Results 31 to 40 of about 3,947 (253)

CYP2C8*3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride

Clinical and Translational Science, Volume 15, Issue 11, Page 2613-2624, November 2022., 2022
Abstract Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease. In this study, we aimed to explore the impact of relevant variants in CYP3A4 and CYP2C8 and other pharmacogenes, along with demographic characteristics, on cinitapride ...
Diana María Campodónico, Pablo Zubiaur, Paula Soria‐Chacartegui, Ana Casajús, Gonzalo Villapalos‐García, Marcos Navares‐Gómez, Antía Gómez‐Fernández, Raúl Parra‐Garcés, Gina Mejía‐Abril, Manuel Román, Samuel Martín‐Vílchez, Dolores Ochoa, Francisco Abad‐Santos   +12 more
wiley   +1 more source

Monitoring Drug Safety Information - Recommendations of Foreign Regulatory Authorities

Безопасность и риск фармакотерапии, 2020
Analysis of administrative decisions of foreign regulatory authorities on the recoil of medicines and/or the need for changes in the instructions for their medical use due to changes in the safety profi le, conducted by experts of the Scientifi c Centre ...
Elena V. Shubnikova, Marya A. Darmostukova, Irina I. Snegireva, Evgeniya O. Zhuravleva   +3 more
doaj   +1 more source

Norethisterone‐induced cholestasis: A case report

Clinical Case Reports, Volume 10, Issue 3, March 2022., 2022
The estrogenic component of combined oral contraceptive pill is the one generally believed to be responsible for drug‐induced cholestasis. Progesteron‐only induced‐cholestasis is quite rare and could be triggered by underlying predispositions. Abstract Case presentation This case report concerns a 49‐year‐old woman who developed cholestasis (build‐up ...
Safa Moussaoui, Mehdi Abdelwahed, Nabil Ben Chaaben, Ahlem Bellalah, Najah Ben Fadhel, Arwa Guediche, Mejda Zakhama, Ramzi Tababi, Karim Aouam, Zakhama Abdelfattah, Hichem Loghmari, Leila Safer   +11 more
wiley   +1 more source

Analytical performance of the endogenous thrombin potential–based activated protein C resistance assay on the automated ST Genesia system

Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 3, March 2022., 2022
Abstract Background The evaluation of activated protein C (APC) resistance based on the endogenous thrombin potential (ETP) is recommended during the development of steroid contraceptives in women. In 2019, this assay was validated on the calibrated automated thrombogram (CAT) device.
Laure Morimont, Charline Leclercq, Marie Didembourg, Émilie De Gottal, Audrey Carlo, Ulysse Gaspard, Jean‐Michel Dogné, Jonathan Douxfils   +7 more
wiley   +1 more source

Virtual and in Vitro Screening Employing a Repurposing Approach Reveal 13-cis-Retinoic Acid is a PTP1B Inhibitor. [PDF]

ChemMedChem
A computational screening using cheminformatics and molecular docking has been performed on PTP1B. In vitro assays have revealed that 13‐cis‐retinoic acid is a competitive inhibitor. This is the first report of 13‐cis‐retinoic acid as PTP1B inhibitor, making it a valuable candidate for future research toward its repositioning.
Del Carmen Navarrete-Mondragón R, Cortés-Benítez F, Elena Mendieta-Wejebe J, González-Andrade M, Pérez-Villanueva J.   +4 more
europepmc   +2 more sources

Use of contraceptives and risk of inflammatory bowel disease: a nested case–control study

Alimentary Pharmacology &Therapeutics, Volume 55, Issue 3, Page 318-326, February 2022., 2022
Nested case‐control study including 4932 IBD cases matched to 29 340 controls. Use of oestrogen‐containing contraception was associated with development of both CD and UC. Progestogen‐only pills were not associated with CD but there was a modest association with UC. Parenteral progestogen‐only methods were not associated with IBD.
Thomas Joshua Pasvol, Stuart Bloom, Anthony Walter Segal, Greta Rait, Laura Horsfall   +4 more
wiley   +1 more source

Analysis of clinical outcomes and meiotic segregation modes following preimplantation genetic testing for structural rearrangements using aCGH/NGS in couples with balanced chromosome rearrangement

Reproductive Medicine and Biology, Volume 21, Issue 1, January/December 2022., 2022
Abstract Purpose To retrospectively evaluate the effectiveness of PGT‐SR by array comparative genomic hybridization (aCGH) or next‐generation sequencing (NGS) in preventing recurrent miscarriages. Methods Thirty one couples with balanced translocation who underwent 68 PGT‐SR cycles between 2012 and 2020 were evaluated.
Tatsuya Nakano, Michiko Ammae, Manabu Satoh, Satoshi Mizuno, Yoshiharu Nakaoka, Yoshiharu Morimoto   +5 more
wiley   +1 more source

Prevalence and Risk Factors of Vulvovaginal Candidosis during Pregnancy: A Review

Infectious Diseases in Obstetrics and Gynecology, Volume 2022, Issue 1, 2022., 2022
Vulvovaginal candidosis (VVC) is a symptomatic vaginal yeast infection, especially caused by Candida spp. Although VVC is common among reproductive‐age women, prevalence studies notice the uprise of vaginal Candida colonization to 30% during pregnancy by culture, especially in the last trimester.
Tasfia Disha, Fahim Haque, Atif Amin Baig   +2 more
wiley   +1 more source

The cooccurrence of heightened media attention and adverse drug reaction reports for hormonal contraception in the United Kingdom between 2014 and 2017

British Journal of Clinical Pharmacology, Volume 87, Issue 4, Page 1768-1777, April 2021., 2021
Aim The aim of this study was to examine the cooccurrence of heightened media attention after the publication of a paper by Skovlund et al in September 2016 on the link between hormonal contraception and depression or mood on adverse drug reaction (ADR) reports in the UK.
Lobke Geesje Maria Postma, Parastou Donyai   +1 more
wiley   +1 more source

Uso clínico de un nuevo progestógeno oral: Chlormadinone

Revista Colombiana de Obstetricia y Ginecología, 1963
Este estudio comprende ei uso de un estrógeno sintético, Etinil estradiol 3- metil éter (Mestranol) y una progesterona sintética la 6 Cloro-6 dihidro 17- Alfa acetoxi-progesterona (Chlormadinone) administrados a cincuenta y siete pacientes, veintisiete ...
Fernando del Corral, Antonio Artuz, Carlos A. Salcedo, José Vicente Erazo, Gilberto Angel   +4 more
doaj   +1 more source