Results 91 to 100 of about 27,540 (239)

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice

, 2018
Ghrelin has been attributed various physiological processes including food intake and reward regulation, through activation of the mesolimbic dopamine system.
Winsa Jörnulf, Julia,, Aimilia Lydia Kalafateli, Heilig, Markus, Markus Heilig, Elisabet Jerlhag, Heilig, Markus,, Vallöf, Daniel,, Jornulf, Julia Winsa,, Daniel Vallöf, Jerlhag, Elisabet,, Julia Winsa Jörnulf, Kalafateli, Aimilia Lydia,, Jerlhag, Elisabeth,   +12 more
core   +1 more source

Influence of GLP‐1‐Based Pharmacotherapies on Eating Behavior, Appetite, and Energy Intake in Adults With Overweight or Obesity: A Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Introduction Although GLP‐1‐based pharmacotherapies achieve clinically significant weight loss, their influence on eating behavior is unknown. Methods This systematic review examined the effects of GLP‐1‐based pharmacotherapies on eating behavior, appetite, and energy intake in adults (≥ 18 years) with overweight or obesity (BMI ≥ 25 kg/m2 ...
Clarissa Dakin, Jordan D. Beaumont, Beverley O′Hara   +2 more
wiley   +1 more source

Central insulin modulates food valuation via mesolimbic pathways

, 2017
Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways ...
Katrin Giesen, Sebastian M. Schmid, Stefanie Brassen, Lena J. Tiedemann, Paul Francke, Judith Hettel, Christian Büchel   +6 more
core   +1 more source

Editorial: Community Series: Avian Models for Social Cohesion, Volume II

Frontiers in Physiology, 2023
Gergely Zachar, András Csillag
doaj   +1 more source

Antipsychotics‐Induced Hyposalivation Mediated by Impaired Salivary Ca2+ Signaling

Oral Diseases, EarlyView.
ABSTRACT Objectives Antipsychotic‐induced salivary dysfunction such as hyposalivation is a prevalent clinical challenge that severely compromises oral health and quality of life. Although typical and atypical antipsychotics have their therapeutic target in the central nervous system, their direct molecular mechanisms within the salivary glands remain ...
Chaelin Chung, Soohyun Kim, Yoo‐Bin Kim, Hee‐Kyung Park, Se‐Young Choi   +4 more
wiley   +1 more source

Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding

, 2009
SummaryThe lateral hypothalamic area (LHA) acts in concert with the ventral tegmental area (VTA) and other components of the mesolimbic dopamine (DA) system to control motivation, including the incentive to feed. The anorexigenic hormone leptin modulates
Gong, Yusong, Leinninger, Gina M., Faouzi, Miro A., Louis, Gwendolyn W., Myers, Martin G., Rhodes, Christopher J., Münzberg, Heike, Opland, Darren M., Jones, Justin C., Diano, Sabrina, Yang, Hongyan, Becker, Jill B., Wilson, Hilary, Horvath, Tamas L., Leshan, Rebecca L., Seeley, Randy J., Chua, Streamson, Jo, Young-Hwan, Barrera, Jason G.   +18 more
core   +1 more source

Mesolimbic structural covariance in ADHD

, 2020
Dysfunction in the mesolimbic dopamine system is a hallmark of attention-deficit/hyperactivity disorder (ADHD). The relationship between brain structure in this critical system and symptomatology, however, is not yet fully understood.
Eleanor Barbara George, Rachael Wright, Shabnam Hakimi, R. Alison Adcock   +3 more
core   +1 more source

Childhood adversity and suicidal ideation: The roles of personality functioning, psychological distress and anhedonia in a serial‐parallel mediation model

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Background Understanding the factors that predict suicidality is critical for identifying risks and guiding interventions. Various factors that predict suicide risk have been identified to date, and recent research has begun to focus on the dynamic mechanisms among these factors.
Ömer Taha Sözer
wiley   +1 more source

Mesolimbic expression of neurotensin and neurotensin receptor during stress-induced gastric mucosal injury

, 1998
Neurotensin is a neurotransmitter present in the brain and gastrointestinal tract. Intracerebroventricular injection of neurotensin protects rats from gastric mucosal injury caused by cold water restraint (CWR).
Gordon L. Kauffman, Anne M. Karinch, Lianping Xing   +2 more
core   +1 more source