Results 61 to 70 of about 27,540 (239)
Dopamine Dysregulation in Reward and Autism Spectrum Disorder
Brain SciencesAutism spectrum disorder (ASD) is primarily characterized by core deficits in social skills, communication, and cognition and by repetitive stereotyped behaviors.
Kenneth Blum +9 more
doaj +1 more source
Spinal pathways involved in somatosensory inhibition of the psychomotor actions of cocaine
Scientific Reports, 2017 Previous studies have demonstrated that somatosensory stimuli influence dopamine transmission in the mesolimbic reward system and can reduce drug-induced motor behaviors, craving and dependence.
Suchan Chang +11 more
doaj +1 more source
Dopamine Axon Targeting in the Nucleus Accumbens in Adolescence Requires Netrin-1
Frontiers in Cell and Developmental Biology, 2020 The fine arrangement of neuronal connectivity during development involves the coordinated action of guidance cues and their receptors. In adolescence, the dopamine circuitry is still developing, with mesolimbic dopamine axons undergoing target ...
Santiago Cuesta +11 more
doaj +1 more source
Apathy in Lewy Body Disorders: A Position Paper
Movement Disorders, EarlyView.Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky +12 more
wiley +1 more source
Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways
Scientific Reports, 2021 Our ability to develop the cognitive strategies required to deal with daily-life stress is regulated by region-specific neuronal networks. Experimental evidence suggests that prolonged stress in mice induces depressive-like behaviors via morphological ...
F. Quessy +4 more
doaj +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu +15 more
wiley +1 more source
How the Sea Salt Chocolate Cookie Became a Thing: The Role of Flavor Pairing in Obesity
Obesity, EarlyView.Proposed framework illustrating how flavor pairing and multisensory flavor architecture may sustain hedonic eating through enhanced palatability, reward preservation, delayed sensory‐specific satiety, and post‐ingestive signaling, thereby promoting excess energy intake and obesity risk.
Mohammed Ayyad, Eugene Kim
wiley +1 more source
The neuroscience of positive memory deficits in depression
Frontiers in Psychology, 2015 Adults with unipolar depression typically show poor episodic memory for positive material, but the neuroscientific mechanisms responsible for this deficit have not been characterized.
Daniel Gerard Dillon
doaj +1 more source
Valuation of knowledge and ignorance in mesolimbic reward circuitry [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Humans desire to know what the future holds. Yet, at times they decide to remain ignorant (e.g., reject medical screenings). These decisions have important societal implications in domains ranging from health to finance.
Charpentier, Caroline J. +2 more
openaire +6 more sources
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective An increasing number of women of childbearing age worldwide are using glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and are advised to use effective contraception during treatment. Nevertheless, maternity services are encountering increasing numbers of women exposed to GLP‐1 RAs shortly before conception or during pregnancy ...
Katherine G. Y. Lau +6 more
wiley +1 more source