicals to be of high concern.
Chia‐Chi Ho, Chun‐Wei Tung, B. Linju Yen, Chen‐Yi Weng, Ju‐Hsin Hsu, Ming‐Hsien Tsai, Salim Arrokhman, Pinpin Lin   +7 more
wiley   +1 more source

Three-Dimensional Trilineage Differentiation Conditions for Human Induced Pluripotent Stem Cells

Bioengineering
Human induced pluripotent stem cells (hiPSCs) hold great potential for regenerative medicine. However, optimizing their differentiation into specific lineages within three-dimensional (3D) scaffold-based culture systems that mimic in vivo environments ...
Md Sharifur Rahman, Guangyan Qi, Quan Li, Xuming Liu, Jianfa Bai, Mingshun Chen, Anthony Atala, Xiuzhi Susan Sun   +7 more
doaj   +1 more source

Embryotoxic Effects of Monosodium Methyl Arsenate (MSMA) on Gallus gallus: Morphological and Morphometric Evidence of Developmental Disruptions

Environmental Toxicology, EarlyView.
ABSTRACT Anthropogenic activities and the large volume of compounds released into the environment are sources of contamination for plants, animals, and humans. The herbicide monosodium methyl arsenate (MSMA) ranks among the best‐selling agricultural pesticides in Brazil.
Daniel Moreira Melo, Eduarda Scalfoni Tavares, Melyssa Kmecick, Juliana Castro Monteiro Pirovani   +3 more
wiley   +1 more source

BRD9 inhibition as potential treatment option for testicular germ cell tumors

Andrology, EarlyView.
Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen, Christine Sanders, Florian Fronhoffs, Kai Funke, Glen Kristiansen, Hubert Schorle   +5 more
wiley   +1 more source

Mechanisms of early Drosophila mesoderm formation

, 1992
Several morphogenetic processes occur simultaneously during Drosophila gastrulation, including ventral furrow invagination to form the mesoderm, anterior and posterior midgut invagination to create the endoderm, and germ band extension.
Casal, J. ; https://orcid.org/, Grunewald, B. ; https://orcid.org/, Reuter, R., Leptin, M. ; https://orcid.org/   +3 more
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