Results 11 to 20 of about 1,026 (145)
Determining the Impact of Combination Oral Contraceptives on Von Willebrand Factor and Factor VIII in Healthy Patients and Patients With Von Willebrand Disease: A Scoping Review and Meta-Analysis. [PDF]
HaemophiliaABSTRACT Introduction Von Willebrand disease (VWD) is a bleeding disorder characterized by a deficiency or dysfunction of Von Willebrand factor (VWF) and/or Factor VIII (FVIII), critical coagulation proteins. Individuals with VWD often use combination oral contraceptives (COCs) to manage heavy menstrual bleeding.
Justason E +4 more
europepmc +2 more sources
Angewandte Chemie, Volume 135, Issue 44, October 26, 2023., 2023 A practical photoredox/iron dual catalytic system has been developed for efficient synthesis of 1,2‐aryl(alkenyl) heteroatomic cores with high site selectivity. The excellent functional group compatibility, scalability, use of readily available starting materials, and application to late‐stage functionalization underscore the potential protocol's ...
Weigang Zhang +7 more
wiley +2 more sources
Strategies for the Controlled Hydrostannylation of Alkynes
European Journal of Organic Chemistry, Volume 26, Issue 42, November 7, 2023., 2023 This Concept article summarises recent advances in approaches to the synthesis of important vinyl stannane building blocks in a stereocontrolled and regiocontrolled manner. Particular emphasis is put on those routes in which judicious choice of ligand affords a switchable reaction, providing routes to stereodefined olefins from a single starting ...
Dean D. Roberts, Mark G. McLaughlin
wiley +1 more source
The Association Between Estrogen-Containing Oral Contraceptive Pills and Hypothyroidism. [PDF]
Int J EndocrinolBackground: Hypothyroidism is an endocrine disorder that affects 10 times more females than males, with substantial health impacts. The role of estrogen‐containing oral contraceptives (OCPs) in influencing thyroid function remains relatively underexplored. This study investigated the association between estrogen‐containing OCP use and hypothyroidism in
Alkahlout L +5 more
europepmc +2 more sources
CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride
Clinical and Translational Science, Volume 15, Issue 11, Page 2613-2624, November 2022., 2022 Abstract Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease. In this study, we aimed to explore the impact of relevant variants in CYP3A4 and CYP2C8 and other pharmacogenes, along with demographic characteristics, on cinitapride ...
Diana María Campodónico +12 more
wiley +1 more source
Norethisterone‐induced cholestasis: A case report
Clinical Case Reports, Volume 10, Issue 3, March 2022., 2022 The estrogenic component of combined oral contraceptive pill is the one generally believed to be responsible for drug‐induced cholestasis. Progesteron‐only induced‐cholestasis is quite rare and could be triggered by underlying predispositions. Abstract Case presentation This case report concerns a 49‐year‐old woman who developed cholestasis (build‐up ...
Safa Moussaoui +11 more
wiley +1 more source
Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 3, March 2022., 2022 Abstract Background The evaluation of activated protein C (APC) resistance based on the endogenous thrombin potential (ETP) is recommended during the development of steroid contraceptives in women. In 2019, this assay was validated on the calibrated automated thrombogram (CAT) device.
Laure Morimont +7 more
wiley +1 more source
Virtual and in Vitro Screening Employing a Repurposing Approach Reveal 13-cis-Retinoic Acid is a PTP1B Inhibitor. [PDF]
ChemMedChemA computational screening using cheminformatics and molecular docking has been performed on PTP1B. In vitro assays have revealed that 13‐cis‐retinoic acid is a competitive inhibitor. This is the first report of 13‐cis‐retinoic acid as PTP1B inhibitor, making it a valuable candidate for future research toward its repositioning.
Del Carmen Navarrete-Mondragón R +4 more
europepmc +2 more sources
Use of contraceptives and risk of inflammatory bowel disease: a nested case–control study
Alimentary Pharmacology &Therapeutics, Volume 55, Issue 3, Page 318-326, February 2022., 2022 Nested case‐control study including 4932 IBD cases matched to 29 340 controls. Use of oestrogen‐containing contraception was associated with development of both CD and UC. Progestogen‐only pills were not associated with CD but there was a modest association with UC. Parenteral progestogen‐only methods were not associated with IBD.
Thomas Joshua Pasvol +4 more
wiley +1 more source
Reproductive Medicine and Biology, Volume 21, Issue 1, January/December 2022., 2022 Abstract Purpose To retrospectively evaluate the effectiveness of PGT‐SR by array comparative genomic hybridization (aCGH) or next‐generation sequencing (NGS) in preventing recurrent miscarriages. Methods Thirty one couples with balanced translocation who underwent 68 PGT‐SR cycles between 2012 and 2020 were evaluated.
Tatsuya Nakano +5 more
wiley +1 more source