Results 251 to 260 of about 99,345 (353)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Rewiring gene circuits to dissect oscillatory signaling dynamics. [PDF]

Genes Dev
van Oostrom MJ, Sonnen KF.
europepmc   +1 more source

Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites.

, 1994
E E Quertermous, Hiroko Hidai, Michael A. Blanar, Thomas Quertermous   +3 more
openalex   +2 more sources

Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley   +1 more source

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti‐Tumor Activity Against Ewing Sarcoma

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz, Thais Helena Maciel Fernandes, Marcela Silva Lopes, Lewis Elson, Andreas Krämer, Lucas Rodrigo de Souza, Isadora Serraglio Fortes, Geórgia Silva Pinto, Martha Cestari Silva Martins, Henrique Barros de Lima, André da Silva Santiago, Lauro José Gregianin, Katlin Brauer Massirer, Mário Henrique Bengtson, Rafael Roesler, Stefan Knapp, Stefan A. Laufer, Saulo Fernandes de Andrade   +17 more
wiley   +1 more source

dock11 Knockdown in Zebrafish Disrupts Embryogenesis: Insights Into the Genetic Causes of Early Pregnancy Loss. [PDF]

J Cell Mol Med
Liu C, Wang M, Chen F, Chen M, Yao Y, Huang W.   +5 more
europepmc   +1 more source

A Rare Case of Spontaneous Rupture of Giant Sacrococcygeal Teratoma: A Case Report From Muhimbili National Hospital, Tanzania

Clinical Case Reports, Volume 14, Issue 1, January 2026.
T1 and T2 weighed images of abdominopelvic MRI showing a sacrococcygeal teratoma Altman type II. ABSTRACT A rare but potentially fatal neonatal emergency, ruptured sacrococcygeal teratoma (SCT) is characterized by abrupt distension of the abdomen, anemia, and shock from hemorrhage into the tumor or peritoneal cavity.
Rajabu Athumani Bakari, Alfred Chibwae, Zubeir Omar Zubeir, Nanyokye Nasira Kidoko, Georvin Marko Haule, Mwajabu Rashidi Mbaga, Alex Mashaka, Victor T. Ngotta, Zaitun M. Bokhary   +8 more
wiley   +1 more source

mTORC2-mediated cell-cell interactions promote BMP4-induced WNT activation and mesoderm differentiation. [PDF]

Stem Cell Reports
Tong L, Batool F, Chiu YH, Wu PD, Zhou Y, Ma X, Atanur S, Cui W.   +7 more
europepmc   +1 more source

Factors Required for Differentiation of Chick Precardiac Mesoderm Cultured in vitro.

, 1991
Yoshihito Yamazaki, Reiji Hirakow
openalex   +2 more sources

Mature Cystic Teratoma of the Right Adrenal Gland in a Pediatric Patient: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Adrenal teratomas are rare neoplasms, most often benign but with potential for malignant transformation, particularly in the pediatric population. A seven‐year‐old girl from kawasoti, Nepal, presented with intermittent right‐sided abdominal pain for 2 months, initially attributed to dietary factors such as junk food intake.
Amit Gautam, Pukar Adhikari, Shishir Bhandari, Jabir Ahamad Miya, Nikesh Tiwari   +4 more
wiley   +1 more source