Results 191 to 200 of about 27,540 (239)
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Neurochemical studies on the mesolimbic circuitry of antinociception
Brain Research, 1991Previous studies using the technique of microinjection into brain nuclei indicated that the periaqueductal gray (PAG), nucleus accumbens, habenula and amygdala play an essential role in pain modulation and that these nuclei possibly act through a 'mesolimbic neural loop' to exert an analgesic effect, in which Met-enkephalin (MEK) and beta-endorphin ...
Q P, Ma, J S, Han
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Functional significance of mesolimbic dopamine
Neuroscience & Biobehavioral Reviews, 1995Although a large body of neuropharmacological evidence suggests that the mesolimbic dopamine system (ML DA) is critical for goal-directed behaviors, exactly which aspects of behavior are mediated or modulated by this system remains a matter of conjecture.
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Mesolimbic dopamine in obesity and diabetes
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2007monoaminergic neurotransmitter dopamine plays a critical role in various vital functions, including hormonal regulation, reward, emotions, and food intake. Multiple aspects of food intake that include food selection, satiety, and energy expenditure could be modulated by changes in ...
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Limbic/mesolimbic connections and the pathogenesis of schizophrenia
Biological Psychiatry, 1991The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia.
J G, Csernansky +2 more
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Insulin actions in the mesolimbic dopamine system
Experimental Neurology, 2019As a major circulating feeding related hormone, insulin crosses the brain blood barrier and acts on the central nervous system to modulate both homeostatic and non-homeostatic feeding behaviours. The mesolimbic dopamine system is implicated in motivation and the reinforcement of food intake, and it can be delicately tuned in response to insulin ...
Shuai, Liu, Stephanie L, Borgland
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CART peptide and the mesolimbic dopamine system
Peptides, 2006Over the past decade, CART peptide has been commonly associated with the rewarding and reinforcing properties of drugs of abuse and natural rewards such as food. The mesolimbic dopamine system is the predominant pathway involved in mediating reward and reinforcement.
Yoland Smith
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Mesolimbic dopaminergic neurones and somatodendritic mechanisms
Neuroscience Letters, 1979The concept that a neurone may release transmitter from both dendritic and axonal sites was investigated by studying mesolimbic dopaminergic neurones. The rat ventral tegmentum (containing dendrites and somata of mesolimbic dopaminergic neurones) possessed high levels of dopamine and tyrosine hydroxylase.
P M, Beart, D, McDonald, A L, Gundlach
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The Functional Output of the Mesolimbic Dopamine System
Annals of the New York Academy of Sciences, 1988In summary, the nucleus accumbens, located at the interface of the limbic projections from the amygdala, hippocampus, and cingulate cortex, and receiving extrapyramidal fibers from midbrain DA-containing nuclei, is well situated to form neural circuitry that mediates the behaviorally activating properties of several stimulants.
G F, Koob, N R, Swerdlow
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Opiate receptors on mesolimbic dopaminergic neurons
Neuroscience Letters, 1978Abstract Following electrocoagulation of dopaminergic cell bodies of the mesolimbic system, [ 3 H]naloxone binding decreases significantly in septum and nucleus accumbens. The latter effect is also observed after local injection of 6-hydroxydopamine.
H, Pollard +4 more
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The Mesolimbic Dopamine Reward Circuit in Depression
Biological Psychiatry, 2006The neural circuitry that mediates mood under normal and abnormal conditions remains incompletely understood. Most attention in the field has focused on hippocampal and frontal cortical regions for their role in depression and antidepressant action. While these regions no doubt play important roles in these phenomena, there is compelling evidence that ...
Eric J, Nestler, William A, Carlezon
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