Results 111 to 120 of about 407,464 (291)
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Metastatic primary lung tumor in three dogs
Tumor primário pulmonar metastático em três cães
Semina: Ciências Agrárias, 2012 Primary lung tumors (PLT) are uncommon in dogs and occasionally metastasize to distant organs. This report describes three cases of PLT in dogs with epithelial origin, diagnosed post mortem through histopathology and immunohistochemistry.
Antônio Carlos Faria dos Reis +4 more
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Impacto da ultra-sonografia intra-operatória nas cirurgias para ressecção de metástases hepáticas
, 2005 Marcela Pécora Cohen +2 more
openalex +1 more source
Metástases pulmonares atípicas: apresentações tomográficas [PDF]
, 2002 Larissa Bodanese +3 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Metástases Vertebrais: Breve Revisão do Estado da Arte
Gazeta Médica, 2017 O tratamento das metástases vertebrais sofreu uma evolução relevante nos últimos anos, com o desenvolvimento tecnológico da radioterapia/radiocirurgia estereotáxica, novas combinações de quimioterapia e imunoterapia, assentes numa nova subclassificação ...
Bruno Santiago +2 more
doaj +2 more sources