Results 71 to 80 of about 27,540 (239)

Dopamine signaling in food addiction: role of dopamine D2 receptors [PDF]

BMB Reports, 2013
Dopamine (DA) regulates emotional and motivationalbehavior through the mesolimbic dopaminergic pathway.Changes in DA signaling in mesolimbic neurotransmission arewidely believed to modify reward-related behaviors and aretherefore closely associated with ...
Ja-Hyun Baik
doaj   +1 more source

How common is alcohol use disorder in posttraumatic stress disorder? A systematic review, meta‐analysis, and moderator analysis

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Comorbidity between posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) complicates care, yet reported prevalence varies widely across settings and methods. We estimated AUD prevalence among adults with PTSD and identified sources of variability.
Maria Olivia Pozzolo Pedro, Manoela Pozzolo Pedro, Gabriella Zimmer Monteiro, Valquíria Custodio Klaumann, Priscila Dib Gonçalves, Silvia S. Martins, João Maurício Castaldelli‐Maia   +6 more
wiley   +1 more source

Functional integrity of mesolimbic-hippocampal circuits is associated with anhedonia in individuals with early life stress

Anhedonia reflects a transdiagnostic deficit in a range of processes that impact reward and motivation. While human neuroimaging has mainly focused on striatal-related alterations in anhedonia, animal models suggest hippocampal [HPC] novelty processing ...
Jason Schiffman, Vijay A Mittal, Blake L Elliott, Ian O’Shea, Lauren M Ellman, Kathleen J O’Brien, Vishnu P Murty   +6 more
core   +1 more source

Proof‐of‐concept trial of PP‐01 for mitigating cannabis withdrawal syndrome in participants with cannabis use disorder

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Cannabis withdrawal symptoms can be severe and protracted, significantly impeding the ability to abstain from cannabis use, resulting in failed quit attempts and relapse. This clinical trial evaluated safety and efficacy of PP‐01, a novel dual‑mechanism of action, investigational agent, for mitigating cannabis ...
Ashley F. Slagle, Jay Constantine, Harvey Kushner, Shelli Graham, Ginger Constantine   +4 more
wiley   +1 more source

Mesolimbic dopamine pathway

Mezolimbički put dopamina jedan je od četiri najvažnija puta dopamina u mozgu. Povezuje ventralno tegmentalno područje, gdje dopamin prvotno nastaje, i nucleus accumbens u striatumu.
Bajšanski, Vedran
core   +2 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Mesolimbic lipid sensing and the regulation of feeding behaviour [PDF]

, 2015
In both developed and emerging countries, sedentary life style and over exposition to high energy dense foods has led to a thermodynamic imbalance and consequently obesity.
Luquet Serge, Celine Cansell, Serge Luquet, Cansell, Céline, Cansell Celine, Luquet, Serge   +5 more
core   +1 more source

Endocannabinoids Interact With the Dopaminergic System to Increase Sexual Motivation: Lessons From the Sexual Satiety Phenomenon

Frontiers in Behavioral Neuroscience, 2019
In male rats, copulation to satiety induces a long-lasting sexual inhibitory state, considered to rely on a decreased sexual motivation. Dopaminergic transmission at the mesolimbic system plays a central role in the regulation of male sexual motivation ...
Ana Canseco-Alba, Gabriela Rodríguez-Manzo   +1 more
doaj   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Sex Differences and the Role of Estradiol in Mesolimbic Reward Circuits and Vulnerability to Cocaine and Opiate Addiction

Frontiers in Behavioral Neuroscience, 2020
Although both men and women become addicted to drugs of abuse, women transition to addiction faster, experience greater difficulties remaining abstinent, and relapse more often than men.
Saurabh S. Kokane, Linda I. Perrotti
doaj   +1 more source